About: Functional Organisation of the Cell

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/domain/vavai/Projekt
rdfs:seeAlso	http://www.isvav.cz/projectDetail.do?rowId=LC545
Description	Establishing the roles of complexes of nuclear actin, myosin and PML in gene expression and formation of nuclear architecture. Characterization of protein complexes of tubulins and their roles in organization of mitotic apparatus, interactions with membranes and establishing cellular polarity. Determination of transport mechanism of integral proteins towards the cell membrane. To clarify how cytoskeletal interactions of eIF3 translation complex participate in localized translation and dynamics of stress granules. To determine the function of chromatin remodeller Isw2-Itc1 in the cell cycle and stress. Description of protein topology in biological membranes using specific markers. Technique development for characterization of protein complexes using electrospray on ionic cyclotron. To identify the endocytotic pathway used by polyomaviruses for transporting their genomes to the cell nucleus, and the cellular protective mechanisms leading the virus to degradation pathways. To describe cellular structures involved in virion morphogenesis. (en) Zjistit úlohu komplexů jaderného aktinu, myosinu a PML v genové expresi a tvorbě architektury jádra. Charakterizovat proteinové komplexy tubulinů a objasnit jejich roli v organizaci mitotického aparátu, interakcích s membránami a při určování polarity buněk. Objasnit mechanismus dopravování integrálních bílkovin do plazmatické membrány. Objasnit podíl cytoskeletálních interakcí eIF3 translačního komplexu na lokalizované translaci a dynamice stresových granulí. Objasnit funkci komplexu Isw2-Itc1, který remoduluje chromatin, v průběhu buněčného cyklu a při reakci na stres. Určit topologii proteinů v biologických membránách pomocí specifického značení. Vyvinout metodiku pro charakterizaci vysokomolekulárních komplexů s použitím elektrospreje na iontovém cyklotronu. Identifikovat endocytickou dráhu používanou polyomaviry pro dopravu jejich genomů do buněčného jádra a obranné buněčné mechanismy, svádějící virové částice na degradační dráhy. Porozumět mechanismu morfogenese virionů a identifikovat buněčné funkce, které se tohoto procesu účastní.
Title	Functional Organisation of the Cell (en) Centrum funkční organizace buňky
skos:notation	LC545
http://linked.open...avai/cep/aktivita	Basic Research Centres
http://linked.open...kovaStatniPodpora	http://linked.opendata.cz/resource/domain/vavai/projekt/LC545/celkovaStatniPodpora
http://linked.open...ep/celkoveNaklady	http://linked.opendata.cz/resource/domain/vavai/projekt/LC545/celkoveNaklady
http://linked.open...datumDodatniDoRIV	2012-07-03 (xsd:date)
http://linked.open...i/cep/druhSouteze	VS - Veřejná soutěž ve výzkumu a vývoji
http://linked.open...ep/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open.../cep/fazeProjektu	91885026
http://linked.open...ai/cep/hlavniObor	EA - Morfologické obory a cytologie
http://linked.open...hodnoceniProjektu	V - Vynikající výsledky (s mezinárodním významem apod.). Zároveň byly splněny cíle a předpokládané výsledky uvedené ve smlouvě / rozhodnutí o poskytnutí podpory.
http://linked.open...vai/cep/kategorie	ZV - Základní výzkum
http://linked.open.../cep/klicovaSlova	cell, nucleus, cytoskeleton, compartmentalization, cellular trafficking, gene expression, virus infection, cell cycle, cellular senescence (en)
http://linked.open...ep/partnetrHlavni	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...inujicichPrijemcu	1 (xsd:int)
http://linked.open...cep/pocetPrijemcu	3 (xsd:int)
http://linked.open...ocetSpoluPrijemcu	0 (xsd:int)
http://linked.open.../pocetVysledkuRIV	107 (xsd:int)
http://linked.open...enychVysledkuVRIV	107 (xsd:int)
http://linked.open...lneniVMinulemRoce	2011-02-11 (xsd:date)
http://linked.open.../prideleniPodpory	http://linked.opendata.cz/resource/domain/vavai/cep/prideleniPodpory/32341%2F2010-31
http://linked.open...iciPoslednihoRoku	2011
http://linked.open...atUdajeProjZameru	2012
http://linked.open.../vavai/cep/soutez	SMSM200400LC1
http://linked.open...usZobrazovaneFaze	DUU
http://linked.open...ai/cep/typPojektu	P - Projekt výzkumu a vývoje financovaný ze státního rozpočtu
http://linked.open...ep/ukonceniReseni	2011-12-31 (xsd:date)
http://linked.open.../cep/vedlejsiObor	CE - Biochemie EB - Genetika a molekulární biologie
http://linked.open...ep/zahajeniReseni	2005-02-01 (xsd:date)
http://linked.open...jektu+dodavatelem	The Centre formed a top research environment, improved PhD study system, and enhanced the international collaboration. Studies on the molecular mechanisms of cytoskeleton functioning during the cell cycle, the cell nucleus compartmentalization and interactions with polyoma virus resulted in 137 published articles, 96 posters and 54 lectures at conferences with active participation of 40 students. (en) Centrum vytvořilo ucelené špičkové metodické zázemí, zkvalitnilo výchovu PhD studentů a rozšířilo zahraniční spolupráci při poznání molekulárních mechanismů fungování cytoskeletu v průběhu buněčného cyklu, funkčních struktur buněčného jádra a interakcí s polyomavirem. Výsledky projektu zahrnují 137 publikovaných článků, 96 posterů a 54 přednášek na konferencích s aktivní účastí 40 studentů (cs)
http://linked.open...tniCyklusProjektu	ZBBBBBKU
http://linked.open.../cep/klicoveSlovo	cell cell cycle cytoskeleton gene expression nucleus cellular trafficking compartmentalization virus infection
