| Attributes | Values |
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| rdf:type
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| Description
| - Při haplotypovém mapování myších kvantitativních znaků pomocí klasických laboratorních kmenů (CL) je překážkou silná vazebná nerovnováha. Zkoumali jsme proto potenciál myších kmenů recentně odvozených z divokých myší (WD). Zkonstruovali jsme haplotypovou mapu oblasti o velikosti 250 kb z t-komplexu na chromosomu 17. Tato oblast obsahuje gen Hybrid sterility 1 (Hst1). Resekvenovali jsme 33 lokusů z až 80 chromosomů pěti myších (pod)druhů. Trans-speciační jednonukleotidové polymorfismy (SNP) mezi Mus m. musculus (Mmmu) a Mus m. domesticus (Mmd) byly vzácné. Haplotypy v Mmmu, Mmd a t-chromosomech se lišily, a neměly by proto být kombinovány při haplotypovém mapování. Pouze část SNPů a přeskupů DNA nalezených v CL kmenech byla použitelná pro haplotypové mapování v Mmd. Největší haplotypový blok u Mmd pokrýval 3 geny konzervované syntenie. Haplotypové bloky u Mmd byly dlouhé desítky kb, což ukazuje, že WD Mmd kmeny jsou vhodné pro jemné intervalové mapování. (cs)
- Strong linkage disequilibrium among classical laboratory (CL) strains represents an obstacle in the haplotype mapping of mouse quantitative trait loci (QTL). To determine the potential of wild-derived (WD) mouse strains for fine QTL mapping, we constructed a haplotype map of a 250-kb region of the t-complex on Chromosome 17 containing the Hybrid sterility 1 (Hst1) gene. We resequenced 33 loci from up to 80 chromosomes of 5 mouse (sub)species. Trans-species single-nucleotide polymorphisms (SNPs) were rare between Mus m. musculus (Mmmu) and Mus m. domesticus (Mmd). The haplotypes in Mmmu, Mmd, and t-chromosomes differed and thus should not be combined for haplotype mapping. Only a subset of SNPs and rearrangements found in CL strains were useful for haplotype mapping in wild Mmd. The largest Mmd haplotype block contained 3 genes of a highly conserved synteny. The Mmd haplotype blocks were tens of kb, suggesting that the WD Mmd strains are suitable for fine interval-specific mapping.
- Strong linkage disequilibrium among classical laboratory (CL) strains represents an obstacle in the haplotype mapping of mouse quantitative trait loci (QTL). To determine the potential of wild-derived (WD) mouse strains for fine QTL mapping, we constructed a haplotype map of a 250-kb region of the t-complex on Chromosome 17 containing the Hybrid sterility 1 (Hst1) gene. We resequenced 33 loci from up to 80 chromosomes of 5 mouse (sub)species. Trans-species single-nucleotide polymorphisms (SNPs) were rare between Mus m. musculus (Mmmu) and Mus m. domesticus (Mmd). The haplotypes in Mmmu, Mmd, and t-chromosomes differed and thus should not be combined for haplotype mapping. Only a subset of SNPs and rearrangements found in CL strains were useful for haplotype mapping in wild Mmd. The largest Mmd haplotype block contained 3 genes of a highly conserved synteny. The Mmd haplotype blocks were tens of kb, suggesting that the WD Mmd strains are suitable for fine interval-specific mapping. (en)
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| Title
| - Fine haplotype structure of a chromosome 17 region in the laboratory and wild mouse
- Fine haplotype structure of a chromosome 17 region in the laboratory and wild mouse (en)
- Jemná haplotypová struktura oblasti chromosomu 17 u laboratorní a divoké myši (cs)
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| skos:prefLabel
| - Fine haplotype structure of a chromosome 17 region in the laboratory and wild mouse
- Fine haplotype structure of a chromosome 17 region in the laboratory and wild mouse (en)
- Jemná haplotypová struktura oblasti chromosomu 17 u laboratorní a divoké myši (cs)
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| skos:notation
| - RIV/68378050:_____/08:00306626!RIV09-AV0-68378050
|
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - P(1M0520), P(GA301/05/0738), P(IAA5052406), Z(AV0Z50520514)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/68378050:_____/08:00306626
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - haplotype; hybrid sterility (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| |
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Forejt, Jiří
- Gregorová, Soňa
- Vlček, Čestmír
- Trachtulec, Zdeněk
- Mihola, Ondřej
- Fotopulosová, Vladana
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| http://linked.open...ain/vavai/riv/wos
| |
| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| is http://linked.open...avai/riv/vysledek
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