About: Functional characterization of two defensin isoforms of the hard tick Ixodes ricinus

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About: Functional characterization of two defensin isoforms of the hard tick Ixodes ricinus Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The immune system of ticks is stimulated to produce many pharmacologically active molecules during feeding and especially during pathogen invasion. Defensins represent a specific group of antimicrobial compounds with 6 conserved cysteine residues. Two isoforms of the defensin gene (def1 and def2) were identified in the European tick Ixodes ricinus. Expression of both genes was induced in different tick organs by a blood feeding or pathogen injection. Synthetic peptides def1 and def2 were shown to have antimicrobial activitiy against Gram+ bacteria, while Gram- bacteria, yeast, Tick Borne Encephalitis and West Nile Viruses were shown to be insensitive. In addition to antimicrobial activities, the hemolysis effect of def1 and def2 on human erythrocytes was also established. Defensins may play an important role in defence against different pathogens. Moreover this is a first report of a one amino acid substitution in a defensins molecule and its impact on antimicrobial activity. The immune system of ticks is stimulated to produce many pharmacologically active molecules during feeding and especially during pathogen invasion. Defensins represent a specific group of antimicrobial compounds with 6 conserved cysteine residues. Two isoforms of the defensin gene (def1 and def2) were identified in the European tick Ixodes ricinus. Expression of both genes was induced in different tick organs by a blood feeding or pathogen injection. Synthetic peptides def1 and def2 were shown to have antimicrobial activitiy against Gram+ bacteria, while Gram- bacteria, yeast, Tick Borne Encephalitis and West Nile Viruses were shown to be insensitive. In addition to antimicrobial activities, the hemolysis effect of def1 and def2 on human erythrocytes was also established. Defensins may play an important role in defence against different pathogens. Moreover this is a first report of a one amino acid substitution in a defensins molecule and its impact on antimicrobial activity. (en)
Title	Functional characterization of two defensin isoforms of the hard tick Ixodes ricinus Functional characterization of two defensin isoforms of the hard tick Ixodes ricinus (en)
skos:prefLabel	Functional characterization of two defensin isoforms of the hard tick Ixodes ricinus Functional characterization of two defensin isoforms of the hard tick Ixodes ricinus (en)
skos:notation	RIV/60077344:_____/11:00360134!RIV12-MSM-60077344
http://linked.open...avai/predkladatel	Biologické centrum AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA206/09/1782), P(GAP302/11/1901), P(GD206/09/H026), P(LC06009), Z(AV0Z40550506), Z(AV0Z60220518), Z(MSM6007665801)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Grubhoffer, Libor Růžek, Daniel Rudenko, Natalia Chrudimská, Tereza
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	200524
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/11:00360134
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	defensin; antimicrobial compounds; Ixodes ricinus (en)
http://linked.open.../riv/klicoveSlovo	Ixodes ricinus antimicrobial compounds defensin
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[F440ED5BEDEF]
http://linked.open...i/riv/nazevZdroje	Parasites Vectors
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Centre for molecular ecology of vectors and pathogens Antimikrobiální proteiny v imunitním systému kompetentních a nekompetentních vektorů spirochét Borrelia burgdorferi: hledání boréliacidního faktoru. Parasite-host relationships and the evolution of parasitism Interaction of Lyme borreliosis spirochetes and salivary glands of Ixodes ricinus tick: the role of borrelia OspC protein.
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	4
http://linked.open...iv/tvurceVysledku	Grubhoffer, Libor Rudenko, Natalia Růžek, Daniel Slaninová, Jiřina Chrudimská, Tereza
http://linked.open...ain/vavai/riv/wos	000291094400001
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství Parazitismus a parazito-hostitelské vztahy na organismální, buněčné a molekulové úrovni EKOLOGICKÉ, EVOLUČNÍ A EXPERIMENTÁLNĚ BIOLOGICKÉ PŘÍSTUPY KE STUDIU VZNIKU A VÝZNAMU BIODIVERZITY
issn	1756-3305
number of pages	9 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Functional characterization of two defensin isoforms of the hard tick Ixodes ricinus

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