| Attributes | Values |
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| rdf:type
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| Description
| - Metabotropní glutamátové receptory (mGluR) tvoří na povrchu buňky komplexy složené ze dvou identických proteinů. Metabotropní glutamátový receptor 1 existuje v několika sestřihových variantách v oblasti nitrobuněčně uloženého C-terminu. Sestřihové varianty mGluR1 dělíme na dlouhé (mGluR1a) a krátké (mGluR1b a d). V této publikaci jsme prokázali, že dlouhé varianty mohou tvořit s krátkými funkční dimery s vlastnostmi, které jsou určovány přítomností dlouhé varianty mGluR1a. (cs)
- Metabotropic glutamate receptors (mGluRs) are found commonly as homodimers. Alternative splicing of mGluR1 gene results in vivo in the expression of a long variant mGluR1a and at least two short variants mGluR1b and d. The amino acid sequences diverge within their carboxyl-termini six amino acid residues following RRKK motif. This four basic residue sequence was shown to have pronounced impact on function and trafficking of the short variants, while for mGluR1a the long C-terminus reduces the effects caused by presence of the RRKK motif. Here we investigated consequences of interactions between long mGluR1a and short mGluR1b variants. Our results show that mGluR1a interferes with mGluR1b trafficking to the cell surface in HEK293 transfected cells. Expression of a mGlu1a mutant incapable of activating G-proteins with mGluR1b mutated in the glutamate binding site led to the formation of a functional heterodimer
- Metabotropic glutamate receptors (mGluRs) are found commonly as homodimers. Alternative splicing of mGluR1 gene results in vivo in the expression of a long variant mGluR1a and at least two short variants mGluR1b and d. The amino acid sequences diverge within their carboxyl-termini six amino acid residues following RRKK motif. This four basic residue sequence was shown to have pronounced impact on function and trafficking of the short variants, while for mGluR1a the long C-terminus reduces the effects caused by presence of the RRKK motif. Here we investigated consequences of interactions between long mGluR1a and short mGluR1b variants. Our results show that mGluR1a interferes with mGluR1b trafficking to the cell surface in HEK293 transfected cells. Expression of a mGlu1a mutant incapable of activating G-proteins with mGluR1b mutated in the glutamate binding site led to the formation of a functional heterodimer (en)
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| Title
| - Surface expression of metabotropic glutamate receptor variants mGluR1a and mGluR1b in transfected HEK293 cells
- Surface expression of metabotropic glutamate receptor variants mGluR1a and mGluR1b in transfected HEK293 cells (en)
- Povrchová exprese variant metabotropního glutamátového receptoru mGluR1a a mGluR1b v transfekovaných buňkách HEK293 (cs)
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| skos:prefLabel
| - Surface expression of metabotropic glutamate receptor variants mGluR1a and mGluR1b in transfected HEK293 cells
- Surface expression of metabotropic glutamate receptor variants mGluR1a and mGluR1b in transfected HEK293 cells (en)
- Povrchová exprese variant metabotropního glutamátového receptoru mGluR1a a mGluR1b v transfekovaných buňkách HEK293 (cs)
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| skos:notation
| - RIV/68378050:_____/08:00311063!RIV09-AV0-68378050
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| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - P(GA204/05/0920), P(GA303/08/1591), P(IAA500390701), P(LC06063), Z(AV0Z50520514)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/68378050:_____/08:00311063
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| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - G-proteins; glutamate; receptor (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Blahoš, Jaroslav
- Králíková, Michaela
- Hrušková, Bohdana
- Franková, Daniela
- Hlaváčková, Veronika
- Pin, J. P.
- Prezeau, L.
- Kulihová, Lenka
- Kumpošt, Jiří
- Syrová, Zdeňka
- Bologna, J. C.
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| http://linked.open...ain/vavai/riv/wos
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| is http://linked.open...avai/riv/vysledek
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