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| Description
| - The project forms a part of the long-term research mission which is to use the knowledge gained from basic science investigations to discover and/or improve therapeutic and plant protection strategies. Emphasizing integrated interdisciplinary approaches to the study of biomolecular structure and function, the scientific activities evolve around the following four themes: 1) chemistry of biologically important molecules relevant to life-threatening diseases, 2) chemistry of infochemicals relevant to the system plant-insect-microorganism, 3) synthetic approaches to biologically active and bioinspired functional materials, and 4) physico-chemical methods, spectroscopy, and molecular modeling aimed at understanding the mechanism of action of target molecules. The project has two major objectives: 1) to foster interdisciplinary research that integrates chemistry, biochemistry and biology with medical and ecological science, and 2) to train students in interdisciplinary research techniques. (en)
- Záměr je součástí dlouhodobého výzkumného programu, jehož cílem je využívání výsledků základního výzkumu při vytváření nových nebo zdokonalování současných terapeutických strategií nebo strategií ochrany rostlin. S důrazem na vertikálně integrované přístupy ke studiu biomolekulárních struktur a funkcí se výzkumná činnost orientuje na čtyři tématické okruhy: (1) chemie biologicky důležitých molekul týkajících se závažných onemocnění, (2) chemie infochemikálií významných pro systém rostlina-hmyz-mikroorganismus, (3) syntetické přístupy k biologicky aktivním a funkčním materiálům, a (4) fyzikálně chemické metody, spektroskopie a molekulární modelování zaměřené na poznání mechanizmu účinku cílových molekul. Projekt má dva hlavní cíle: (1) podporovat interdisciplinární výzkum integrující chemii, biochemii a biologii s lékařskými a ekologickými vědami a (2) školit studenty v interdisciplinárních metodikách výzkumu.
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| Title
| - Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství
- Regulation of Life Processes: Chemical Modulators of Selected Biological Systems Relevant to Medicine and Agriculture (en)
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| http://linked.open...kovaStatniPodpora
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| http://linked.open...ez/celkoveNaklady
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| http://linked.open...datumDodatniDoRIV
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| http://linked.open...vavai/cez/dodavka
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| http://linked.open...ez/duvernostUdaju
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| http://linked.open...in/vavai/cez/faze
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| http://linked.open...ai/cez/hlavniObor
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| http://linked.open...vai/cez/hodnoceni
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| http://linked.open.../cez/kategorieVaV
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| http://linked.open.../cez/klicovaSlova
| - interdisciplinary; medicinal chemistry; chemical ecology; molecular modeling; supramolecular structures; bioactive compounds; hormones; analogs; antiviral drugs; anticancer drugs; semiochemicals; insect control; plant growth; transition metals (en)
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| http://linked.open...cez/partnerHlavni
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| http://linked.open...z/poceVysledkuRIV
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| http://linked.open...inujicichPrijemcu
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| http://linked.open...cez/pocetPrijemcu
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| http://linked.open...ocetSpoluPrijemcu
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| http://linked.open...enychVysledkuVRIV
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| http://linked.open...lneniVMinulemRoce
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| http://linked.open.../prideleniPodpory
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| http://linked.open.../vavai/cez/resort
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| http://linked.open...iciPoslednihoRoku
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| http://linked.open...atUdajeProjZameru
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| http://linked.open...usZobrazovaneFaze
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| http://linked.open...ez/ukonceniReseni
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| http://linked.open.../cez/vedlejsiObor
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| http://linked.open...ez/zahajeniReseni
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| http://linked.open...n/vavai/cez/zamer
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| http://linked.open...sledkuDodavatelem
| - Originální metodologie zahrnující design vhodných strukturních motivů, syntézu biologicky aktivních a funkčních materiálů a molekulární modelování interakcí v bimolekulárních komplexech byly využity k vývoji nových typů sloučenin s cytostatickou, antivirální či imunomodulační aktivitou. Nové poznatky jsou potenciálně využitelné v diagnostice a prevenci nemocí. (cs)
- Original methodologies including the design of appropriate structural motifs, synthesis of biologically active and functional materials and molecular modeling of interactions in biomolecular complexes were exploited to develop new types of compounds with cytostatic, antiviral and/or immunomodulating activity. The new findings are potentially applicable in diagnostics and human medicine. (en)
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| http://linked.open...cez/zivotniCyklus
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| is http://linked.open...n/vavai/riv/zamer
of | - In vitro inhibitory effects of thymol and quinones of Nigella sativa seeds on cyclooxygenase-1 and -2 catalyzed prostaglandin E2 biosyntheses.
