About: The Tick Salivary Protein Sialostatin L Inhibits the Th9-Derived Production of the Asthma-Promoting Cytokine IL-9 and Is Effective in the Prevention of Experimental Asthma     Goto   Sponge   NotDistinct   Permalink

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  • Ticks developed a multitude of different immune evasion strategies to obtain a blood meal. Sialostatin L is an immunosuppressive cysteine protease inhibitor present in the saliva of the hard tick Ixodes scapularis. In this study, we demonstrate that sialostatin L strongly inhibits the production of IL-9 by Th9 cells. Because we could show recently that Th9-derived IL-9 is essentially involved in the induction of asthma symptoms, sialostatin L was used for the treatment of experimental asthma. Application of sialostatin L in a model of experimental asthma almost completely abrogated airway hyperresponsiveness and eosinophilia. Our data suggest that sialostatin L can prevent experimental asthma, most likely by inhibiting the IL-9 production of Th9 cells. Thus, alternative to IL-9 neutralization sialostatin L provides the basis for the development of innovative therapeutic strategies to treat asthma. The Journal of Immunology, 2012, 188: 2669-2676.
  • Ticks developed a multitude of different immune evasion strategies to obtain a blood meal. Sialostatin L is an immunosuppressive cysteine protease inhibitor present in the saliva of the hard tick Ixodes scapularis. In this study, we demonstrate that sialostatin L strongly inhibits the production of IL-9 by Th9 cells. Because we could show recently that Th9-derived IL-9 is essentially involved in the induction of asthma symptoms, sialostatin L was used for the treatment of experimental asthma. Application of sialostatin L in a model of experimental asthma almost completely abrogated airway hyperresponsiveness and eosinophilia. Our data suggest that sialostatin L can prevent experimental asthma, most likely by inhibiting the IL-9 production of Th9 cells. Thus, alternative to IL-9 neutralization sialostatin L provides the basis for the development of innovative therapeutic strategies to treat asthma. The Journal of Immunology, 2012, 188: 2669-2676. (en)
Title
  • The Tick Salivary Protein Sialostatin L Inhibits the Th9-Derived Production of the Asthma-Promoting Cytokine IL-9 and Is Effective in the Prevention of Experimental Asthma
  • The Tick Salivary Protein Sialostatin L Inhibits the Th9-Derived Production of the Asthma-Promoting Cytokine IL-9 and Is Effective in the Prevention of Experimental Asthma (en)
skos:prefLabel
  • The Tick Salivary Protein Sialostatin L Inhibits the Th9-Derived Production of the Asthma-Promoting Cytokine IL-9 and Is Effective in the Prevention of Experimental Asthma
  • The Tick Salivary Protein Sialostatin L Inhibits the Th9-Derived Production of the Asthma-Promoting Cytokine IL-9 and Is Effective in the Prevention of Experimental Asthma (en)
skos:notation
  • RIV/60076658:12310/12:43883679!RIV13-MSM-12310___
http://linked.open...avai/predkladatel
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I, P(GCP302/11/J029), P(LC06009)
http://linked.open...iv/cisloPeriodika
  • 6
http://linked.open...vai/riv/dodaniDat
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  • 174429
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  • RIV/60076658:12310/12:43883679
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http://linked.open.../riv/klicovaSlova
  • DISEASE; ANTIBODY; EXPRESSION; INTERLEUKIN 9; TGF-BETA; EPITHELIAL-CELLS; AIRWAY INFLAMMATION; IXODES-SCAPULARIS; CD4(+) T-CELLS; CELL-MEDIATED SUPPRESSION (en)
http://linked.open.../riv/klicoveSlovo
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  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [254CF08E4C42]
http://linked.open...i/riv/nazevZdroje
  • Journal of Immunology
http://linked.open...in/vavai/riv/obor
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http://linked.open...v/svazekPeriodika
  • 188
http://linked.open...iv/tvurceVysledku
  • Kotsyfakis, Michalis
  • Kopecký, Jan
  • Andersen, John F.
  • Bopp, Tobias
  • Dehzad, Nina
  • Gerlitzki, Bastian
  • Hoffmann, Markus
  • Horká, Helena
  • Klein, Matthias
  • Reuter, Sebastian
  • Schild, Hansjoerg
  • Schmitt, Edgar
  • Stassen, Michael
  • Staudt, Valerie
  • Taube, Christian
http://linked.open...ain/vavai/riv/wos
  • 000301126000022
issn
  • 0022-1767
number of pages
http://bibframe.org/vocab/doi
  • 10.4049/jimmunol.1100529
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  • 12310
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