About: Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů

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About: Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů Goto Sponge NotDistinct Permalink

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rdf:type	http://linked.opendata.cz/ontology/domain/vavai/Zamer
Description	At the molecular and cellular level we will study the basic life processes maintaining the structural and functional integrity of living organisms. The project should elucidate the complex mechanisms of regulation of gene expression, of the role of products of these genes in the regulation of cell functions in normal as well as pathologic cells, in gametogenesis and development of the organism, in the regulation of immune processes in infectious, tumour or autoimmune diseases. Knowledge of the structure of selected genes and mechanisms of their regulation and function in microorganisms, cellular or animal models is a theoretical prerequisite for future approaches to diagnostics of pathologic condition and for targeted therapy. These approaches can also be validated in biotechnological applications. The proposed research will be based on the most recent molecular biologic, cytologic and genomic methodical approaches, preparation and use of targeted genetically modified organisms. (en) Na molekulární a buněčné úrovni budou studovány základní životní procesy a patologické procesy narušující strukturní i funkční integritu živých organismů. Cílem výzkumného záměru je přispět zejména k objasnění komplexních mechanismů regulace exprese genů, úlohy produktů těchto genů v řízení základních buněčných funkcí u normální i patologicky změněné buňky, v gametogenezi a vývoji organismu, v regulaci imunitních dějů při infekčních, nádorových nebo autoimunitních chorobách. Poznání struktury vybraných genů a obecných zákonitostí týkajících se jejich regulace a funkce u mikroorganismů, buněčných nebo zvířecích modelů je nezbytným teoretickým předpokladem pro vypracování postupů jak pro budoucí diagnostiku patologických stavů, tak i pro případné cílené terapeutické zásahy. Navrhovaný výzkum bude založen na nejmodernějších molekulárně biologických, cytologických a genomických metodických přístupech, bioinformatické analýze dat, přípravě a využití cíleně geneticky modifikovaných organismů.
Title	Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů Molecular Genetics and Cellular Bases of Key Biological Processes: Gene Expression, Oncogenesis, Virus Replication, Immunity and Development of the Organism (en)
http://linked.open...kovaStatniPodpora	http://linked.opendata.cz/resource/domain/vavai/zamer/AV0Z50520514/celkovaStatniPodpora
http://linked.open...ez/celkoveNaklady	http://linked.opendata.cz/resource/domain/vavai/zamer/AV0Z50520514/celkoveNaklady
http://linked.open...datumDodatniDoRIV	2012-07-03 (xsd:date)
http://linked.open...vavai/cez/dodavka	http://linked.opendata.cz/resource/domain/vavai/dodavka/CEZ12-AV0-U%2F01%3A1
http://linked.open...ez/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...in/vavai/cez/faze	33136474
http://linked.open...ai/cez/hlavniObor	EB - Genetika a molekulární biologie
http://linked.open...vai/cez/hodnoceni	V - Vynikající výsledky (s mezinárodním významem apod.). Zároveň byly splněny cíle a předpokládané výsledky uvedené ve smlouvě / rozhodnutí o poskytnutí podpory.
