About: Molecular mechanisms of the cell proliferation and differentiation

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/domain/vavai/Projekt
rdfs:seeAlso	http://www.isvav.cz/projectDetail.do?rowId=GD204/08/H054
Description	Plants and animals evolved significantly different strategies of regulation of the cell proliferation and differentiation. Identification and comparison of molecular mechanisms driving those different strategies in plants, animals and microorganisms might contribute to the identification of their common principles. The project is based on collaboration of laboratories involved in the study of the processes of the cell proliferation and differentiation in those different model organisms including human beings. Collaboration of the laboratories with expertise in (i) molecular plant physiology, (ii) molecular mechanisms maintaining the genome stability, (iii) proliferation, differentiation and programmed cell death of cancer cells and (iv) bioinformatics will result into a multidisciplinary, while still functional team that will guarantee successful solution of scheduled tasks. Participation of multiple, recently collaborating laboratories including Core lab will allow effective employment of high-throughput instrumentation in the planned genomics and proteomics approaches. (en) Cílem projektu je koordinace vědecké činnosti studentů DSP zaměřené na procesy buněčné proliferace a diferenciace u mikrobiálních, rostlinných a živočišných systémů včetně člověka, jejich porovnání a vytvoření modelu obsahujícího specifické, ale i společné rysy jejich molekulární podstaty.
Title	Molecular mechanisms of the cell proliferation and differentiation (en) Molekulární mechanismy proliferace a diferenciace buněk
skos:notation	GD204/08/H054
http://linked.open...avai/cep/aktivita	Doctor grants
http://linked.open...kovaStatniPodpora	http://linked.opendata.cz/resource/domain/vavai/projekt/GD204%2F08%2FH054/celkovaStatniPodpora
http://linked.open...ep/celkoveNaklady	http://linked.opendata.cz/resource/domain/vavai/projekt/GD204%2F08%2FH054/celkoveNaklady
http://linked.open...datumDodatniDoRIV	2015-02-09 (xsd:date)
http://linked.open...i/cep/druhSouteze	VS - Veřejná soutěž ve výzkumu a vývoji
http://linked.open...ep/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open.../cep/fazeProjektu	91937718
http://linked.open...ai/cep/hlavniObor	EB - Genetika a molekulární biologie
http://linked.open...hodnoceniProjektu	V - Vynikající výsledky (s mezinárodním významem apod.). Zároveň byly splněny cíle a předpokládané výsledky uvedené ve smlouvě / rozhodnutí o poskytnutí podpory.
http://linked.open...vai/cep/kategorie	ZV - Základní výzkum
http://linked.open.../cep/klicovaSlova	regulace proliferace a diferenciace buněk; genomika a proteomika; rostlinné; živočišné a mikrobilární (en)
http://linked.open...ep/partnetrHlavni	Přírodovědecká fakulta
http://linked.open...inujicichPrijemcu	0 (xsd:int)
http://linked.open...cep/pocetPrijemcu	1 (xsd:int)
http://linked.open...ocetSpoluPrijemcu	0 (xsd:int)
http://linked.open.../pocetVysledkuRIV	69 (xsd:int)
http://linked.open...enychVysledkuVRIV	69 (xsd:int)
http://linked.open...lneniVMinulemRoce	2011-04-16 (xsd:date)
http://linked.open.../prideleniPodpory	http://linked.opendata.cz/resource/domain/vavai/cep/prideleniPodpory/204%2F08%2FH054
http://linked.open...iciPoslednihoRoku	2011
http://linked.open...atUdajeProjZameru	2012
http://linked.open.../vavai/cep/soutez	SGA02008GA-DG
http://linked.open...usZobrazovaneFaze	DUU
http://linked.open...ai/cep/typPojektu	P - Projekt výzkumu a vývoje financovaný ze státního rozpočtu
http://linked.open...ep/ukonceniReseni	2011-12-31 (xsd:date)
http://linked.open.../cep/vedlejsiObor	CB - Analytická chemie, separace IN - Informatika
http://linked.open...ep/zahajeniReseni	2008-01-01 (xsd:date)
http://linked.open...jektu+dodavatelem	The project gone according to plan both in terms of expertise and in terms of disbursement of funds. (en) Řešení projektu proběhlo podle plánu jak z hlediska odborného tak i z hlediska čerpání finančních prostředků. (cs)
http://linked.open...tniCyklusProjektu	ZBBKU
http://linked.open.../cep/klicoveSlovo	genomika a proteomika rostlinné regulace proliferace a diferenciace buněk
is http://linked.open...vavai/riv/projekt of	Telomere repeat binding protein variants show distinct kinetics and energetic nature of DNA-protein interaction Growth/differentiation factor-15 inhibits differentiation into osteoclasts - A novel factor involved in control of osteoclast differentiation Inhibition of topoisomerase IIa: Novel function of wedelolactone Interactions between the Nse3 and Nse4 Components of the SMC5-6 Complex Identify Evolutionarily Conserved Interactions between MAGE and EID Families The Overexpression of Cathepsin D Senzitizes Brest Cancer Cells to TRAIL-induced Apoptosis OVEREXPRESSION OF CATHEPSIN D SENZITIZES BREAST CANCER CELLS TO TRAIL-INDUCED APOPTOSIS The role of c-Myb in regulation of migration and invasivity of colon