About: Functional genomics of tick thioester-containing proteins reveal the ancient origin of the complement system

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About: Functional genomics of tick thioester-containing proteins reveal the ancient origin of the complement system Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Parasite survival inside the tick relies on the ability of a pathogen to escape or inhibit tick immune defenses, but the molecular interactions between the tick and its pathogens remain poorly understood. Here we report that tick genomes are unique in that they contain all known classes of the α2-macroglobulin family (α2M-F) proteins: α2-macroglobulin pan-protease inhibitors, C3 complement components, and insect thioester-containing and macroglobulin-related proteins. RNA interference-mediated gene silencing in the hard tick Ixodes ricinus revealed the central role of a C3-like molecule in the phagocytosis of bacteria and specific functions for α2M-F proteins. Assessment of α2M-F functions in a single organism should significantly contribute to the general knowledge on the evolution and function of the complement system. This publication was accomplished in co-operatin with Prof. Jules A. Hoffmann, the Nobel Prize laureate 2011 in Medicine and Physiology (see acknowledgements). Parasite survival inside the tick relies on the ability of a pathogen to escape or inhibit tick immune defenses, but the molecular interactions between the tick and its pathogens remain poorly understood. Here we report that tick genomes are unique in that they contain all known classes of the α2-macroglobulin family (α2M-F) proteins: α2-macroglobulin pan-protease inhibitors, C3 complement components, and insect thioester-containing and macroglobulin-related proteins. RNA interference-mediated gene silencing in the hard tick Ixodes ricinus revealed the central role of a C3-like molecule in the phagocytosis of bacteria and specific functions for α2M-F proteins. Assessment of α2M-F functions in a single organism should significantly contribute to the general knowledge on the evolution and function of the complement system. This publication was accomplished in co-operatin with Prof. Jules A. Hoffmann, the Nobel Prize laureate 2011 in Medicine and Physiology (see acknowledgements). (en)
Title	Functional genomics of tick thioester-containing proteins reveal the ancient origin of the complement system Functional genomics of tick thioester-containing proteins reveal the ancient origin of the complement system (en)
skos:prefLabel	Functional genomics of tick thioester-containing proteins reveal the ancient origin of the complement system Functional genomics of tick thioester-containing proteins reveal the ancient origin of the complement system (en)
skos:notation	RIV/60077344:_____/11:00367199!RIV12-MSM-60077344
http://linked.open...avai/predkladatel	Biologické centrum AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GAP506/10/2136), P(LC06009), Z(AV0Z60220518)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Kopáček, Petr Loosová, Gabriela Grunclová, Lenka Burešová, Veronika Hajdušek, Ondřej Franta, Zdeněk
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	200529
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/11:00367199
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	tick; thioester-containing proteins; complement (en)
http://linked.open.../riv/klicoveSlovo	tick complement thioester-containing proteins
http://linked.open...odStatuVydavatele	CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV	[AD5119B6554E]
http://linked.open...i/riv/nazevZdroje	Journal of Innate Immunity
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Centre for molecular ecology of vectors and pathogens Functional genomics of the complement-like molecules in the tick Ixodes ricinus
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	3
http://linked.open...iv/tvurceVysledku	Kopáček, Petr Burešová, Veronika Franta, Zdeněk Grunclová, Lenka Hajdušek, Ondřej Levashina, E. A. Loosová, Gabriela
http://linked.open...ain/vavai/riv/wos	000296368900010
http://linked.open...n/vavai/riv/zamer	Parazitismus a parazito-hostitelské vztahy na organismální, buněčné a molekulové úrovni
issn	1662-811X
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1159/000328851
is http://linked.open...avai/riv/vysledek of	Functional genomics of tick thioester-containing proteins reveal the ancient origin of the complement system

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