About: Prognostic impact of p53 aberrations for R-CHOP-treated patients with diffuse large B-cell lymphoma

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About: Prognostic impact of p53 aberrations for R-CHOP-treated patients with diffuse large B-cell lymphoma Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We performed complex analysis of the p53 tumor suppressor in collection of 75 DLBCL cases. Fifty four patients were de novo cases, twenty one cases developed into DLBCL by transformation from less aggressive disease. We determined functional status by analysis of separated alleles in yeast (FASAY) and analyzed the p53 mutations by cDNA sequencing. We assessed the level of the p53 protein by immunoblotting analysis. We used FISH to analyze loss of the p53 and ATM (ataxia telangiectasia mutated) genes deletion. We detected 16 p53 mutations (21.3%) including the mutation activating nonsense-mediated RNA decay pathway. Deletion of the p53 allele was more common in cases with p53 mutation. Mutations and/or deletions of p53 had statistically significant negative impact on progression-free survival and tended to decrease also overall survival in 46 de novo DLBCL patients treated with R-CHOP. p53 aberrations are negative predictors for survival of DLBCL patients treated with R-CHOP. We performed complex analysis of the p53 tumor suppressor in collection of 75 DLBCL cases. Fifty four patients were de novo cases, twenty one cases developed into DLBCL by transformation from less aggressive disease. We determined functional status by analysis of separated alleles in yeast (FASAY) and analyzed the p53 mutations by cDNA sequencing. We assessed the level of the p53 protein by immunoblotting analysis. We used FISH to analyze loss of the p53 and ATM (ataxia telangiectasia mutated) genes deletion. We detected 16 p53 mutations (21.3%) including the mutation activating nonsense-mediated RNA decay pathway. Deletion of the p53 allele was more common in cases with p53 mutation. Mutations and/or deletions of p53 had statistically significant negative impact on progression-free survival and tended to decrease also overall survival in 46 de novo DLBCL patients treated with R-CHOP. p53 aberrations are negative predictors for survival of DLBCL patients treated with R-CHOP. (en)
Title	Prognostic impact of p53 aberrations for R-CHOP-treated patients with diffuse large B-cell lymphoma Prognostic impact of p53 aberrations for R-CHOP-treated patients with diffuse large B-cell lymphoma (en)
skos:prefLabel	Prognostic impact of p53 aberrations for R-CHOP-treated patients with diffuse large B-cell lymphoma Prognostic impact of p53 aberrations for R-CHOP-treated patients with diffuse large B-cell lymphoma (en)
skos:notation	RIV/00216224:14310/11:00050476!RIV12-MZ0-14310___
http://linked.open...avai/predkladatel	Přírodovědecká fakulta
http://linked.open...avai/riv/aktivita	I P V Z
http://linked.open...avai/riv/aktivity	I, P(GD204/08/H054), P(NR9305), P(NS10448), V, Z(MSM0021622415)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Vranová, Vladimíra Mužík, Jan Kuglík, Petr Zedek, František Šmardová, Jana Štefančíková, Lenka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	224377
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/11:00050476
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	diffuse large B-cell lymphoma; tumor suppressor p53; FASAY; overall survival; progression free survival (en)
http://linked.open.../riv/klicoveSlovo	overall survival FASAY progression free survival tumor suppressor p53 diffuse large B-cell lymphoma
http://linked.open...odStatuVydavatele	GR - Řecká republika
http://linked.open...ontrolniKodProRIV	[CC7543916379]
http://linked.open...i/riv/nazevZdroje	International Journal of Oncology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...vavai/riv/projekt	Molecular mechanisms of the cell proliferation and differentiation Detailed analyses of temperature-dependent mutants of the p53 tumor suppressor in human cells Complex analysis of p53 tumor suppressor in non-Hodgkin´s lymphomas
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	39
http://linked.open...iv/tvurceVysledku	Kuglík, Petr Moulis, Mojmír Ravčuková, Barbora Vranová, Vladimíra Zedek, František Mužík, Jan Vášová, Ingrid Šmardová, Jana Fabian, Pavel Falková, Iva Hrabálková, Renata Štefančíková, Lenka
http://linked.open...ain/vavai/riv/wos	000296315400009
http://linked.open...n/vavai/riv/zamer	Molecular basis of cell and tissue regulations
issn	1019-6439
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.3892/ijo.2011.1170
http://localhost/t...ganizacniJednotka	14310
is http://linked.open...avai/riv/vysledek of	Prognostic impact of p53 aberrations for R-CHOP-treated patients with diffuse large B-cell lymphoma Prognostic impact of p53 aberrations for R-CHOP-treated patients with diffuse large B-cell lymphoma

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