About: The identity of the transcription +1 position is crucial for changes in gene expression in response to amino acid starvation in Bacillus subtilis     Goto   Sponge   NotDistinct   Permalink

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  • We identify here a pattern in the transcription start sites (+1A or +1G) of A- dependent promoters of genes that are up-/down-regulated in response to amino acid starvation (stringent response) in Bacillus subtilis. Upregulated promoters initiate mostly with ATP and downregulated promoters with GTP. These promoters appear to be sensitive to changes in initiating NTP concentrations. During the stringent response in B. subtilis, when ATP and GTP levels change reciprocally, the identity of the +1 position (A or G) of these promoters is a factor important in their regulation. Mutations that change the identity of position +1 (A for G and vice versa) change the response of the promoter to amino acid starvation.
  • We identify here a pattern in the transcription start sites (+1A or +1G) of A- dependent promoters of genes that are up-/down-regulated in response to amino acid starvation (stringent response) in Bacillus subtilis. Upregulated promoters initiate mostly with ATP and downregulated promoters with GTP. These promoters appear to be sensitive to changes in initiating NTP concentrations. During the stringent response in B. subtilis, when ATP and GTP levels change reciprocally, the identity of the +1 position (A or G) of these promoters is a factor important in their regulation. Mutations that change the identity of position +1 (A for G and vice versa) change the response of the promoter to amino acid starvation. (en)
  • Identifikovali jsme nenáhodné rozložení transkripčních startů (+1A nebo +1G) A-závislých promotorů pro geny, jejichž exprese je buď zvýšena nebo snížena při hladovění po aminokyselinách (tzv. stringentní odpověď) u Bacillus subtilis. Promotory pro geny, jejichž exprese se zvýší, iniciují většinou ATP a promotory pro geny, jejichž exprese se sníží, iniciují GTP. Všechny tyto promotory se jeví jako senzitivní vůči změnám koncentrací iniciačních NTP. V průběhu stringentní odpovědi u B. subtilis, kdy dochází k současné, opačné změně koncentrací ATP a GTP, je identita pozice +1 (A nebo G) těchto promotorů faktorem důležitým pro jejich regulaci. Mutace, které mění identitu této pozice (A za G a naopak) mění i odpověď promotoru na aminokyselinové hladovění. (cs)
Title
  • The identity of the transcription +1 position is crucial for changes in gene expression in response to amino acid starvation in Bacillus subtilis
  • The identity of the transcription +1 position is crucial for changes in gene expression in response to amino acid starvation in Bacillus subtilis (en)
  • Identita transkripční pozice +1 je klíčová pro změny genové exprese při odpovědi na aminokyselinové hladovění u Bacillus subtilis (cs)
skos:prefLabel
  • The identity of the transcription +1 position is crucial for changes in gene expression in response to amino acid starvation in Bacillus subtilis
  • The identity of the transcription +1 position is crucial for changes in gene expression in response to amino acid starvation in Bacillus subtilis (en)
  • Identita transkripční pozice +1 je klíčová pro změny genové exprese při odpovědi na aminokyselinové hladovění u Bacillus subtilis (cs)
skos:notation
  • RIV/68378050:_____/08:00310258!RIV08-AV0-68378050
http://linked.open.../vavai/riv/strany
  • 42;54
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(2B06065), P(GP204/05/P510), Z(AV0Z40550506), Z(AV0Z50200510), Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika
  • 1
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 371331
http://linked.open...ai/riv/idVysledku
  • RIV/68378050:_____/08:00310258
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • RNA polymerase; transcription; start site identity; Bacillus (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [E270C8E36BF0]
http://linked.open...i/riv/nazevZdroje
  • Molecular Microbiology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 69
http://linked.open...iv/tvurceVysledku
  • Krásný, Libor
  • Šanderová, Hana
  • Rejman, Dominik
  • Jonák, Jiří
  • Tišerová, Hana
http://linked.open...n/vavai/riv/zamer
issn
  • 0950-382X
number of pages
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