About: The effect of flavonoid derivatives on doxorubicin transport and metabolism

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	This study investigated the effect of naturally occurring flavonoids and synthetic aurone derivatives on the formation of cardiotoxic doxorubicinol and transport of doxorubicin in breast cancer cells. Quercetin significantly inhibited the formation of doxorubicinol. Quercetin and aurones did not significantly affect transport of [C-14] doxorubicin in human resistant breast cancer cells. In conclusion, quercetin should be further tested for its potency to decrease doxorubicin-mediated toxicity. This study investigated the effect of naturally occurring flavonoids and synthetic aurone derivatives on the formation of cardiotoxic doxorubicinol and transport of doxorubicin in breast cancer cells. Quercetin significantly inhibited the formation of doxorubicinol. Quercetin and aurones did not significantly affect transport of [C-14] doxorubicin in human resistant breast cancer cells. In conclusion, quercetin should be further tested for its potency to decrease doxorubicin-mediated toxicity. (en)
Title	The effect of flavonoid derivatives on doxorubicin transport and metabolism The effect of flavonoid derivatives on doxorubicin transport and metabolism (en)
skos:prefLabel	The effect of flavonoid derivatives on doxorubicin transport and metabolism The effect of flavonoid derivatives on doxorubicin transport and metabolism (en)
skos:notation	RIV/00216208:11120/08:00002198!RIV11-MSM-11120___
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(GP305/07/P347), P(NR9426), S, Z(AV0Z40320502), Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Kondrová, Eliška
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	365084
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/08:00002198
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	High-Affinity Binding; Breast-Cancer Cells; P-Glycoprotein; Multidrug-Resistance; Liver-Microsomes; Drug-Resistance; Rat-Liver; Quercetin; Cardiotoxicity; Cytotoxicity (en)
http://linked.open.../riv/klicoveSlovo	Breast-Cancer Cells Cardiotoxicity Cytotoxicity Quercetin Drug-Resistance High-Affinity Binding Liver-Microsomes Multidrug-Resistance P-Glycoprotein Rat-Liver
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[2A938570E9B3]
http://linked.open...i/riv/nazevZdroje	Bioorganic & Medicinal Chemistry
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Influence of transport and metabolism of used and novel taxanes on effects and their mechanisms in patients and tumor cell lines Complex analysis of role of MDR1 gene in breast tumor resistance
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	16
http://linked.open...iv/tvurceVysledku	Kondrová, Eliška Vaclavíková, Radka
http://linked.open...ain/vavai/riv/wos	000254080900038
http://linked.open...n/vavai/riv/zamer	Design, syntéza a charakterizace klastrů, kompozitů, komplexů a dalších sloučenin na bázi anorganických látek; mechanismy a kinetika jejich interakcí Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů
issn	0968-0896
number of pages	9 (xsd:int)
http://localhost/t...ganizacniJednotka	11120
is http://linked.open...avai/riv/vysledek of	The effect of flavonoid derivatives on doxorubicin transport and metabolism The effect of flavonoid derivatives on doxorubicin transport and metabolism The effect of flavonoid derivatives on doxorubicin transport and metabolism

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