About: Center for Applied Genomics

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/domain/vavai/Projekt
rdfs:seeAlso	http://www.isvav.cz/projectDetail.do?rowId=1M0520
Description	We propose to establish a research Center of Applied Genomics (CAG), where a high level research of genomics will be oriented towards practical applications. The program of the Center is based on the experience obtained in the Center of Integrated GenomiThe effort would be focused in CAG to two areas. The first one would be medically oriented projects aimed particularly at new diagnostic methods and the second one on projects targeted to the topic of the environment. Both these areas were already develoAn example of such an ongoing CIG project is construction of a mitochip on which oligonucleotide markers of all genes of the human mitochondrion are anchored. With regard to the long-term program of the study of inherited mitochondrial diseases performedAdvantageous is here experience with these diseases as well as a comprehensive register of patients in the Czech Republic and abroad. Another example of a well-developed topic is the study of bacterial genes determining degradation of catechols and synt (en) Navrhujeme vytvořit výzkumné Centrum aplikované genomiky (CAG), v němž se skloubí vysoká úroveň genomického výzkumu s výzkumem orientovaným na praktické aplikace. Program Centra je založen na zkušenostech získaných v Centru integrované genomiky (CIG) v lV CAG by se úsilí soustředilo do dvou oblastí. Jednak by to byly lékařsky orientované projekty, zaměřené zejména na nové diagnostické metody, a dále projekty cílené do problematiky životního prostředí. Oba tyto směry jsou právě díky CIG rozpracovány a doJako příklad takového projektu již řešeného v CIG lze uvést konstrukci mitočipu, na němž jsou zakotveny oligonukleotidové značky všech genů lidské mitochondrie. Vzhledem k dlouhodobému programu studia dědičných mitochondriálních chorob na 1. LF UK a na FVýhodou je zde nejen zkušenost s těmito chorobami ale i dokonalý přehled o pacientech v ČR i v zahraničí). Jiným příkladem rozvinuté tematiky je studium bakteriálních genů determinujících jednak degradaci katecholů a též syntézu polyhydroxyalkanoátů).
Title	Center for Applied Genomics (en) Centrum aplikované genomiky
skos:notation	1M0520
http://linked.open...avai/cep/aktivita	The research centres (National research program)
http://linked.open...kovaStatniPodpora	http://linked.opendata.cz/resource/domain/vavai/projekt/1M0520/celkovaStatniPodpora
http://linked.open...ep/celkoveNaklady	http://linked.opendata.cz/resource/domain/vavai/projekt/1M0520/celkoveNaklady
http://linked.open...datumDodatniDoRIV	2012-07-03 (xsd:date)
http://linked.open...i/cep/druhSouteze	VS - Veřejná soutěž ve výzkumu a vývoji
http://linked.open...ep/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open.../cep/fazeProjektu	91900115
http://linked.open...ai/cep/hlavniObor	EB - Genetika a molekulární biologie
http://linked.open...hodnoceniProjektu	V - Vynikající výsledky (s mezinárodním významem apod.). Zároveň byly splněny cíle a předpokládané výsledky uvedené ve smlouvě / rozhodnutí o poskytnutí podpory.
http://linked.open...vai/cep/kategorie	AP - Aplikovaný výzkum
http://linked.open.../cep/klicovaSlova	Genomics, proteomics, microarrays, bioremediation, inborn errors, mitochondria (en)
http://linked.open...ep/partnetrHlavni	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...inujicichPrijemcu	0 (xsd:int)
http://linked.open...cep/pocetPrijemcu	1 (xsd:int)
http://linked.open...ocetSpoluPrijemcu	3 (xsd:int)
http://linked.open.../pocetVysledkuRIV	299 (xsd:int)
http://linked.open...enychVysledkuVRIV	299 (xsd:int)
http://linked.open...lneniVMinulemRoce	2011-02-03 (xsd:date)
http://linked.open.../prideleniPodpory	http://linked.opendata.cz/resource/domain/vavai/cep/prideleniPodpory/14%2F2010-31
http://linked.open...iciPoslednihoRoku	2011
http://linked.open...atUdajeProjZameru	2012
http://linked.open.../vavai/cep/soutez	SMSM2005001M1
http://linked.open...usZobrazovaneFaze	DUU
http://linked.open...ai/cep/typPojektu	P - Projekt výzkumu a vývoje financovaný ze státního rozpočtu
http://linked.open...ep/ukonceniReseni	2011-12-31 (xsd:date)
http://linked.open.../cep/vedlejsiObor	CE - Biochemie
http://linked.open...ep/zahajeniReseni	2005-01-01 (xsd:date)
http://linked.open...jektu+dodavatelem	Using methods of functional genomics molecular changes leading to several diseases were characterized. In particular this applies to porphyrias, juvenile nephropaties and diseases connected with ATP synthesis. New methods were developed for gene transfer to cells. They are based on envelope proteins of selected retroviruses. The results are subjects of excellent scientific papers and patents (en) Metodami funkční genomiky byly charakterizovány příčiny několika dědičných chorob, zejména porfyrií, juvenilních nefropatií a chorob spojených se syntézou ATP. Podařilo se vyvinout nové metody vnášení genů do buněk. Tyto metody využívají obalu některých retrovirů. Výsledky jsou součástí prestižních mezinárodních publikací a patentů. (cs)
http://linked.open...tniCyklusProjektu	ZBBBKBKU
http://linked.open.../cep/klicoveSlovo	Genomics bioremediation microarrays proteomics inborn errors
