About: The transmembrane adaptor protein NTAL signals to mast cell cytoskeleton via the small GTPase Rho

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About: The transmembrane adaptor protein NTAL signals to mast cell cytoskeleton via the small GTPase Rho Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The transmembrane adaptor protein NTAL participates in signalosome assembly in hematopoietic cells, but its exact role in cell physiology remains enigmatic. This study shows that mast cells from NTAL-deficient mice, responding to Ag alone or in combination with SCF, exhibit reduced spreading on fibronectin, enhanced filamentous actin depolymerization and enhanced migration towards Ag relative to WT cells. No such differences between WT and NTAL(-/-) cells were observed when SCF alone was used as activator. Next the activities of two small GTPases, Rac and Rho, which are important regulators of actin polymerization were examined. Stimulation with Ag and/or SCF enhanced activity of Rac (1,2,3) in both NTAL(-/-) and WT cells. In contrast, RhoA activity decreased and this trend was much faster and more extensive in NTAL(-/-) cells, indicating a positive regulatory role of NTAL in the recovery of RhoA activity. The transmembrane adaptor protein NTAL participates in signalosome assembly in hematopoietic cells, but its exact role in cell physiology remains enigmatic. This study shows that mast cells from NTAL-deficient mice, responding to Ag alone or in combination with SCF, exhibit reduced spreading on fibronectin, enhanced filamentous actin depolymerization and enhanced migration towards Ag relative to WT cells. No such differences between WT and NTAL(-/-) cells were observed when SCF alone was used as activator. Next the activities of two small GTPases, Rac and Rho, which are important regulators of actin polymerization were examined. Stimulation with Ag and/or SCF enhanced activity of Rac (1,2,3) in both NTAL(-/-) and WT cells. In contrast, RhoA activity decreased and this trend was much faster and more extensive in NTAL(-/-) cells, indicating a positive regulatory role of NTAL in the recovery of RhoA activity. (en)
Title	The transmembrane adaptor protein NTAL signals to mast cell cytoskeleton via the small GTPase Rho The transmembrane adaptor protein NTAL signals to mast cell cytoskeleton via the small GTPase Rho (en)
skos:prefLabel	The transmembrane adaptor protein NTAL signals to mast cell cytoskeleton via the small GTPase Rho The transmembrane adaptor protein NTAL signals to mast cell cytoskeleton via the small GTPase Rho (en)
skos:notation	RIV/68378050:_____/10:00353421!RIV11-GA0-68378050
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0506), P(GA301/09/1826), P(GAP302/10/1759), P(GD204/05/H023), P(KAN200520701), P(LC545), Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika	11
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Tůmová, Magda Koffer, Anna Šimíček, Michal Dráber, Petr Dráberová, Lubica
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	293355
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/10:00353421
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cell activation; cytoskeleton; mast cells (en)
http://linked.open.../riv/klicoveSlovo	cytoskeleton cell activation mast cells
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[37E680527D50]
http://linked.open...i/riv/nazevZdroje	European Journal of Immunology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Functional Organisation of the Cell Center of Molecular and Cellular Immunology Nano-PCR - ultrasensitive test for detection of specific proteins in body fluids Molecular biology of differentiating cell Topography and function of Csk-binding proteins of the plasma membrane in mast cells Function-structure relationships between transmembrane adaptor-based signalosomes in mast cells
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	40
http://linked.open...iv/tvurceVysledku	Dráber, Petr Dráberová, Lubica Koffer, Anna Tůmová, Magda Šimíček, Michal
http://linked.open...ain/vavai/riv/wos	000284059000028
http://linked.open...n/vavai/riv/zamer	Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů
issn	0014-2980
number of pages	11 (xsd:int)
is http://linked.open...avai/riv/vysledek of	The transmembrane adaptor protein NTAL signals to mast cell cytoskeleton via the small GTPase Rho

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