About: Specificity of anti-saliva immune response in mice repeatedly bitten by Phlebotomus sergenti

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About: Specificity of anti-saliva immune response in mice repeatedly bitten by Phlebotomus sergenti Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Sand flies transmit parasites of genus Leishmania, the causative agents of leishmaniases. Experimental hosts repeatedly exposed to sand fly saliva can control Leishmania infection. Cell-mediated anti-saliva immune response is most likely responsible for this protective effect; however, there is no study concerning its antigenic specificity. In this study, splenocytes from mice exposed to Phlebotomus sergenti bites were challenged ex vivo with saliva from three different sand flies. Mice bitten by P. sergenti had higher proliferation to homologous antigen than splenocytes from naive mice. Splenocytes from P. sergenti bitten mice as well as anti-P. sergenti antibodies partially cross-reacted with P. papatasi saliva. In contrast, no crossreactivity was found with P. arabicus saliva. Our data indicate that both cellular and humoral immunity react in a species-specific manner and the unique transmission-blocking vaccine would be required for each vector – Leishmania combination. Sand flies transmit parasites of genus Leishmania, the causative agents of leishmaniases. Experimental hosts repeatedly exposed to sand fly saliva can control Leishmania infection. Cell-mediated anti-saliva immune response is most likely responsible for this protective effect; however, there is no study concerning its antigenic specificity. In this study, splenocytes from mice exposed to Phlebotomus sergenti bites were challenged ex vivo with saliva from three different sand flies. Mice bitten by P. sergenti had higher proliferation to homologous antigen than splenocytes from naive mice. Splenocytes from P. sergenti bitten mice as well as anti-P. sergenti antibodies partially cross-reacted with P. papatasi saliva. In contrast, no crossreactivity was found with P. arabicus saliva. Our data indicate that both cellular and humoral immunity react in a species-specific manner and the unique transmission-blocking vaccine would be required for each vector – Leishmania combination. (en)
Title	Specificity of anti-saliva immune response in mice repeatedly bitten by Phlebotomus sergenti Specificity of anti-saliva immune response in mice repeatedly bitten by Phlebotomus sergenti (en)
skos:prefLabel	Specificity of anti-saliva immune response in mice repeatedly bitten by Phlebotomus sergenti Specificity of anti-saliva immune response in mice repeatedly bitten by Phlebotomus sergenti (en)
skos:notation	RIV/68378050:_____/09:00334103!RIV10-MSM-68378050
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GP206/06/P015), P(LC06009), Z(AV0Z50520514), Z(MSM0021620828)
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Rohoušová, Iva Lipoldová, Marie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	342825
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/09:00334103
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	anti-saliva IgG; cellular response; Phlebotomus sergenti (en)
http://linked.open.../riv/klicoveSlovo	Phlebotomus sergenti cellular response anti-saliva IgG
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[804463271406]
http://linked.open...i/riv/nazevZdroje	Parasite immunology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Centre for molecular ecology of vectors and pathogens Immunomodulation activity in sand fly saliva (Diptera: Phlebotominae)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	31
http://linked.open...iv/tvurceVysledku	Rohoušová, Iva Volf, P. Lipoldová, Marie Drahota, J.
http://linked.open...ain/vavai/riv/wos	000271469600005
http://linked.open...n/vavai/riv/zamer	Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů Ekologické procesy v evoluci modelových skupin organismů
issn	0141-9838
number of pages	5 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Specificity of anti-saliva immune response in mice repeatedly bitten by Phlebotomus sergenti Specificity of anti-saliva immune response in mice repeatedly bitten by Phlebotomus sergenti Specificity of anti-saliva immune response in mice repeatedly bitten by Phlebotomus sergenti Specificity of anti-saliva immune response in mice repeatedly bitten by Phlebotomus sergenti

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