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Description
| - The main aim of the project is collaboration of top scientific institutions in parasitology and molecular biology, to increase their competitive ability and improve education of young parasitologists. Molecular interactions significant for transmission of pathogen will be studied on the models tick – Borrelia, phlebotomus – Leishmania and trematode – snail. Immune interaction vector – host will be analyzed in the context of pathogen transmission. Analysis of molecular interactions between phlebotomus midgut and surface proteins of Leishmania will elucidate the vector specificity. Genes controlling host susceptibility to the infection with Leishmania and Borrelia will be mapped. Analysis of Trichobilharzia peptidases will clarify the parasite – host compatibility. Immune interactions snail – trematode will be analysed. Lectin and immune interactions with Borrelia spirochetes will be studied in ticks, as well as immunomodulatorty molecules in tick saliva with the aim of development of anti-tick vaccines. Studies on molecular ecology of tick-borne pathogens will contribute to disease prevention. Vaccines based on tick concealed antigens will be developed (en)
- Cílem projektu je podpořit spolupráci špičkových domácích parazitologických a molekulárně biologických pracovišť, zvýšit jejich světovou konkurenceschopnost a zkvalitnit výuku mladých parazitologů. Na modelech klíště - borelie, flebotomus - leishmanie, motolice - plž budou studovány molekulové interakce významné pro přenos patogena vektorem. Imunitní interakce vektora s hostitelem bude analyzována v souvislosti s přenosem patogena. Studium molekulárních interakcí mezi střevem flebotomů a povrchovými proteiny leishmanií objasní specifitu vektorů. Budou zmapovány geny kontrolující vnímavost hostitele k infekci leishmaniemi a boreliemi. Mapování peptidáz u trichobilharzií objasní kompatibilitu parazit – hostitel. Budou analyzovány imunitní interakce trichobilharzií s mezihostitelskými plži. U klíšťat budou studovány lektinové a imunitní interakce s přenášenými boreliemi a imunomodulační molekuly klíštěcích slin s cílem vývoje vakcíny proti klíšťatům a nových léků pro léčbu alergií. Studium molekulární ekologie lymské boreliózy a klíšťové encefalitidy přispěje k jejich prevenci. Budou vyvinuty vakcíny založené na skrytých antigenech klíštěte
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Title
| - Centre for molecular ecology of vectors and pathogens (en)
- Centrum molekulární ekologie vektorů a patogenů
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skos:notation
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http://linked.open...avai/cep/aktivita
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http://linked.open...kovaStatniPodpora
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http://linked.open...ep/celkoveNaklady
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http://linked.open...datumDodatniDoRIV
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http://linked.open...i/cep/druhSouteze
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http://linked.open...ep/duvernostUdaju
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http://linked.open.../cep/fazeProjektu
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http://linked.open...ai/cep/hlavniObor
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http://linked.open...hodnoceniProjektu
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http://linked.open...vai/cep/kategorie
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http://linked.open.../cep/klicovaSlova
| - Molekulární ekologie, klíště, flebotomus, borelie, leishmanie, Trichobilharzia (en)
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http://linked.open...ep/partnetrHlavni
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http://linked.open...inujicichPrijemcu
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http://linked.open...cep/pocetPrijemcu
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http://linked.open...ocetSpoluPrijemcu
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http://linked.open.../pocetVysledkuRIV
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http://linked.open...enychVysledkuVRIV
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http://linked.open...lneniVMinulemRoce
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http://linked.open.../prideleniPodpory
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http://linked.open...iciPoslednihoRoku
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http://linked.open...atUdajeProjZameru
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http://linked.open.../vavai/cep/soutez
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http://linked.open...usZobrazovaneFaze
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http://linked.open...ai/cep/typPojektu
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http://linked.open...ep/ukonceniReseni
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http://linked.open.../cep/vedlejsiObor
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http://linked.open...ep/zahajeniReseni
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http://linked.open...jektu+dodavatelem
| - Molecules of vectors (tick, phlebotomus, snail) and pathogens (Borrelia burgdorferi, tick-borne encephalitis virus, Trichobilharzia) participating in their mutual interactions were identified and characterized. The role of vector saliva in pathogen transmission was elucidated. Molecular basis of hemoglobin digestion in tick midgut was characterized. Anti-tick vaccine was patented. (en)
- Byly identifikovány a charakterizovány molekuly vektorů (klíště, flebotomus, plž) a patogenů (Borrelia burgdorferi, virus klíšťové encefalitidy, Trichobilharzia) podílející se na jejich vzájemných interakcích. Byla objasněna úloha slin vektora při přenosu patogenů. Byla charakterizována molekulární podstata trávení hemoglobinu ve střevě klíšťat. Byla patentována vakcína proti klíšťatům. (cs)
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http://linked.open...tniCyklusProjektu
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http://linked.open.../cep/klicoveSlovo
| - borelie
- flebotomus
- klíště
- leishmanie
- Molekulární ekologie
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is http://linked.open...vavai/riv/projekt
of | - The majority of sialylated glycoproteins in adult Ixodes ricinus ticks originate in the host, not the tick
- Glycobiochemistry of ticks, vectors of infectious diseases: carbohydrate-binding proteins and glycans
- Functional expression and characterization of cathepsin B and L from the gut of the tick Ixodes ricinus
- Penetration of Trichobilharzia cercariae into mammals: dangerous or negligible event?