is http://linked.open...vavai/riv/projekt of	Interallelic and intergenic incompatibilities of the Prdm9 (Hst1) gene in mouse hybrid sterility Biosorption of Cd2+ and Zn2+ by cell surface-engineered Saccharomyces cerevisiae. Cílený posun čtecího rámce - translace alternativních produktů The impact of altered polyprotein ratios on the assembly and infectivity of Mason-Pfizer monkey virus. Conserved and Variable Features of Gag Structure and Arrangement in Immature Retrovirus Part Surface display of metal fixation motif of bacterial P1-ATPases specifically promotes biosorption of Pb2+ by Saccharomyces cerevisiae Nonmyristoylated Matrix Protein from the Mason-Pfizer Monkey Virus Forms Oligomers Mechanistic basis of infertility of mouse intersubspecific hybrids Electrophilic polyfluoroalkylating agents based on sulfonate esters The effect of point mutations within the N-terminal domain of Mason-Pfizer monkey virus capsid protein on virus core assembly and infectivity Genetically modified plants in phytoremediation of heavy metal and metalloid soil and sediment pollution Mouse consomic strains: Exploiting genetic divergence between Mus m. musculus and Mus m. domesticus subspecies Fine haplotype structure of a chromosome 17 region in the laboratory and wild mouse Nucleotide sequence, organization and characterization of the (halo)aromatic acid catabolic plasmid pA81 from Achromobacter xylosoxidans A8 Eye evolution: lens and cornea as an upgrade of animal visual system The role of Pax genes in eye evolution Cubozoan crystallins: evidence for convergent evolution of Pax regulatory sequences Regulation of microtubule nucleation from membranes by complexes of membrane-bound gamma-tubulin with Fyn kinase and phosphoinositide 3-kinase Optical sensing of sulfate by polymethinium salt receptors: colorimetric sensor for heparin HIF and reactive oxygen species regulate oxidative phosphorylation in cancer Assembly of the cnidarian camera-type eye from vertebrate-like components The amphioxus genome illuminates vertebrate origins and cephalochordate biology DNA variation within Juncaceae: Comparison of impact of organelle regions on phylogeny Analysis of nrDNA polymorphism in closely related diploid sexual, tetraploid sexual and polyploid agamospermous species Eye evolution: common use and independent recruitment of genetic components Eye-specific expression of an ancestral jellyfish PaxB gene interferes with Pax6 function despite its conserved Pax6/Pax2 characteristics Spatial and temporal regulation of Wnt/beta-catenin signaling is essential for development of the retinal pigment epithelium A lens-specific co-injection marker for medaka transgenesis Lens morphogenesis is dependent on Pax6-mediated inhibition of the canonical Wnt/beta-catenin signaling in the lens surface ectoderm Complete genome sequence of the photosynthetic purple nonsulfur bacterium Rhodobacter capsulatus SB 1003 Loss of the response regulator CtrA causes pleiotropic effects on gene expression but does not affect growth phase regulation in Rhodobacter capsulatus Selective recognition of a saccharide-type tumor marker with natural and synthetic ligands: a new trend in cancer diagnosis Long-term pioglitazone treatment augments insulin sensitivity and PKC-epsilon and PKC-theta activation in skeletal muscles in sucrose fed rats Succinimidyl oleate, established inhibitor of CD36/FAT translocase inhibits complex III of mitochondrial respiratory chain Bacterial Surface Display of Metal-Binding Sites Expression and purification of myristoylated matrix protein of Mason-Pfizer monkey virus for NMR and MS measurements Expression and processing of the TMEM70 protein Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function Evaluation of basic mitochondrial functions using rat tissue homogenates Improved Synthesis of Chiral Pyrrolidine Inhibitors and Their Binding Properties to Neuronal Nitric Oxide Synthase Molecular characterization of the AdeI mutant of Chinese hamster ovary cells: A cellular model of adenylosuccinate lyase deficiency Mutations in DNAJC5, Encoding Cysteine-String Protein Alpha, Cause Autosomal-Dominant Adult-Onset Neuronal Ceroid Lipofuscinosis Mouse 3T3 fibroblasts under the influence of fibroblasts isolated from stroma of human basal cell carcinoma acquire properties of multipotent stem cells Uromodulin-Associated Kidney Disease An unexpected gene cluster for downstream degradation of alkylphenols in Sphingomonas sp strain TTNP3 CD36 overexpression predisposes to arrhythmias but reduces infarct size in spontaneously hypertensive rats: gene expression profile analysis Structure-Guided Design of Selective Inhibitors of Neuronal Nitric Oxide Synthase Distinct Roles for Nucleic Acid in In Vitro Assembly of Purified Mason-Pfizer Monkey Virus CANC Proteins Cílený posun čtecího rámce - translace alternativních produktů Atomic Force microscopy investigation of Mason-Pfizer monkey virus and human immunodeficiency virus type 1 reassembled particles Biologické složky bionsenzorů pro těžké kovy Actual approaches in environmental ecotoxicology Molekulární charakterizace mikrobiálních NAD(P) a Zn-dependentních alkohol dehydrogenas The Role of the S-S Bridge in Retroviral Protease Function and Virion Maturation Využití retrovirových částic pro terapeutické účely Fumaric aciduria: Mild phenotype in a 8-year-old girl with novel mutations A novel insertion of a rearranged L1 element in exon 44 og the dystrophin gene: Further evidence for possible bias in retroposon integration Ultrastructural changes of mitochondria in the cultivated skin fibroblasts of patients with point mutations in mitochondrial DNA

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