About: c-Myb-induced migration/invasiveness of breast and colon cells in vitro is not associated with enhanced lung colonization in vivo

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About: c-Myb-induced migration/invasiveness of breast and colon cells in vitro is not associated with enhanced lung colonization in vivo Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Metastasis formation and spread of primary tumors are the leading causes of death in cancer patients. To develop new treatment strategies, a clarification of the processes involved in the metastasis development is required. The c-Myb transcription factor is essential regulator of stem-progenitor cells in bone marrow, colon epithelia and neurogenic niches in brain. Malfunction of c-Myb results in malignancies of several types. The role of c-Myb in regulation of proliferation, differentiation and apoptosis is well established. In contrast, current knowledge on the role of c-Myb in control of metastasis formation remains poor. We have reported recently, that c-Myb promotes migration/invasion of human breast cancer MDA-MB-231 cells via upregulation of cathepsin D and MMP9. This study shows that overexpression of c-myb enhances migration and invasion of murine breast cancer 4T1 cells and murine colon cancer CT26 cells in vitro as well. Metastasis formation and spread of primary tumors are the leading causes of death in cancer patients. To develop new treatment strategies, a clarification of the processes involved in the metastasis development is required. The c-Myb transcription factor is essential regulator of stem-progenitor cells in bone marrow, colon epithelia and neurogenic niches in brain. Malfunction of c-Myb results in malignancies of several types. The role of c-Myb in regulation of proliferation, differentiation and apoptosis is well established. In contrast, current knowledge on the role of c-Myb in control of metastasis formation remains poor. We have reported recently, that c-Myb promotes migration/invasion of human breast cancer MDA-MB-231 cells via upregulation of cathepsin D and MMP9. This study shows that overexpression of c-myb enhances migration and invasion of murine breast cancer 4T1 cells and murine colon cancer CT26 cells in vitro as well. (en)
Title	c-Myb-induced migration/invasiveness of breast and colon cells in vitro is not associated with enhanced lung colonization in vivo c-Myb-induced migration/invasiveness of breast and colon cells in vitro is not associated with enhanced lung colonization in vivo (en)
skos:prefLabel	c-Myb-induced migration/invasiveness of breast and colon cells in vitro is not associated with enhanced lung colonization in vivo c-Myb-induced migration/invasiveness of breast and colon cells in vitro is not associated with enhanced lung colonization in vivo (en)
skos:notation	RIV/00216224:14310/11:00049435!RIV12-GA0-14310___
http://linked.open...avai/predkladatel	Přírodovědecká fakulta
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/09/1115), P(GD204/08/H054), P(IAA501630801), Z(MSM0021622415)
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Beneš, Petr Šmarda, Jan Pekarčíková, Lucie Knopfová, Lucia
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	190688
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/11:00049435
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	c-Myb; cell invasion; lung colonization; metastasis (en)
http://linked.open.../riv/klicoveSlovo	c-Myb cell invasion lung colonization metastasis
http://linked.open...ontrolniKodProRIV	[A096EDD49D27]
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	The role of c-Myb and Cox-2 proteins in colon carcinogenesis Molecular mechanisms of the cell proliferation and differentiation Mechanism of procathepsin D effect on breast cancer cells
http://linked.open...UplatneniVysledku	2011
http://linked.open...iv/tvurceVysledku	Beneš, Petr Knopfová, Lucia Masařík, Michal Pekarčíková, Lucie Pernicová, Zuzana Souček, Karel Šmarda, Jan
http://linked.open...n/vavai/riv/zamer	Molecular basis of cell and tissue regulations
http://localhost/t...ganizacniJednotka	14310

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