About: OVEREXPRESSION OF CATHEPSIN D SENZITIZES BREAST CANCER CELLS TO TRAIL-INDUCED APOPTOSIS

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Breast cancer cells overexpressing cathepsin D wt and mut were exposed to TRAIL and frequency of apoptosis was determined by chromatin condensation, nuclear fragmentation, cleavage of PARP, and externalization of phosphatidylserine. An increased frequency of apoptosis in cells over-expressing wt but not mut CTSD was clearly demonstrated. Increased frequency of apoptosis observed in wt CTSD cells corresponded to cleavage of the pro-apoptotic Bcl-2 family member, the Bid protein, that was earlier identified as one of the targets of CTSD in cancer cells. We conclude that CTSD sensitizes MDA-MB-231 cells to the TRAIL-induced apoptosis in enzymatic activity-dependent manner and that the TRAIL-induced apoptosis is potentiated by the CTSD-mediated activation of Bid, the pro-apoptotic member of the Bcl-2 family. Breast cancer cells overexpressing cathepsin D wt and mut were exposed to TRAIL and frequency of apoptosis was determined by chromatin condensation, nuclear fragmentation, cleavage of PARP, and externalization of phosphatidylserine. An increased frequency of apoptosis in cells over-expressing wt but not mut CTSD was clearly demonstrated. Increased frequency of apoptosis observed in wt CTSD cells corresponded to cleavage of the pro-apoptotic Bcl-2 family member, the Bid protein, that was earlier identified as one of the targets of CTSD in cancer cells. We conclude that CTSD sensitizes MDA-MB-231 cells to the TRAIL-induced apoptosis in enzymatic activity-dependent manner and that the TRAIL-induced apoptosis is potentiated by the CTSD-mediated activation of Bid, the pro-apoptotic member of the Bcl-2 family. (en)
Title	OVEREXPRESSION OF CATHEPSIN D SENZITIZES BREAST CANCER CELLS TO TRAIL-INDUCED APOPTOSIS OVEREXPRESSION OF CATHEPSIN D SENZITIZES BREAST CANCER CELLS TO TRAIL-INDUCED APOPTOSIS (en)
skos:prefLabel	OVEREXPRESSION OF CATHEPSIN D SENZITIZES BREAST CANCER CELLS TO TRAIL-INDUCED APOPTOSIS OVEREXPRESSION OF CATHEPSIN D SENZITIZES BREAST CANCER CELLS TO TRAIL-INDUCED APOPTOSIS (en)
skos:notation	RIV/00216224:14310/11:00049487!RIV12-GA0-14310___
http://linked.open...avai/predkladatel	Přírodovědecká fakulta
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/09/1115), P(GD204/08/H054), P(IAA501630801), Z(MSM0021622415)
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Šmarda, Jan Ondroušková, Eva
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	219224
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/11:00049487
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	apoptosis; TRAIL; cathepsin D; breast cancer (en)
http://linked.open.../riv/klicoveSlovo	breast cancer cathepsin D TRAIL apoptosis
http://linked.open...ontrolniKodProRIV	[2FD78F99C910]
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	The role of c-Myb and Cox-2 proteins in colon carcinogenesis Molecular mechanisms of the cell proliferation and differentiation Mechanism of procathepsin D effect on breast cancer cells
http://linked.open...UplatneniVysledku	2011
http://linked.open...iv/tvurceVysledku	Beneš, Petr Jančeková, Blanka Šmarda, Jan Ondroušková, Eva
http://linked.open...n/vavai/riv/zamer	Molecular basis of cell and tissue regulations
http://localhost/t...ganizacniJednotka	14310

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