About: Glycobiochemistry of ticks, vectors of infectious diseases: carbohydrate-binding proteins and glycans

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The lectin IxoA and enzyme chitinase 1 are potential factors of innate immunity in I. ricinus, especially active against bacterial and fungal infections. We succesfully knock-down the genes for both IxoA and Chix1 by RNA inhibition. Hemolymph of IxoA knock-down ticks totally lost its hemagglutination activity and the function of both genes is further studied by RNAi. Glycoproteins and sialic acid (SA) in salivary glands (SG) of the tick Ixodes ricinus: SG in ticks are of fundamental significance for the pathogen transmission to the host, amongst others. We mapped the glycoproteins of tick SG, potential receptors for the transmitted pathogens. We identified SA in glycoproteome of SG as well as a protein binding this carbohydrate. Based on the molecular features of the protein, it is similar to mouse sialoadhesin Siglec-1. The lectin IxoA and enzyme chitinase 1 are potential factors of innate immunity in I. ricinus, especially active against bacterial and fungal infections. We succesfully knock-down the genes for both IxoA and Chix1 by RNA inhibition. Hemolymph of IxoA knock-down ticks totally lost its hemagglutination activity and the function of both genes is further studied by RNAi. Glycoproteins and sialic acid (SA) in salivary glands (SG) of the tick Ixodes ricinus: SG in ticks are of fundamental significance for the pathogen transmission to the host, amongst others. We mapped the glycoproteins of tick SG, potential receptors for the transmitted pathogens. We identified SA in glycoproteome of SG as well as a protein binding this carbohydrate. Based on the molecular features of the protein, it is similar to mouse sialoadhesin Siglec-1. (en)
Title	Glycobiochemistry of ticks, vectors of infectious diseases: carbohydrate-binding proteins and glycans Glycobiochemistry of ticks, vectors of infectious diseases: carbohydrate-binding proteins and glycans (en)
skos:prefLabel	Glycobiochemistry of ticks, vectors of infectious diseases: carbohydrate-binding proteins and glycans Glycobiochemistry of ticks, vectors of infectious diseases: carbohydrate-binding proteins and glycans (en)
skos:notation	RIV/60077344:_____/09:00336484!RIV10-MSM-60077344
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(LC06009), Z(AV0Z60220518)
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Grubhoffer, Libor Rudenko, Natalia Vancová, Marie Hajdušek, Ondřej Štěrba, Ján
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	316525
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/09:00336484
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Carbohydrate-binding molecules; Ixodes ricinus; knock-down (en)
http://linked.open.../riv/klicoveSlovo	Carbohydrate-binding molecules knock-down Ixodes ricinus
http://linked.open...ontrolniKodProRIV	[97E8A39273A0]
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Centre for molecular ecology of vectors and pathogens
http://linked.open...UplatneniVysledku	2009
http://linked.open...iv/tvurceVysledku	Grubhoffer, Libor Rudenko, Natalia Vancová, Marie Hajdušek, Ondřej Štěrba, Ján
http://linked.open...n/vavai/riv/zamer	Parazitismus a parazito-hostitelské vztahy na organismální, buněčné a molekulové úrovni

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