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| rdf:type
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| Description
| - Dithymoquinone, thymohydroquinone, thymol and thymoquinone, the compounds derived from N. sativa seeds, were investigated for their in vitro anti-inflammatory activities using cyclooxygenase-1 (COX-1) and-2 (COX-2) assays. Our results show that all substances tested possessed significant inhibitory activity against at least one COX form at the concentrations comparable with indomethacin. Thymol was the most active against COX-1 with IC50 value of 0.2 uM, while thymohydroquinone and thymoquinone exhibited the strongest inhibitory effect on COX-2 with IC50 values of 0.1 and 0.3 uM, respectively. Moreover, dithymoquinone and thymoquinone showed certain degrees of COX-2 selective inhibition. We conclude that dithymoquinone, thymohydroquinone, thymol and thymoquinone can participate in general anti-inflammatory activity of N. sativa and suggest that these agents should be further studied for possible use as non-steroidal anti-inflammatory drugs.
- Dithymoquinone, thymohydroquinone, thymol and thymoquinone, the compounds derived from N. sativa seeds, were investigated for their in vitro anti-inflammatory activities using cyclooxygenase-1 (COX-1) and-2 (COX-2) assays. Our results show that all substances tested possessed significant inhibitory activity against at least one COX form at the concentrations comparable with indomethacin. Thymol was the most active against COX-1 with IC50 value of 0.2 uM, while thymohydroquinone and thymoquinone exhibited the strongest inhibitory effect on COX-2 with IC50 values of 0.1 and 0.3 uM, respectively. Moreover, dithymoquinone and thymoquinone showed certain degrees of COX-2 selective inhibition. We conclude that dithymoquinone, thymohydroquinone, thymol and thymoquinone can participate in general anti-inflammatory activity of N. sativa and suggest that these agents should be further studied for possible use as non-steroidal anti-inflammatory drugs. (en)
- Dithymoquinone, thymohydroquinone, thymol and thymoquinone, the compounds derived from N. sativa seeds, were investigated for their in vitro anti-inflammatory activities using cyclooxygenase-1 (COX-1) and-2 (COX-2) assays. Our results show that all substances tested possessed significant inhibitory activity against at least one COX form at the concentrations comparable with indomethacin. Thymol was the most active against COX-1 with IC50 value of 0.2 uM, while thymohydroquinone and thymoquinone exhibited the strongest inhibitory effect on COX-2 with IC50 values of 0.1 and 0.3 uM, respectively. Moreover, dithymoquinone and thymoquinone showed certain degrees of COX-2 selective inhibition. We conclude that dithymoquinone, thymohydroquinone, thymol and thymoquinone can participate in general anti-inflammatory activity of N. sativa and suggest that these agents should be further studied for possible use as non-steroidal anti-inflammatory drugs. (cs)
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| Title
| - In vitro inhibitory effects of thymol and quinones of Nigella sativa seeds on cyclooxygenase-1 and -2 catalyzed prostaglandin E2 biosyntheses.
- In vitro inhibitory effects of thymol and quinones of Nigella sativa seeds on cyclooxygenase-1 and -2 catalyzed prostaglandin E2 biosyntheses. (en)
- In vitro inhibiční efekt thymolu a chinonů ze semen Nigella sativa na biosyntézu prostaglandínu E2 prostřednictvím COX-1 a -2. (cs)
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| skos:prefLabel
| - In vitro inhibitory effects of thymol and quinones of Nigella sativa seeds on cyclooxygenase-1 and -2 catalyzed prostaglandin E2 biosyntheses.
- In vitro inhibitory effects of thymol and quinones of Nigella sativa seeds on cyclooxygenase-1 and -2 catalyzed prostaglandin E2 biosyntheses. (en)
- In vitro inhibiční efekt thymolu a chinonů ze semen Nigella sativa na biosyntézu prostaglandínu E2 prostřednictvím COX-1 a -2. (cs)
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| skos:notation
| - RIV/60460709:41610/05:13528!RIV06-GA0-41610___
|
| http://linked.open.../vavai/riv/strany
| |
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - P(1P04OC926.001), P(GA525/02/0257), Z(AV0Z40550506)
|
| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/60460709:41610/05:13528
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| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - Nigella sativa, thymol, thymoquinone, cyclooxygenase-1, cyclooxygenase-2, anti-inflammatory activity (en)
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| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - DE - Spolková republika Německo
|
| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| |
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Kokoška, Ladislav
- Maršík, Petr
- Vaněk, Tomáš
- Landa, Přemysl
- Soudek, Petr
- Nepovím, Aleš
|
| http://linked.open...n/vavai/riv/zamer
| |
| issn
| |
| number of pages
| |
| http://localhost/t...ganizacniJednotka
| |
| is http://linked.open...avai/riv/vysledek
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