http://linked.open.../cez/kategorieVaV	ZV - Základní výzkum
http://linked.open.../cez/klicovaSlova	functional genomics; bioinformatics; genome mapping; cell and developmental and structural biology; immunology; retrovirology; fertilization; biotechnolgy; oncogenes; differentiation; tumors; receptors; cytokines; signal tranduction; cytoskeleton (en)
http://linked.open...cez/partnerHlavni	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...z/poceVysledkuRIV	847 (xsd:int)
http://linked.open...inujicichPrijemcu	0 (xsd:int)
http://linked.open...cez/pocetPrijemcu	1 (xsd:int)
http://linked.open...ocetSpoluPrijemcu	0 (xsd:int)
http://linked.open...enychVysledkuVRIV	847 (xsd:int)
http://linked.open...lneniVMinulemRoce	2011-12-06 (xsd:date)
http://linked.open.../prideleniPodpory	http://linked.opendata.cz/resource/domain/vavai/cez/prideleniPodpory/AV0Z50520514
http://linked.open.../vavai/cez/resort	Academy of Sciences of the Czech Republic
http://linked.open...iciPoslednihoRoku	2011
http://linked.open...atUdajeProjZameru	2012
http://linked.open...usZobrazovaneFaze	DUU
http://linked.open...ez/ukonceniReseni	2011-12-31 (xsd:date)
http://linked.open.../cez/vedlejsiObor	EC - Imunologie FD - Onkologie a hematologie
http://linked.open...ez/zahajeniReseni	2005-01-01 (xsd:date)
http://linked.open...n/vavai/cez/zamer	Z - Výzkumný záměr financovaný ze státního rozpočtu
http://linked.open...sledkuDodavatelem	Bylo získáno množství nových poznatků o molekulárních a buněčných mechanismech základních životních procesů (regulace exprese genů, řízení základních buněčných funkcí u normální i patologicky změněné buňky, vývoj organismu, regulace imunitních dějů). Výsledky byly publikovány v kvalitních mezinárodních časopisech a některé z nich prakticky využity ve spolupráci s biotechnologickými firmami. (cs) Many new results were obtained on molecular and cellular mechanisms of basic processes in cells and organisms (regulation of gene expression, basic functions of normal and pathologically changed cells, organism development, regulation of immune response). The results were published in quality international journals and some of them employed in collaboration with biotechnological companies. (en)
http://linked.open...cez/zivotniCyklus	ZBBBBBKU
is http://linked.open...n/vavai/riv/zamer of	Interallelic and intergenic incompatibilities of the Prdm9 (Hst1) gene in mouse hybrid sterility XIIth Symposium of Czech Reproductive Immunologists with International Participation, 2006 The effect of flavonoid derivatives on doxorubicin transport and metabolism Mouse to human comparative genetics reveals a novel immunoglobulin E-controlling locus on Hsa8q12 Leishmania parasite detection and quantification using PCR-ELISA Transcriptional provirus silencing as a crosstalk of de novo DNA methylation and epigenomic features at the integration site Transgenic mouse model expressing tdTomato under involucrin promoter as a tool for analysis of epidermal differentiation and wound healing The transmembrane region is responsible for targeting of adaptor protein LAX into %22heavy rafts'' Tubulins as therapeutic targets in cancer: from bench to bedside Ubiquitin-activating enzyme UBA1 is required for cellular response to DNA damage Transgenic RNAi in mouse oocytes: The first decade Transmembrane adaptor proteins in the high-affinity IgE receptor signaling γ-Tubulin 2 nucleates microtubules and is downregulated in mouse early embryogenesis Avidin-conjugated polymers with monobiotinylated antibody fragments: a new strategy for the noncovalent attachment of recombinant proteins for polymer therapeutics Crystallization of the Effector-Binding Domain of Repressor DeoR from Bacillus subtilis Mechanistic basis of infertility of mouse intersubspecific hybrids Lipophosphonoxins, method of their preparation and use Mouse nuclear myosin I knock-out shows interchangeability and redundancy of myosin isoforms in the cell nucleus Potent inhibition of drug-resistant HIV protease variants by monoclonal antibodies Enzymatic and structural analysis of the I47A mutation contributing to the reduced susceptibility to HIV protease inhibitor lopinavir Interpretation of protein/ligand crystal structure using QM/MM calculations: Case of HIV-1 protease/metallacarborane complex Kit- and FceRI-induced differential phosphorylation of the transmembrane adaptor molecule NTAL/LAB/LAT2 allows flexibility in its scaffolding function in mast cells Intracellular expression profiles measured by real-time PCR tomography in the Xenopus laevis oocyte p38 MAPK plays an essential role in apoptosis induced by photoactivation of a novel ethylene glycol porphyrin derivative Chapter 11: RNA silencing in mammalian oocytes and