About: Transcription-dependent rearrangements of actin and nuclear myosin I in the nucleolus

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Nuclear actin and nuclear myosin I (NMI) are important players in transcription of ribosomal genes. Transcription of rDNA takes place in highly organized intranuclear compartment, the nucleolus. In this study, we characterized the localization of these two proteins within the nucleolus of HeLa cells with high structural resolution by means of electron microscopy and gold-immunolabeling. We demonstrate that both actin and NMI are localized in specific compartments within the nucleolus, and the distribution of NMI is transcription-dependent. Moreover, a pool of NMI is present in the foci containing nascent rRNA transcripts. Actin, in turn, is present both in transcriptionally active and inactive regions of the nucleolus and colocalizes with RNA polymerase I and UBF. Our data support the involvement of actin and NMI in rDNA transcription and point out to other functions of these proteins in the nucleolus, such as rRNA maturation and maintenance of nucleolar architecture. Nuclear actin and nuclear myosin I (NMI) are important players in transcription of ribosomal genes. Transcription of rDNA takes place in highly organized intranuclear compartment, the nucleolus. In this study, we characterized the localization of these two proteins within the nucleolus of HeLa cells with high structural resolution by means of electron microscopy and gold-immunolabeling. We demonstrate that both actin and NMI are localized in specific compartments within the nucleolus, and the distribution of NMI is transcription-dependent. Moreover, a pool of NMI is present in the foci containing nascent rRNA transcripts. Actin, in turn, is present both in transcriptionally active and inactive regions of the nucleolus and colocalizes with RNA polymerase I and UBF. Our data support the involvement of actin and NMI in rDNA transcription and point out to other functions of these proteins in the nucleolus, such as rRNA maturation and maintenance of nucleolar architecture. (en)
Title	Transcription-dependent rearrangements of actin and nuclear myosin I in the nucleolus Transcription-dependent rearrangements of actin and nuclear myosin I in the nucleolus (en)
skos:prefLabel	Transcription-dependent rearrangements of actin and nuclear myosin I in the nucleolus Transcription-dependent rearrangements of actin and nuclear myosin I in the nucleolus (en)
skos:notation	RIV/68378050:_____/10:00351320!RIV11-GA0-68378050
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(2B06063), P(GA204/07/1592), P(LC545), P(ME09101), Z(AV0Z50110509), Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Hozák, Pavel Philimonenko, Vlada
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	293277
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/10:00351320
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	RNA-polymerase-I; ultrastructural analysis; UBF (en)
http://linked.open.../riv/klicoveSlovo	RNA-polymerase-I ultrastructural analysis UBF
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[10DB9E6271C1]
http://linked.open...i/riv/nazevZdroje	Histochemistry and Cell Biology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Structure and irregularities of the nucleoskeleton: identification and diagnostics. Functional Organisation of the Cell Cooperative contribution of actin- and myosin-families to the chromatin dynamics and tranion in the cell nucleus Functions of nuclear myosin in gene expression
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	134
http://linked.open...iv/tvurceVysledku	Hozák, Pavel Janáček, Jiří Harata, M. Philimonenko, Vlada
http://linked.open...ain/vavai/riv/wos	000281249500002
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů
issn	0948-6143
number of pages	7 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Transcription-dependent rearrangements of actin and nuclear myosin I in the nucleolus

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