About: Alpha anomer of 5-aza-2'-deoxycytidine down-regulates hTERT mRNA expression in human leukemia HL-60 cells

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About: Alpha anomer of 5-aza-2'-deoxycytidine down-regulates hTERT mRNA expression in human leukemia HL-60 cells Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	DNA methylation inhibitors are being extensively studied as potential anticancer agents. In the present study, we compared the capability of alpha anomer of 5-aza-2'-deoxycytidine(alpha-5-azadCyd) to induce down-regulation of hTERT expression in HL-60 cells with other nucleoside analogs that act as DNA methylation inhibitors: beta-5-azadCyd (decitabine), (S)-9-(2,3-dihydroxypropyl)adenine [(S)-DHPA], isobutyl ester of (R,S)-3-(adenin-9-yl)-2-hydroxypropanoic acid [(R,S)-AHPA-ibu] and prospective DNA methylation inhibitors (S)-1-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine [(S)-HPMPazaC] and 5-fluoro-zebularine (F-PymRf). DNA methylation inhibitors are being extensively studied as potential anticancer agents. In the present study, we compared the capability of alpha anomer of 5-aza-2'-deoxycytidine(alpha-5-azadCyd) to induce down-regulation of hTERT expression in HL-60 cells with other nucleoside analogs that act as DNA methylation inhibitors: beta-5-azadCyd (decitabine), (S)-9-(2,3-dihydroxypropyl)adenine [(S)-DHPA], isobutyl ester of (R,S)-3-(adenin-9-yl)-2-hydroxypropanoic acid [(R,S)-AHPA-ibu] and prospective DNA methylation inhibitors (S)-1-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine [(S)-HPMPazaC] and 5-fluoro-zebularine (F-PymRf). (en) Inhibitory DNA metylace jsou studovány jako slibná protinádorová léčiva. V této práci srovnáváme schopnost alfa anomeru 5-aza-2'-deoxycytidinu(alfa-5-azadCyd) potlačit expresi telomerázy, enzymu, jehož zvýšená exprese je prokazatelná až u 90 % maligních nádorů, s ostatními analogy nukleosidů majícími hypometylační účinky: beta-5-azadCyd (decitabin), (S)-9-(2,3-dihydroxypropyl)adenin [(S)-DHPA], izobutyl ester (R,S)-3-(adenin-9-yl)-2-hydroxypropanové kyseliny [(R,S)-AHPA-ibu] a perspektivních inhibitorů DNA metylace (S)-1-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosinu [(S)-HPMPazaC] and 5-fluoro-zebularinu (F-PymRf). (cs)
Title	Alpha anomer of 5-aza-2'-deoxycytidine down-regulates hTERT mRNA expression in human leukemia HL-60 cells Alpha anomer of 5-aza-2'-deoxycytidine down-regulates hTERT mRNA expression in human leukemia HL-60 cells (en) Alfa anomer 5-aza-2'-deoxycytidinu snižuje expresi hTERT mRNA expression v lidských leukemických buňkách HL-60 (cs)
skos:prefLabel	Alpha anomer of 5-aza-2'-deoxycytidine down-regulates hTERT mRNA expression in human leukemia HL-60 cells Alpha anomer of 5-aza-2'-deoxycytidine down-regulates hTERT mRNA expression in human leukemia HL-60 cells (en) Alfa anomer 5-aza-2'-deoxycytidinu snižuje expresi hTERT mRNA expression v lidských leukemických buňkách HL-60 (cs)
skos:notation	RIV/61388963:_____/08:00305805!RIV08-AV0-61388963
http://linked.open.../vavai/riv/strany	965;972
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0508), P(1QS400550501), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Votruba, Ivan Hájek, Miroslav Krečmerová, Marcela Holý, Antonín Tloušťová, Eva
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	355460
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/08:00305805
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	alpha-5-aza-2'-deoxycytidine; DNA hypomethylation; hTERT; c-myc (en)
http://linked.open.../riv/klicoveSlovo	c-myc DNA hypomethylation alpha-5-aza-2'-deoxycytidine hTERT
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[32B526622A2D]
http://linked.open...i/riv/nazevZdroje	Biochemical Pharmacology
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	New Antivirals and Antineoplastics Novel antivirals and antineoplastics
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	75
http://linked.open...iv/tvurceVysledku	Holý, Antonín Krečmerová, Marcela Votruba, Ivan Tloušťová, Eva Hájek, Miroslav
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství
issn	0006-2952
number of pages	8 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Alpha anomer of 5-aza-2'-deoxycytidine down-regulates hTERT mRNA expression in human leukemia HL-60 cells Alpha anomer of 5-aza-2'-deoxycytidine down-regulates hTERT mRNA expression in human leukemia HL-60 cells Alpha anomer of 5-aza-2'-deoxycytidine down-regulates hTERT mRNA expression in human leukemia HL-60 cells Alpha anomer of 5-aza-2'-deoxycytidine down-regulates hTERT mRNA expression in human leukemia HL-60 cells

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