carcinoma cells Structure and binding specificity of the receiver domain of sensor histidine kinase CKI1 from Arabidopsis thaliana. c-Myb-induced migration/invasiveness of breast and colon cells in vitro is not associated with enhanced lung colonization in vivo c-Myb regulates MMP1, MMP9 and cathepsin D: Implications for the matrix-dependent breast cancer cell invasion and metastasis Functional characterization of domains in AtTRB1, a putative telomere-binding protein in Arabidopsis thaliana Expresní profily vybraných transkripčních faktorů v průběhu osteoklastové diferenciace Analýza exprese podjednotek NFkB u buněk leukemické linie BM2 metodou qRT-PCR Funkční interakce integrinu beta 3 a transkripčních faktorů c-jun a c-fos během diferenciace buněk RAW264.7 v-Myb suppresses phorbol ester- and modifies retinoic acid-induced differentiation of human promonocytic U937 cells Expresní profil transkripčního faktoru NFkB v buňkách leukemické linie BM2 Expresní profily genů c-jun, c-fos a integrinu beta 3 v průběhu diferenciace buněk RAW264.7 The effects of TGFb proteins on osteoclast differentiation Nestin expression in osteosarcomas and derivation of nestin/CD133 positive osteosarcoma cell lines. The identification of cells with cancer stem cell phenotype in osteosarcomas. Proteiny rodiny TGFbeta sekretované prostatickými nádorovými buňkami ovlivňují diferenciaci osteoklastů Single-Myb-histone proteins from Arabidopsis thaliana: a quantitative study of telomere-binding specifity and kinetics Protein c-Myb snižuje frekvenci apoptózy buněk karcinomu střeva bez účasti cyklooxygenázy 2 VÝZNAM AKTIVITY NFKB PRO MITOGENNÍ ÚČINEK PROKATEPSINU D NA BUŇKY KARCINOMU PRSU Protein c-Myb snižuje frekvenci apoptózy buněk karcinomu střeva bez účasti cyklooxygenázy 2 c-Myb prevents apoptosis of colon carcinoma cells in Cox-2-independent manner Analýza délky telomer u mutantů CAF1 Arabidopsis thaliana Konce chromozomů u rostlinné čeledi Alliaceae Characterization of a GM7 glioblastoma cell line showing CD133 positivity and both cytoplasmic and nuclear location of nestin Mechanismus vazby SMH proteinů na telomerickou DNA Aspergillus fumigatus host-interacting proteins - potential therapeutic targets Možnosti modulace ATRA-indukované diferenciace neuroblastomových a meduloblastomových buněčných linií působením LOX/COX inhibitorů. IDENTIFICATION OF GENES PARTICIPATING IN THE REGULATION OF CKI1 EXPRESSION USING FORWARD GENETIC APPROACH Cytokinins modulate auxin-induced organogenesis in plants via regulation of the auxin efflux The Solution Structure of the ADAR2 dsRBM-RNA Complex Reveals a Sequence-Specific Readout of the Minor Groove The use of Cox-2 and PPAR gamma signaling in anti-cancer therapies (Review) Crystallization and initial X-ray diffraction studies of the flavoenzyme NAD(P)H:(acceptor) oxidoreductase (FerB) from the soil bacterium Paracoccus denitrificans Analysis of the Nse3/MAGE-binding Domain of the Nse4/EID Family Proteins Redox State Alters Anti-Cancer Effects of Wedelolactone Application of fluorescence anisotropy to monitor protein binding to telomeric DNA Aspergillus fumigatus host-interacting proteins - potential therapeutic targets The effects of wedelolactone on cancer cells depend on its redox state c-Myb regulates matrix metalloproteinases 1/9, and cathepsin D: implications for matrix-dependent breast cancer cell invasion and metastasis Characterization of the DMD/BMD patient population in Czech Republic and Slovakia using an innovative registry approach Influence of LOX/COX inhibitors on cell differentation induced by all-trans retinoic acid in neuroblastoma cell lines. CHARACTERISATION OF HUMAN HISTONE N TERMINAL ACETYLATIONS Analysis of interaction domains of plant telomere-binding proteins AtTRB1 and AtPOT1b Interactions of the receiver domain in histidine kinase receptors with the AHP proteins Cathepsin D expression as a regulator of breast cancer cell migration and chemosensitivity CD133 expression and identification of CD133/nestin positive cells in rhabdomyosarcomas and rhabdomyosarcoma cell lines Mass Spectrometry Characterization of Plant Phosphoproteins Prognostic impact of p53 aberrations for R-CHOP-treated patients with diffuse large B-cell lymphoma Recognition of transcription termination signal by the nuclear polyadenylated RNA-binding (Nab)3 protein Wedelolactone inhibits proliferation and induces differentiation and/or apoptosis of breast cancer cells Wedelolactone suppresses growth and induces differentiation and apoptosis of breast cancer cells Electrophoretic fingerprint metallothionein analysis as a potential prostate cancer biomarker Funkční interakce integrinu beta 3 a transkripčních faktorů c-jun a c-fos během diferenciace buněk RAW264.7 Expresní profily genů c-jun, c-fos a integrinu beta 3 v průběhu diferenciace buněk RAW264.7 Identification of genes participating in the regulation of CKI1 expression using forward genetic approach

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