About: Electrophoretic fingerprint metallothionein analysis as a potential prostate cancer biomarker

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Prostate-specific antigen (PSA) is a routinely used marker of prostate cancer; however, the cut-off values for unambiguous positive/negative prostate cancer diagnoses are not defined. Therefore, despite the best effort, certain percentage of misdiagnosed cases is being recorded every year. For this reason, search formore specific diagnosticmarkers is of great interest. In this study, systematic comparison of PSA and metallothionein (MT) levels in blood serum of 46 prostate cancer-diagnosed patients is presented. It is clearly demonstrated that PSA levels vary significantly and despite normal total PSA values in the range of 0 - 4 ng/mL were obtained in over 36.9% of cases, positive prostate cancer was diagnosed by biopsy. In contrary, MT levels were considerably elevated in all tested samples and no significant variations were observed. These results are indicating the potential of MT as an additional prostate cancer marker reducing, in combination with PSA, the probability of false positive/negative Prostate-specific antigen (PSA) is a routinely used marker of prostate cancer; however, the cut-off values for unambiguous positive/negative prostate cancer diagnoses are not defined. Therefore, despite the best effort, certain percentage of misdiagnosed cases is being recorded every year. For this reason, search formore specific diagnosticmarkers is of great interest. In this study, systematic comparison of PSA and metallothionein (MT) levels in blood serum of 46 prostate cancer-diagnosed patients is presented. It is clearly demonstrated that PSA levels vary significantly and despite normal total PSA values in the range of 0 - 4 ng/mL were obtained in over 36.9% of cases, positive prostate cancer was diagnosed by biopsy. In contrary, MT levels were considerably elevated in all tested samples and no significant variations were observed. These results are indicating the potential of MT as an additional prostate cancer marker reducing, in combination with PSA, the probability of false positive/negative (en)
Title	Electrophoretic fingerprint metallothionein analysis as a potential prostate cancer biomarker Electrophoretic fingerprint metallothionein analysis as a potential prostate cancer biomarker (en)
skos:prefLabel	Electrophoretic fingerprint metallothionein analysis as a potential prostate cancer biomarker Electrophoretic fingerprint metallothionein analysis as a potential prostate cancer biomarker (en)
skos:notation	RIV/00216305:26220/11:PU93066!RIV15-MSM-26220___
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(GA102/07/1473), P(GD102/09/H083), P(GD204/08/H054), P(GP301/09/P436), P(KAN208130801), P(NS10200), S, Z(MSM0021630513)
http://linked.open...iv/cisloPeriodika	32
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Provazník, Ivo Adam, Vojtěch Hubálek, Jaromír Kizek, René
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoké učení technické v Brně / Fakulta elektrotechniky a komunikačních technologií
http://linked.open...dnocenehoVysledku	197143
http://linked.open...ai/riv/idVysledku	RIV/00216305:26220/11:PU93066
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Blood marker, Glutathione, Metallothionein, Prostate cancer, Prostate-specific antigen (en)
http://linked.open.../riv/klicoveSlovo	Metallothionein Blood marker Prostate cancer Prostate-specific antigen Glutathione
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[870F6AFEA52D]
http://linked.open...i/riv/nazevZdroje	Electrophoresis
http://linked.open...in/vavai/riv/obor	CG
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Optical Methods for Registration of Heart Electrical Potentials and Calcium Concentration with Laser Stabilization Information Technology in Biomedical Engineering Molecular mechanisms of the cell proliferation and differentiation Metallothionein analysis in prostate carcinoma at DNA, RNA and protein level. New design and exploiting nanobiosensors and nanosensors to target medicine (NANOSEMED) Tumor markers, their determination and correlation with prostate carcinoma
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	2011
http://linked.open...iv/tvurceVysledku	Adam, Vojtěch Gumulec, Jaromír Hubálek, Jaromír Kizek, René Křížková, Soňa Majzlík, Petr Masařík, Michal Provazník, Ivo Vaculovičová, Markéta
http://linked.open...n/vavai/riv/zamer	Advanced Electronic Communication Systems and Technologies (ELCOM)
issn	0173-0835
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	26220

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