About: Regulation of microtubule nucleation from membranes by complexes of membrane-bound gamma-tubulin with Fyn kinase and phosphoinositide 3-kinase

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About: Regulation of microtubule nucleation from membranes by complexes of membrane-bound gamma-tubulin with Fyn kinase and phosphoinositide 3-kinase Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We demonstrated that membrane-associated gamma-tubulin complexes are capable of initiating the formation of microtubules. The combined results of immunoprecipitation experiments, in vitro kinase asssays and pull-down experiments suggest that gamma-tubulin interacts with PI3K directly and that Fyn and PI3K might take part in the modulation of membrane-associated gamma-tubulin activities. We demonstrated that membrane-associated gamma-tubulin complexes are capable of initiating the formation of microtubules. The combined results of immunoprecipitation experiments, in vitro kinase asssays and pull-down experiments suggest that gamma-tubulin interacts with PI3K directly and that Fyn and PI3K might take part in the modulation of membrane-associated gamma-tubulin activities. (en) Ukázali jsme, že membránově vázané komplexy gama-tubulinu umožňují iniciaci tvorby mikrotubulů. Z výsledků vyplývá, že Fyn a PI3K mohou hrát roli v modulaci aktivity mebránově vázaného gama-tubulinu. (cs)
Title	Regulation of microtubule nucleation from membranes by complexes of membrane-bound gamma-tubulin with Fyn kinase and phosphoinositide 3-kinase Regulation of microtubule nucleation from membranes by complexes of membrane-bound gamma-tubulin with Fyn kinase and phosphoinositide 3-kinase (en) Regulace nukleace mikrotubulů z membrán pomocí komplexu membránově vázaného gama-tubulinu s Fyn kinázou a PI3 kinázou (cs)
skos:prefLabel	Regulation of microtubule nucleation from membranes by complexes of membrane-bound gamma-tubulin with Fyn kinase and phosphoinositide 3-kinase Regulation of microtubule nucleation from membranes by complexes of membrane-bound gamma-tubulin with Fyn kinase and phosphoinositide 3-kinase (en) Regulace nukleace mikrotubulů z membrán pomocí komplexu membránově vázaného gama-tubulinu s Fyn kinázou a PI3 kinázou (cs)
skos:notation	RIV/68378050:_____/08:00313075!RIV09-AV0-68378050
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0520), P(GA204/05/2375), P(GA304/04/1273), P(LC545), Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Macůrek, Libor Dráber, Pavel Sládková, Vladimíra Dráberová, Eduarda Sulimenko, Tetyana Dráberová, Lubica Sulimenko, Vadym Vosecká, Věra
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	392057
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/08:00313075
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	detergent-resistant membrane; Fyn; PI3K gamma-tubulin (en)
http://linked.open.../riv/klicoveSlovo	Fyn PI3K gamma-tubulin detergent-resistant membrane
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[34E109E3FEAB]
http://linked.open...i/riv/nazevZdroje	Biochemical Journal
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	8 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Center for Applied Genomics Functional Organisation of the Cell Analysis of gama-tubulin forms and other spindle pole components Analysis and regulation of gamma-tubulin forms associated with membrane microdomains
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	416
http://linked.open...iv/tvurceVysledku	Macůrek, Libor Dráber, Pavel Dráberová, Eduarda Sulimenko, Tetyana Dráberová, Lubica Sulimenko, Vadym Marková, Vladimíra Richterová, Věra
http://linked.open...ain/vavai/riv/wos	000261781500011
http://linked.open...n/vavai/riv/zamer	Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů
issn	0264-6021
number of pages	10 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Regulation of microtubule nucleation from membranes by complexes of membrane-bound gamma-tubulin with Fyn kinase and phosphoinositide 3-kinase Regulation of microtubule nucleation from membranes by complexes of membrane-bound gamma-tubulin with Fyn kinase and phosphoinositide 3-kinase

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