early embryos Twists and turns in life and science. Foundation Series in Cancer Research Formation and temperature stability of G-quadruplex structures studied by electronic and vibrational dichroism spectroscopy combined with ab initio calculations Development of unique house mouse resources suitable for evolutionary studies of speciation Involvement of phosphatidylserine externalization in the down-regulation of c-myb expression in differentiating C2C12 cells Mouse consomic strains: Exploiting genetic divergence between Mus m. musculus and Mus m. domesticus subspecies Fine haplotype structure of a chromosome 17 region in the laboratory and wild mouse Engagement of phospholipid scramblase 1 in activated cells: implication for phosphatidylserine externalization and exocytosis IL-12 immunotherapy of minimal residual disease in murine models of HPV16-associated tumours: induction of immune responses, cytokine production and kinetics of immune cell subsets Induction of MHC class I molecule cell surface expression and epigenetic activation of antigen-processing machinery components in a murine model for human papilloma virus 16-associated tumours A single-amino-acid substitution in the TvbS1 receptor results in decreased susceptibility to infection by avian sarcoma and leukosis virus subgroups B and D and resistance to infection by subgroup E in vitro and in vivo Chicken C-type lectin-like receptor B-NK, expressed on NK and T cell subsets, binds to a ligand on activated splenocytes Wnt-expressing rat embryonic fibroblasts suppress Apo2L/TRAIL-induced apoptosis of human leukemia cells Glycopeptide dendrimers, Part III – a review: Use of glycopeptide dendrimers in immunotherapy and diagnosis of cancer and viral diseases LFA-1-mediated leukocyte adhesion regulated by interaction of CD43 with LFA-1 and CD147 Localization of porcine seminal plasma (PSP) proteins in the boar reproductive tract and spermatozoa Crystal structures of the effector-binding domain of repressor CggR from Bacillus subtilis reveal ligand-induced structural changes upon binding of several glycolytic intermediates Nucleotide sequence, organization and characterization of the (halo)aromatic acid catabolic plasmid pA81 from Achromobacter xylosoxidans A8 The identity of the transcription +1 position is crucial for changes in gene expression in response to amino acid starvation in Bacillus subtilis POTENTIAL APPLICATIONS OF TANDEM SHOCK WAVES IN CANCER TREATMENT Potential applications of tandem shock waves in cancer treatment MicroRNAs control de novo DNA methylation through regulation of transcriptional repressors in mouse embryonic stem cells Eye evolution: lens and cornea as an upgrade of animal visual system The role of Pax genes in eye evolution Cubozoan crystallins: evidence for convergent evolution of Pax regulatory sequences The core element of a CpG island protects avian sarcoma and leukosis virus-derived vectors from transcriptional silencing The surface-associated elongation factor Tu is concealed for antibody binding on viable pneumococci and meningococci Molecular characterization of full-length MLV-related endogenous retrovirus ChiRV1 from the chicken, Gallus gallus LCK dependent Fyn activation requires C-terminus dependent targeting of kinase active LCK to lipid rafts Surface expression of metabotropic glutamate receptor variants mGluR1a and mGluR1b in transfected HEK293 cells MMP19 is essential for T cell development and T cell-mediated cutaneous immune responses Cellular and humoral immune responses to chimeric EGFP-pseudocapsids derived from the mouse polyomavirus after their intranasal administration PPARG by dietary fat interaction influences bone mass in mice and humans Crystallization and preliminary X-ray diffraction analysis of mouse galectin-4 N-terminal carbohydrate recognition domain in complex with lactose Tetraalkylammonium derivatives as real-time PCR enhancers and stabilizers of the qPCR mixtures containing SYBR Green I Regulation of microtubule nucleation from membranes by complexes of membrane-bound gamma-tubulin with Fyn kinase and phosphoinositide 3-kinase Mapping the peptide and protein immune response in the larvae of the fleshfly Sarcophaga bullata Tyrosine phosphorylation of plant tubulin Class III beta-tubulin is constitutively coexpressed with glial fibrillary acidic protein and nestin in midgestational human fetal astrocytes: implications for phenotypic identity Porphyrin-bile acid conjugates: from saccharide recognition in the solution to the selective cancer cell fluorescence detection Optical sensing of sulfate by polymethinium salt receptors: colorimetric sensor for heparin

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