| Attributes | Values |
|---|
| rdf:type
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| Description
| - U léčených myší byla detekována zvýšená produkce cytokinů, ale nebyl nalezen rozdíl v Th1/Th2 polarizaci imunitní odpovědi. Ve slezinách myší nesoucích TC-1 (MHC I+), ale ne TC-1/A9 (MHC I–) nádory, byly nalezeny cytotoxické CD8+ buňky. Ve slezinách léčených myší nesoucích TC-1/A9 nádory, byly naopak nalezena NK aktivita detekovatelná jako lýza NK senzitivních YAC-1 buněk. Snížený počet CD4+ a CD8+ buněk přetrvával I po léčbě; zatím co procento CD25+/CD4+ T regulačních buněk se neměnilo. Chemoterapie vedla ke zvýšení počtu imunosupresivních nezralých myeloidních buněk Gr-1+/CD11b+ (IMC) ve slezinách léčených zvířat. Jejich akumulace by mohla být zodpověná za zvýšení imunitní odpověďi po adjuvantní léčbě pomocí IL-12. (cs)
- In this model, upregulation of cytokine production was detected, compared to the animals without tumours. But, no differences in Th1/Th2 polarization of the immune responses were observed. In the spleens of TC-1 (MHC class I+) but not of TC-1/A9 (MHC class I–) treated tumour-bearing animals, the cytotoxic CD8+ cells were found. In the spleens of TC-1/A9 but not of TC-1 tumour-treated animals, the NK activity measured as the lysis of NK-sensitive YAC-1 targets was detected. Downregulation of the CD4+ and CD8+ subpopulations were not restored after therapy. The percentage of CD25+/CD4+ T regulatory cells in lymph nodes remained unchanged. The chemotherapy led to upregulation of immunosuppressive immature myeloid Gr-1+/CD11b+ (IMC) cells in the spleens of treated animals. The accumulation of IMC was significantly decreased after subsequent IL-12 immunotherapy. That elimination may be responsible for the improvement of antitumour responses after adjuvant IL-12 vaccination.
- In this model, upregulation of cytokine production was detected, compared to the animals without tumours. But, no differences in Th1/Th2 polarization of the immune responses were observed. In the spleens of TC-1 (MHC class I+) but not of TC-1/A9 (MHC class I–) treated tumour-bearing animals, the cytotoxic CD8+ cells were found. In the spleens of TC-1/A9 but not of TC-1 tumour-treated animals, the NK activity measured as the lysis of NK-sensitive YAC-1 targets was detected. Downregulation of the CD4+ and CD8+ subpopulations were not restored after therapy. The percentage of CD25+/CD4+ T regulatory cells in lymph nodes remained unchanged. The chemotherapy led to upregulation of immunosuppressive immature myeloid Gr-1+/CD11b+ (IMC) cells in the spleens of treated animals. The accumulation of IMC was significantly decreased after subsequent IL-12 immunotherapy. That elimination may be responsible for the improvement of antitumour responses after adjuvant IL-12 vaccination. (en)
|
| Title
| - IL-12 immunotherapy of minimal residual disease in murine models of HPV16-associated tumours: induction of immune responses, cytokine production and kinetics of immune cell subsets
- IL-12 immunotherapy of minimal residual disease in murine models of HPV16-associated tumours: induction of immune responses, cytokine production and kinetics of immune cell subsets (en)
- Imunoterapie minimální zbytkové choroby interleukinem 12 na myším modelu nádorů asociovaných s virem HPV 16: Indukce imunitní odpovědi, produkce cytokinů a kinetika subpopulací imunních buněk (cs)
|
| skos:prefLabel
| - IL-12 immunotherapy of minimal residual disease in murine models of HPV16-associated tumours: induction of immune responses, cytokine production and kinetics of immune cell subsets
- IL-12 immunotherapy of minimal residual disease in murine models of HPV16-associated tumours: induction of immune responses, cytokine production and kinetics of immune cell subsets (en)
- Imunoterapie minimální zbytkové choroby interleukinem 12 na myším modelu nádorů asociovaných s virem HPV 16: Indukce imunitní odpovědi, produkce cytokinů a kinetika subpopulací imunních buněk (cs)
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| skos:notation
| - RIV/68378050:_____/08:00306790!RIV09-AV0-68378050
|
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - P(GA301/06/0774), Z(AV0Z50520514)
|
| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
| |
| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/68378050:_____/08:00306790
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - HPV 16; MHC class I-positive and -deficient tumours; immature myeloid cells (en)
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| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| |
| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| - International Journal of Oncology
|
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Reiniš, Milan
- Bieblová, Jana
- Bubeník, Jan
- Indrová, Marie
|
| http://linked.open...ain/vavai/riv/wos
| |
| http://linked.open...n/vavai/riv/zamer
| |
| issn
| |
| number of pages
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| is http://linked.open...avai/riv/vysledek
of | |
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