About: Influence of LOX/COX inhibitors on cell differentation induced by all-trans retinoic acid in neuroblastoma cell lines.

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Influence of LOX/COX inhibitors on cell differentation induced by all-trans retinoic acid in neuroblastoma cell lines. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We investigated the possible modulation by LOX/ COX inhibitors of all-trans retinoic acid (ATRA)-induced cell differentiation in two established neuroblastoma cell lines, SH-SY5Y and SK-N-BE(2). Caffeic acid, as an inhibitor of 5-lipoxygenase, and celecoxib, as an inhibitor of cyclooxygenase-2, were chosen for this study. The effects of the combined treatment with ATRA and LOX/COX inhibitors on neuroblastoma cells were studied using cell morphology assessment, detection of differentiation markers by immunoblotting, measurement of proliferation activity, and cell cycle analysis and apoptosis detection by flow cytometry. The results clearly demonstrated the potential of caffeic acid to enhance ATRA-induced cell differentiation, especially in the SK-N-BE(2) cell line, whereas application of celecoxib alone or with ATRA led predominantly to cytotoxic effects in both cell lines. We investigated the possible modulation by LOX/ COX inhibitors of all-trans retinoic acid (ATRA)-induced cell differentiation in two established neuroblastoma cell lines, SH-SY5Y and SK-N-BE(2). Caffeic acid, as an inhibitor of 5-lipoxygenase, and celecoxib, as an inhibitor of cyclooxygenase-2, were chosen for this study. The effects of the combined treatment with ATRA and LOX/COX inhibitors on neuroblastoma cells were studied using cell morphology assessment, detection of differentiation markers by immunoblotting, measurement of proliferation activity, and cell cycle analysis and apoptosis detection by flow cytometry. The results clearly demonstrated the potential of caffeic acid to enhance ATRA-induced cell differentiation, especially in the SK-N-BE(2) cell line, whereas application of celecoxib alone or with ATRA led predominantly to cytotoxic effects in both cell lines. (en)
Title	Influence of LOX/COX inhibitors on cell differentation induced by all-trans retinoic acid in neuroblastoma cell lines. Influence of LOX/COX inhibitors on cell differentation induced by all-trans retinoic acid in neuroblastoma cell lines. (en)
skos:prefLabel	Influence of LOX/COX inhibitors on cell differentation induced by all-trans retinoic acid in neuroblastoma cell lines. Influence of LOX/COX inhibitors on cell differentation induced by all-trans retinoic acid in neuroblastoma cell lines. (en)
skos:notation	RIV/65269705:_____/10:#0001023!RIV11-MZ0-65269705
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GD204/08/H054), P(NR9341), Z(MSM0021622415)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Veselská, Renata Štěrba, Jaroslav Loja, Tomáš Zitterbart, Karel Hermanová, Markéta
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Brno / (nerozlišená součást)
http://linked.open...dnocenehoVysledku	263696
http://linked.open...ai/riv/idVysledku	RIV/65269705:_____/10:#0001023
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	neuroblastoma (en)
http://linked.open.../riv/klicoveSlovo	neuroblastoma
http://linked.open...odStatuVydavatele	GR - Řecká republika
http://linked.open...ontrolniKodProRIV	[4285ACEBFDE0]
http://linked.open...i/riv/nazevZdroje	International Journal of Molecular Medicine
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Molecular mechanisms of the cell proliferation and differentiation Modulation of antineoplastic effect of retinoids by LOX/COX inhibitors on the model of solid childhood tumors: in vitro study
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	25
http://linked.open...iv/tvurceVysledku	Hermanová, Markéta Loja, Tomáš Veselská, Renata Zitterbart, Karel Štěrba, Jaroslav
http://linked.open...ain/vavai/riv/wos	000273862300013
http://linked.open...n/vavai/riv/zamer	Molecular basis of cell and tissue regulations
issn	1107-3756
number of pages	9 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Influence of LOX/COX inhibitors on cell differentation induced by all-trans retinoic acid in neuroblastoma cell lines. Influence of LOX/COX inhibitors on cell differentation induced by all-trans retinoic acid in neuroblastoma cell lines. Influence of LOX/COX inhibitors on cell differentation induced by all-trans retinoic acid in neuroblastoma cell lines.

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 47 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software