About: A single-amino-acid substitution in the TvbS1 receptor results in decreased susceptibility to infection by avian sarcoma and leukosis virus subgroups B and D and resistance to infection by subgroup E in vitro and in vivo

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About: A single-amino-acid substitution in the TvbS1 receptor results in decreased susceptibility to infection by avian sarcoma and leukosis virus subgroups B and D and resistance to infection by subgroup E in vitro and in vivo Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	ASLV family retroviruses contain 5 highly related envelope subgroups (A-E). Susceptibility or resistance of cells to infection by these ASLVs is given by 3 loci in chicken. The tvb gene encodes subgroup B, D, E ASLV receptors. Wild-type TvbS1 receptor confers susceptibility to subgroup B, D, E ASLVs. In this study the genetic defect underlying altered susceptibility of inbred chicken line M to infection by ASLV(B), (D), (E), C125S substitution in tvb-encoded TvbS1 receptor in this line, was identified. We show that this substitution significantly reduces susceptibility of line M cells to infection by ASLV(B) and (D) and virtually eliminates susceptibility to ASLV(E) infection in cultured cells and the incidence and growth of ASV-induced sarcomas in chickens. It also significantly reduces binding affinity of TvbS1 receptor for subgroup B, D, E ASLV envelope glycoproteins. These results are first demonstration of possible role of the Cys-rich domain 3 in the function of Tvb receptors. ASLV family retroviruses contain 5 highly related envelope subgroups (A-E). Susceptibility or resistance of cells to infection by these ASLVs is given by 3 loci in chicken. The tvb gene encodes subgroup B, D, E ASLV receptors. Wild-type TvbS1 receptor confers susceptibility to subgroup B, D, E ASLVs. In this study the genetic defect underlying altered susceptibility of inbred chicken line M to infection by ASLV(B), (D), (E), C125S substitution in tvb-encoded TvbS1 receptor in this line, was identified. We show that this substitution significantly reduces susceptibility of line M cells to infection by ASLV(B) and (D) and virtually eliminates susceptibility to ASLV(E) infection in cultured cells and the incidence and growth of ASV-induced sarcomas in chickens. It also significantly reduces binding affinity of TvbS1 receptor for subgroup B, D, E ASLV envelope glycoproteins. These results are first demonstration of possible role of the Cys-rich domain 3 in the function of Tvb receptors. (en) Ptačí sarkomové a leukosové viry (ASLV) tvoří pět interferenčních podskupin (A až E) a využívají pro vstup do buněk tří různých receptorů. Viry podskupin B, D a E vstupují do susceptibilních buněk přes receptor Tvb. Identifikovali jsme mutaci v receptoru Tvb, která podmiňuje semiresistentní fenotyp drůbeží inbrední linie M vůči virům podskupiny B a D a téměř úplnou resistenci ke skupině E. Mutace spočívá v záměně cysteinu v posici 125 v cysteinem bohaté doméně 3, která byla doposud pokládána za nedůležitou pro vazbu virových obalových glykoproteinů. Předpokládáme, že při absenci cytosinu 125 dochází k prodloužení receptorové molekuly a navázaný retrovirus je tak příliš daleko od membrány než aby mohl účinně fúsovat s cílovou buňkou. (cs)
Title	A single-amino-acid substitution in the TvbS1 receptor results in decreased susceptibility to infection by avian sarcoma and leukosis virus subgroups B and D and resistance to infection by subgroup E in vitro and in vivo A single-amino-acid substitution in the TvbS1 receptor results in decreased susceptibility to infection by avian sarcoma and leukosis virus subgroups B and D and resistance to infection by subgroup E in vitro and in vivo (en) Jednoaminokyselinová substituce v receptoru TvbS1 snižuje susceptibilitu k infekci ptačími sarkomovými a leukosovými viry podskupin B a D a podmiňuje resistenci k podskupině E in vitro a in vivo (cs)
skos:prefLabel	A single-amino-acid substitution in the TvbS1 receptor results in decreased susceptibility to infection by avian sarcoma and leukosis virus subgroups B and D and resistance to infection by subgroup E in vitro and in vivo A single-amino-acid substitution in the TvbS1 receptor results in decreased susceptibility to infection by avian sarcoma and leukosis virus subgroups B and D and resistance to infection by subgroup E in vitro and in vivo (en) Jednoaminokyselinová substituce v receptoru TvbS1 snižuje susceptibilitu k infekci ptačími sarkomovými a leukosovými viry podskupin B a D a podmiňuje resistenci k podskupině E in vitro a in vivo (cs)
skos:notation	RIV/68378050:_____/08:00306812!RIV09-AV0-68378050
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA523/07/1171), P(GA523/07/1282), Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Elleder, Daniel Hejnar, Jiří Plachý, Jiří Svoboda, Jan Reinišová, Markéta Geryk, Josef Šenigl, Filip
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	354521
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/08:00306812
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	retrovirus receptors; avian sarcoma and leukosis virus; resistance to retrovirus (en)
http://linked.open.../riv/klicoveSlovo	avian sarcoma and leukosis virus resistance to retrovirus retrovirus receptors
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[44990E6D2077]
http://linked.open...i/riv/nazevZdroje	Journal of Virology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	L1 retrotransposon-based transgenic chicken models Characterization of the cellular receptor Tvc and its role in the pathogenesis of avian leukosis viruses subgroup C-induced diseases
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	82
http://linked.open...iv/tvurceVysledku	Plachý, Jiří Svoboda, Jan Hejnar, Jiří Geryk, Josef Reinišová, Markéta Šenigl, Filip Elleder, Daniel Federspiel, M. J. Yin, X.
http://linked.open...ain/vavai/riv/wos	000253481000006
http://linked.open...n/vavai/riv/zamer	Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů
issn	0022-538X
number of pages	9 (xsd:int)
is http://linked.open...avai/riv/vysledek of	A single-amino-acid substitution in the TvbS1 receptor results in decreased susceptibility to infection by avian sarcoma and leukosis virus subgroups B and D and resistance to infection by subgroup E in vitro and in vivo A single-amino-acid substitution in the TvbS1 receptor results in decreased susceptibility to infection by avian sarcoma and leukosis virus subgroups B and D and resistance to infection by subgroup E in vitro and in vivo

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