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Description
  • Fibrinogen-related proteins with lectin activity are believed to be part of the tick innate immune system. Some of them were detected in high abundance in the haemolymph of ixodid ticks Dermacentor marginatus, Rhipicephalus appendiculatus, R. pulchellus, and R. sanguineus. These proteins were recognised by sera directed against the tick lectin Dorin M and the haemagglutination activity of the ticks R. appendiculatus and D. marginatus. The fibrinogen-related proteins were shown to be glycosylated and they were localised in salivary glands, midguts, and haemocytes of D. marginatus. The detected proteins have potential as targets for anti-tick vaccines and as antimicrobial proteins in pharmacology.
  • Fibrinogen-related proteins with lectin activity are believed to be part of the tick innate immune system. Some of them were detected in high abundance in the haemolymph of ixodid ticks Dermacentor marginatus, Rhipicephalus appendiculatus, R. pulchellus, and R. sanguineus. These proteins were recognised by sera directed against the tick lectin Dorin M and the haemagglutination activity of the ticks R. appendiculatus and D. marginatus. The fibrinogen-related proteins were shown to be glycosylated and they were localised in salivary glands, midguts, and haemocytes of D. marginatus. The detected proteins have potential as targets for anti-tick vaccines and as antimicrobial proteins in pharmacology. (en)
Title
  • Fibrinogen-related proteins in ixodid ticks
  • Fibrinogen-related proteins in ixodid ticks (en)
skos:prefLabel
  • Fibrinogen-related proteins in ixodid ticks
  • Fibrinogen-related proteins in ixodid ticks (en)
skos:notation
  • RIV/60077344:_____/11:00364780!RIV12-MSM-60077344
http://linked.open...avai/predkladatel
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  • P(GA206/09/1782), P(KJB600960906), P(LC06009), Z(AV0Z60220518), Z(MSM6007665801)
http://linked.open...iv/cisloPeriodika
  • -
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  • 199592
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  • RIV/60077344:_____/11:00364780
http://linked.open...riv/jazykVysledku
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  • AMERICAN DOG TICK; INNATE IMMUNITY; DORIN-M; RHIPICEPHALUS-APPENDICULATUS; MOLECULAR CHARACTERIZATION; DERMACENTOR-VARIABILIS; ORNITHODOROS-MOUBATA; LECTINS; HEMOLYMPH; BINDING (en)
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  • GB - Spojené království Velké Británie a Severního Irska
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  • [CDE27D8083D1]
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  • 4
http://linked.open...iv/tvurceVysledku
  • Grubhoffer, Libor
  • Vancová, Marie
  • Štěrba, J.
  • Dupejová, J.
  • Fišer, M.
http://linked.open...ain/vavai/riv/wos
  • 000292963400001
http://linked.open...n/vavai/riv/zamer
issn
  • 1756-3305
number of pages
http://bibframe.org/vocab/doi
  • 10.1186/1756-3305-4-127
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