- Exploitation of kairomones and synomones by Medetera spp. (Diptera: Dolichopodidae), predators of spruce bark beetles
- MSB 2010. 25 th International Symposium on Microscale BioSeparations
- Functional expression and characterization of cathepsin B and L from the gut of the tick Ixodes ricinus
- Ultrastructure of the Digestive Tract in Acarus siro (Acari: Acaridida)
- Chitin in the peritrophic membrane of Acarus siro (Acari: Acaridae) as a target for novel Acaricides
- Unusual Fatty Acids in the Fat Body of the Early Nesting Bumblebee, Bombus pratorum
- Age-dependent changes in structure and function of the male labial gland in Bombus terrestris
- The impact of altered polyprotein ratios on the assembly and infectivity of Mason-Pfizer monkey virus.
- Biodegradation of PAHs in long-term contaminated soil cultivated with european white birch (betula pendula) and red mulberry (morus rubra) tree
- Cloning the bacterial bphC gene into Nicotiana tabacum to improve the efficiency of PCB phytoremediation
- Bacterial degradation of polychlorinated biphenyls
- Approaches to microbial diversity analysis in contaminated environments
- Absorption and translocation of polybrominated diphenyl ethers (PBDEs) by plants from contaminated sewage sludge.
- Modified approach for preparing (E)-stilbenes related to resveratrol and evaluation of their potencial immunobiologal effect
- Regioisomeric Analysis of Triacylglycerols Using Silver-ion Liquid Chromatography-Atmospheric Pressure Chemical Ionization Mass Spectrometry: Comparison of Five Different Mass Analyzers
- Nádorové markery u karcinomu prostaty, blýská se na lepší časy
- Sesquiterpene lactone trilobolide activates production of interferon- gamma and nitric oxide
- Preparation of steroid sulfamates and their interaction with GABAA receptor
- Allopregnanolone (3α-hydroxy-5α-pregnan-20-one) derivatives with a polar chain in position 16α: synthesis and activity
- Towards a better understanding of the specificity of protein-protein interaction
- Transforming Anion Instability into Stability: Contrasting Photoionization of Three Protonation Forms of the Phosphate Ion upon Moving into Water
- Transferability of Various Molecular Property Tensors in Vibrational Spectroscopy
- Theoretical calculations of physico-chemical and spectroscopic properties of bioinorganic systems: current limits and perspectives
- Transition-Metal-Mediated or -Catalyzed Syntheses of Steroids and Steroid-Like Compounds
- Theoretical Modeling of the Surface-Enhanced Raman Optical Activity
- Three Types of Induced Tryptophan Optical Activity Compared in Model Dipeptides: Theory and Experiment
- Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells
- 4-(1-Haloalkyl)-3-nitrotetrahydrofurans as versatile scaffolds for the synthesis of diversely functionalized tetrahydrofurans
- Process for preparing substituted 3- and 4-(pentafluorosulfanyl)benzenes
- 13C GIAO DFT calculation as a tool for configuration prediction of N-O group in saturated heterocyclic N-oxides
- [11]Anthrahelicene on TiO2 surfaces
- 2,3,4,5-Tetraphenylbiphenyl-Containing CuI/ReI Complexes: Synthesis, Property Analysis and Theoretical Studies
- Způsob výroby substituovaných diamidů fosfonových kyselin
- Method of testing inhibitors of virus particle formation in large extent by making use of labeled oligonucleotides or nucleic acids
- The method for the labeling of double-stranded DNA molecules
