About: The effects of TGFb proteins on osteoclast differentiation

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Bones are preferential targets of disseminating prostate cancer cells. Homing and activity of cancer cells in the bone microenvironment as well as specific mechanisms used by tumor cells remain to be elucidated. Te aim of this study is to describe the effects of three members of the TGFb protein family (TGFb, BMP-7 and GDF-15) on RANKL-induced osteoclast differentiation of murine cells RAW264.7. These proteins are secreted by prostate cancer cells LNCaP, possess strong morphogenic effects and affect the bone microenvironment. We found that TGFb accelerated the RANKL-induced differentiation of RAW264.7 cells to active osteoclasts and induced expression of several osteoclast-associated genes. In contrast, the BMP-7 and GDF-15 cytokines suppressed the RANKL-induced osteoclast differentiation and silenced expression of the osteoclast-associated genes. We conclude that different members of the TGFb protein family play different roles in regulation of signals driving formation of osteoclasts. Bones are preferential targets of disseminating prostate cancer cells. Homing and activity of cancer cells in the bone microenvironment as well as specific mechanisms used by tumor cells remain to be elucidated. Te aim of this study is to describe the effects of three members of the TGFb protein family (TGFb, BMP-7 and GDF-15) on RANKL-induced osteoclast differentiation of murine cells RAW264.7. These proteins are secreted by prostate cancer cells LNCaP, possess strong morphogenic effects and affect the bone microenvironment. We found that TGFb accelerated the RANKL-induced differentiation of RAW264.7 cells to active osteoclasts and induced expression of several osteoclast-associated genes. In contrast, the BMP-7 and GDF-15 cytokines suppressed the RANKL-induced osteoclast differentiation and silenced expression of the osteoclast-associated genes. We conclude that different members of the TGFb protein family play different roles in regulation of signals driving formation of osteoclasts. (en)
Title	The effects of TGFb proteins on osteoclast differentiation The effects of TGFb proteins on osteoclast differentiation (en)
skos:prefLabel	The effects of TGFb proteins on osteoclast differentiation The effects of TGFb proteins on osteoclast differentiation (en)
skos:notation	RIV/00216224:14310/08:00024950!RIV11-GA0-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/06/0036), P(GD204/08/H054), Z(MSM0021622415)
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Slabáková, Eva Vaňhara, Petr Souček, Karel Šmarda, Jan
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	365436
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/08:00024950
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	osteoclasts; TGF beta; prostate cancer (en)
http://linked.open.../riv/klicoveSlovo	TGF beta osteoclasts prostate cancer
http://linked.open...ontrolniKodProRIV	[2B7AF312C897]
http://linked.open...v/mistoKonaniAkce	Hersonissos, Greece
http://linked.open...i/riv/mistoVydani	Hersonissos, Greece
http://linked.open...i/riv/nazevZdroje	Proceedings of the abstracts of the 13th World Congress on Advances in Oncology and 11th International Symposium on Molecular Medicine
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Molecular mechanisms of the cell proliferation and differentiation A role of certain transcription factors in the osteoclastic differentiation pathway
http://linked.open...UplatneniVysledku	2008
http://linked.open...iv/tvurceVysledku	Slabáková, Eva Souček, Karel Šmarda, Jan Vaňhara, Petr
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open.../riv/zahajeniAkce	2008-01-01 (xsd:date)
http://linked.open...n/vavai/riv/zamer	Molecular basis of cell and tissue regulations
issn	1107-3756
number of pages	2 (xsd:int)
http://purl.org/ne...btex#hasPublisher	International Journal of Molecular Medicine Vol. 22, supplement 1, 2008
http://localhost/t...ganizacniJednotka	14310
is http://linked.open...avai/riv/vysledek of	The effects of TGFb proteins on osteoclast differentiation The effects of TGFb proteins on osteoclast differentiation The effects of TGFb proteins on osteoclast differentiation

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