About: Detailed analyses of temperature-dependent mutants of the p53 tumor suppressor in human cells     Goto   Sponge   NotDistinct   Permalink

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  • We propose to perform detailed analysis of 23 temperature-dependent mutants of the p53 tumor suppressor in H1299 human cells to determine the level of temperature-dependency, discriminative character and susceptibility to reactivation by amifostine. (en)
  • Navrhujeme podrobnou analýzu 23 teplotně závislých mutantů nádorového supresoru p53 v lidských buňkách H1299: určení stupně teplotní senzitivity, diskriminativního charakteru a možnosti jejich reaktivace amifostinem.
Title
  • Detailed analyses of temperature-dependent mutants of the p53 tumor suppressor in human cells (en)
  • Podrobná analýza teplotně závislých mutantů nádorového supresoru p53 v lidských buňkách
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  • NS10448
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  • p53 tumor suppressor; temperature-dependent mutants; discriminative mutants; p53 reactivation; amifostine (en)
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  • Výsledky analýzy 23 teplotně sensitivních mutant gemu p53 v lidských buňkách dávají možnost cílů pro terapii CLL a jiných onkohematologických onemocnění. (cs)
  • Results of analysis of 23 temperature- sensitive mutants in human cells provide a possibility for tratment of CLL and other oncohematological diseases. (en)
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  • p53 tumor suppressor
  • discriminative mutants
  • p53 reactivation
  • temperature-dependent mutants
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