is http://linked.open...vavai/riv/projekt of	γ-Tubulin 2 nucleates microtubules and is downregulated in mouse early embryogenesis Involvement of phosphatidylinositol 4,5-bisphosphate in RNA polymerase I transcription Engagement of phospholipid scramblase 1 in activated cells: implication for phosphatidylserine externalization and exocytosis Cellular and humoral immune responses to chimeric EGFP-pseudocapsids derived from the mouse polyomavirus after their intranasal administration Regulation of microtubule nucleation from membranes by complexes of membrane-bound gamma-tubulin with Fyn kinase and phosphoinositide 3-kinase Tyrosine phosphorylation of plant tubulin Class III beta-tubulin is constitutively coexpressed with glial fibrillary acidic protein and nestin in midgestational human fetal astrocytes: implications for phenotypic identity Gamma-tubulins and Their functions in plant cells Ultrastructural localization of actin and actin-binding proteins in the nucleus Tubulin targets in the pathobiology and therapy of glioblastoma multiforme. II. Gamma-tubulin Vacuolin-1-modulated exocytosis and cell resealing in mast cells Optimalization of immunogold labeling on thin resin sections after cryofixation Cytokine expression and signaling in drug-induced cellular senescence Recovery of tubulin functions after freeze-dying in the presence of trehalose Down-regulation of protein-tyrosine phosphatases activates an immune receptor in the absence of its translocation into lipid rafts Exposure of beta-tubulin regions defined by antibodies on an Arabidopsis thaliana microtubule protofilament model and in the cells Transcription-dependent rearrangements of actin and nuclear myosin I in the nucleolus Actin complexes in the cell nucleus: new stones in an old field What precedes the initial tyrosine phosphorylation of the high affinity IgE receptor in antigen-activated mast cell? The transmembrane adaptor protein NTAL signals to mast cell cytoskeleton via the small GTPase Rho Comparison of methods of high-pressure freezing and automated freeze-substitution of suspension cells combined with LR White embedding Ultrastructural and nuclear antigen preservation after high-pressure freezing/freeze-substitution and low-temperature LR White embedding of HeLa cells Bcr-Abl fusion sequences do not induce immune responses in mice when administeredin mouse polyomavirus based virus-like particles Minor capsid proteins of mouse polyomavirus are inducers of apoptosis when produced individually but are only moderate centributors to cell death during the late phase of viral infection MSTools-Web based application for visualization and presentation of HXMS data Scanning electron microscopic imaging of surface effects in desorption and nano-desorption electrospray ionization Reproductive tissue expression and sperm localization of porcine beta-microseminoprotein STIM1-Directed Reorganization of Microtubules in Activated Mast Cells The actin family member Arp6 and the histone variant H2A.Z are required for spatial positioning of chromatin in chicken cell nuclei Interactions of an Arabidopsis RanBPM homologue with LisH-CTLH domain proteins revealed high conservation of CTLH complexes in eukaryotes The microarchitecture of DNA replication domains Functional structure of the cell nucleus Separation of nuclear protein complexes by blue native polyacrylamide gel electrophoresis Membrane potential governs lateral segregation of plasma membrane proteins and lipids in yeast Assemblages of simian virus 40 capsid proteins and viral DNA visualized by electron microscopy Multiple tubulin forms in ciliated protozoan Tetrahymena and Paramecium species DSE1p overproduction and its influence on polarity proteins in Saccharomyces cerevisia Chromosomal dynamics of cell cycle regulator gene p21 during transcriptional activation Microtubules The maternal nucleolus is essential for early embryonic development in mammals The time-course of agonist-induced solubilization of trimeric Gqalpha/G11alpha proteins resolved by two-dimensional electrophoresis 1H, 13C, and 15N Resonance Assignment of the N-terminal Domain of Mason-Pfizer Monkey Virus Capsid Protein, CA1-140. Soluble recombinant CD69 receptors optimized to have an exceptional physical and chemicsl stability display prolonged circulation and remain intact in the blood of mice NMR Structure of the N-Terminal Domain of Capsid Protein from the Mason-Pfizer Monkey Virus Time-Dependent Oxidation during Nano-Assisted Laser Desorption Ionization Mass Spectrometry: A Useful Tool for Structure Determination or a Source of Possible Confusion? Plant Aurora kinases play a role in maintenance of primary meristems and control of endoreduplication Quantitative evaluation of freeze-substitution effects on preservation of nuclear antigens during preparation of biological samples for immunoelectron microscopy Polyomavirus EGFP-pseudocapsids: Analysis of model particles for introduction of proteins and peptides into mammalian cells A nodulin/glutamine synthetase-like fusion protein is implicated in the regulation of root morphogenesis and in signalling triggered by flagellin A method for preserving ultrastructural properties of mitotic cells for subsequent immunogold labeling using low-temperature embedding in LR White resin Chemical cross-linking and H/D exchange for fast refinement of protein crystal structure Specific nuclear localizing sequence directs two myosin isoforms to the cell nucleus in calmodulin-sensitive manner Molecular cloning of three pyranose dehydrogenase-encoding genes from Agaricus meleagris and analysis of their expression by real-time RT-PCR Disrupting Vesicular Trafficking at the Endosome Attenuates Transcriptional Activation by Gcn4

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