- Mouse to human comparative genetics reveals a novel immunoglobulin E-controlling locus on Hsa8q12
- Leishmania parasite detection and quantification using PCR-ELISA
- Trypanosoma culicavium sp. nov., an avian trypanosome transmitted by Culex mosquitoes
- Title: Re-Emergence of Visceral and Cutaneous Leishmaniasis in the Greek Island of Crete
- Trichobilharzia regenti: Antigenic structures of intravertebrate stages
- Trichobilharzia
- The Tick Salivary Protein Sialostatin L Inhibits the Th9-Derived Production of the Asthma-Promoting Cytokine IL-9 and Is Effective in the Prevention of Experimental Asthma
- Tick saliva suppresses IFN signalling in dendritic cells upon Borrelia afzelii infection
- Tick saliva-mediated immunomodulation of the vertebrate host
- Lymnaea neotropica and Lymnaea viatrix, potential intermediate hosts for Fascioloides magna
- Profiling of proteolytic enzymes in the gut of the tick Ixodes ricinus reveals an evolutionarily conserved network of aspartic and cysteine peptidases
- Dynamics of digestive proteolytic system during blood feeding of the hard tick Ixodes ricinus
- Specificity of anti-saliva immune response in mice repeatedly bitten by Phlebotomus sergenti
- Distinct genetic control of parasite elimination, dissemination, and disease after Leishmania major infection
- Chromosome 12q24.3 controls sensitization to cat allergen in patients with asthma from Siberia, Russia
- Loci controlling lymphocyte production of interferon gamma after alloantigen stimulation in vitro and their co-localization with genes controlling lymphocyte infiltration of tumors and tumor susceptibility
- Crystallization and diffraction analysis of the serpin IRS-2 from the hard tick Ixodes ricinus
- Cathepsins B1 and B2 in the neuropathogenic schistosome Trichobilharzia regenti: distinct gene expression profiles and presumptive roles throughout the life cycle
- Antibody responses induced by Trichobilharzia regenti antigens in murine and human hosts exhibiting cercarial dermatitis
- The functional expression and characterisation of a cysteine peptidase from the invasive stage of the neuropathogenic schistosome Trichobilharzia regenti
- Sex in Leishmania
- Peritrophic matrix of Phlebotomus duboscqi and its kinetics during Leishmania major development
- Cutaneous leishmaniasis caused by Leishmania infantum transmitted by Phlebotomus tobbi
- Inhibitor of Cysteine Peptidase Does Not Influence the Development of Leishmania mexicana in Lutzomyia longipalpis
- Cercarial dimensions and surface structures as a tool for species determination of Trichobilharzia spp.
- Analysis of salivary transcripts and antigens of the sand fly Phlebotomus arabicus
- In vitro cultivation of early schistosomula of nasal and visceral bird schistosomes (Trichobilharzia spp., Schistosomatidae)
- Peptidases of trematodes
- Hemoglobin digestion in blood-feeding ticks: mapping of multipeptidase pathway by functional proteomics
- The stage-regulated HASPB and SHERP proteins are essential for differentiation of the protozoan parasite Leishmania major in its sand fly vector, Phlebotomus papatasi
- Leishmania major Glycosylation Mutants Require Phosphoglycans (lpg2(-)) but Not Lipophosphoglycan (lpg1(-)) for Survival in Permissive Sand Fly Vectors
- The life cycle and host specificity of Psychodiella sergenti n. sp. and Ps. tobbi n. sp. (Protozoa: Apicomplexa) in sand flies Phlebotomus sergenti and Ph. tobbi (Diptera: Psychodidae)
- Stage-Specific Adhesion of Leishmania Promastigotes to Sand Fly Midguts Assessed Using an Improved Comparative Binding Assay
- Measurement of Recent Exposure to Phlebotomus argentipes, the Vector of Indian Visceral Leishmaniasis, by Using Human Antibody Responses to Sand Fly Saliva
- Methodical approaches in the identification of areas with a potential risk of infection by bird schistosomes causing cercarial dermatitis
- Herpetomonas trimorpha sp. nov. (Trypanosomatidae, Kinetoplastida), a parasite of the biting midge Culicoides truncorum (Ceratopogonidae, Diptera)
- Crystal structure and functional characterization of an immunomodulatory salivary cystatin from the soft tick Ornithodoros moubata
- Probing into the diversity of trypanosomatid flagellates parasitizing insect hosts in South-West China reveals both endemism and global dispersal
- Atick salivary protein targets cathepsin G and chymase and inhibits host inflammation and platelet aggregation
- Experimental Transmission of Leishmania infantum by Two Major Vectors: A Comparison between a Viscerotropic and a Dermotropic Strain
- Functional characterization of two defensin isoforms of the hard tick Ixodes ricinus
- Fibrinogen-related proteins in ixodid ticks
- Functional genomics of tick thioester-containing proteins reveal the ancient origin of the complement system
- Genetic control of resistance to Trypanosoma brucei brucei infection in mice
- Intraspecific variability of natural populations of Phlebotomus sergenti, the main vector of Leishmania tropica
- IrCL1-The haemoglobinolytic cathepsin L of the hard tick, Ixodes ricinus
- Preparation of highly infective Leishmania promastigotes by cultivation on SNB-9 biphasic medium
- Rodents as Sentinels for the Prevalence of Tick-Borne Encephalitis Virus
- Secretory glands in cercaria of the neuropathogenic schistosome Trichobilharzia regenti - ultrastructural characterization, 3-D modelling, volume and pH estimations
- Trichobilharzia regenti: Host immune response in the pathogenesis of neuroinfection in mice
- Trichobilharzia regenti (Digenea Schistosomatidae) Changes of body wall musculature during the development from miracidium to adult worm
- Updates on Borrelia burgdorferi sensu lato complex with respect to public health
- A deep exploration of the transcriptome and %22excretory/secretory%22 proteome of adult Fascioloides magna
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