- The method for the revelation of specific pyrimidine nucleosides in the structure of the double-stranded DNA for the reaction with the antibodies that react with these nucleosides
- Způsob eliminace antigenních vlastností 5-etynyl-2´-deoxyuridinu a5-etynyluridinu při detekci nukleových kyselin
- Deriváty insulinu s cyklickou strukturou v C-konci B-řetězce
- Crystallization of the Effector-Binding Domain of Repressor DeoR from Bacillus subtilis
- Lipopolyaminy sperminového typu pro konstrukci liposomálních transfekčních systémů
- Lipophosphonoxins, method of their preparation and use
- NMR, FTIR and DFT study of the interaction of the benzoate anion with meso-octamethylcalix[4]pyrrole
- DNA conformations and their sequence preferences
- Geometrical and electronic structure variability of the sugar-phosphate backbone in nucleic acids
- General Base Catalysis for Cleavage by the Active-Site Cytosine of the Hepatitis Delta Virus Ribozyme: QM/MM Calculations Establish Chemical Feasibility
- Balance of Attraction and Repulsion in Nucleic-Acid Base Stacking: CCSD(T)/Complete-Basis-Set-Limit Calculations on Uracil Dimer and a Comparison with the Force-Field Description
- Flavin?cyclodextrin conjugates as catalysts of enantioselective sulfoxidations with hydrogen peroxide in aqueous media
- Synthesis of 2-(perfluoroalkyl)ethyl potassium sulfates based on perfluorinated Grignard reagents
- Helquats: A Facile, Modular, Scalable Route to Novel Helical Dications
- Tight beta-turns in peptides. DFT-based study of infrared absorption and vibrational circular dichroism for various conformers including solvent effects
- Response to comment on autoionization at the surface of neat water: is the top layer pH neutral, basic or acidic?
- Syntheses of N3-substituted thymine acyclic nucleoside phosphonates and a comparison of their inhibitory effect towards thymidine phosphorylase
- Recent developments in CE and CEC of peptides
- Determination of binding constants of valinomycin complexes with ammonium and alkali metal ions by capillary affinity electrophoresis
- Additional minor ecdysteroid components of Leuzea carthamoides
- Alpha anomer of 5-aza-2'-deoxycytidine down-regulates hTERT mRNA expression in human leukemia HL-60 cells
- Semiochemicals related to the aphid Cinara pilicornis and its host, Picea abies. A method to assign nepetalactone diastereomers
- Synthesis, cytostatic and anti-HCV activity of 6-(N-substituted aminomethyl)-, 6-(O-substituted hydroxymethyl)- and 6-(S-substituted sulfanylmethyl)purine nucleosides
- Synthesis, cytostatic and antiviral activity of novel 6-[2-(dialkylamino)ethyl]-, 6-(2-alkoxyethyl)-, 6-[2-(alkylsulfanyl)ethyl]- and 6-[2-(dialkylamino)vinyl]purine nucleosides
- Hydroxymethylations of aryl halides by Pd-catalyzed cross-couplings with (benzoyloxy)methylzinc iodide - the scope and limitations of the reaction
- Aminophenyl- and nitrophenyl-labeled nucleoside triphosphates. Synthesis, enzymatic incorporation and electrochemical detection
- A Modular Methodology for the Synthesis of 4- and 3- Substituted Benzene and Aniline C-Ribonucleosides
- A beta-Amino acid Pyrokinin Analog Induces Irregular Pupariation Behavior in Larvae of the Flesh Fly Sarcophaga bullata
- Diapause hormone in the corn earworm, Helicoverpa zea: Optimum temperature for activity, structure–activity relationships, and efficacy in accelerating flesh fly pupariation
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