About: IrCL1-The haemoglobinolytic cathepsin L of the hard tick, Ixodes ricinus

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Blood digestion in the tick gut is based on a multienzyme network comprising acidic peptidases of cysteine and aspartic class. In this work, we provided the detailed biochemical and functional characterization of the cathepsin L named IrCL1 which is involved in the early stage of hemoglobin digestion. Our results suggest that IrCL1 is a promising candidate for development a potential anti-tick vaccine. The article impact was emphasized by the cover page image of the IJP issue. Blood digestion in the tick gut is based on a multienzyme network comprising acidic peptidases of cysteine and aspartic class. In this work, we provided the detailed biochemical and functional characterization of the cathepsin L named IrCL1 which is involved in the early stage of hemoglobin digestion. Our results suggest that IrCL1 is a promising candidate for development a potential anti-tick vaccine. The article impact was emphasized by the cover page image of the IJP issue. (en)
Title	IrCL1-The haemoglobinolytic cathepsin L of the hard tick, Ixodes ricinus IrCL1-The haemoglobinolytic cathepsin L of the hard tick, Ixodes ricinus (en)
skos:prefLabel	IrCL1-The haemoglobinolytic cathepsin L of the hard tick, Ixodes ricinus IrCL1-The haemoglobinolytic cathepsin L of the hard tick, Ixodes ricinus (en)
skos:notation	RIV/60077344:_____/11:00367385!RIV12-MSM-60077344
http://linked.open...avai/predkladatel	Biologické centrum AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GAP207/10/2183), P(GPP502/11/P682), P(IAA600960910), P(LC06009), Z(AV0Z40550506), Z(AV0Z60220518)
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Kopáček, Petr Dvořák, Jan Sojka, Daniel Franta, Zdeněk Frantová, Helena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	205839
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/11:00367385
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	tick gut; hemoglobin digestion; cathepsin L (en)
http://linked.open.../riv/klicoveSlovo	cathepsin L hemoglobin digestion tick gut
http://linked.open...odStatuVydavatele	AU - Australské společenství
http://linked.open...ontrolniKodProRIV	[AC72A5A1779E]
http://linked.open...i/riv/nazevZdroje	International Journal for Parasitology
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	13 (xsd:int)
http://linked.open...vavai/riv/projekt	Structural proteomics of proteolytic systems in ticks Centre for molecular ecology of vectors and pathogens Mediated endocytosis of host hemoglobin in tick gut cells The digestive system of ticks - the target for rational development of vaccine against ticks and tick-borne pathogens
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	41
http://linked.open...iv/tvurceVysledku	Dvořák, Jan Horn, Martin Kopáček, Petr Mareš, Michael Schneider, E. Sojka, Daniel Franta, Zdeněk Caffrey, C. R. Craik, C. S. Frantová, Helena McKerrow, J. H. Srba, Jindřich Talacko, Pavel
http://linked.open...ain/vavai/riv/wos	000296110300005
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství Parazitismus a parazito-hostitelské vztahy na organismální, buněčné a molekulové úrovni
issn	0020-7519
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.ijpara.2011.06.006
is http://linked.open...avai/riv/vysledek of	IrCL1-The haemoglobinolytic cathepsin L of the hard tick, Ixodes ricinus

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