About: Biophysics of dynamic structures and functions of biological systems

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Zamer, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/domain/vavai/Zamer
Description	Research will be focused on: relations between the primary structure of the DNA and its conformational properties, with respect to evolution of genomes interactions of DNA with proteins (histones, HMG proteins, oncoproteins) and with metal-containing anticancer drugsinteractions of DNA and proteins in interphases in the relation to chemical sensors developed for genomics and proteomics the architecture of the cell nucleus, organisation and modifications of chromatin, structure and function of nucleoproteins and telomeric complexes, dynamics of genomes and genomic territories relations between gene expression, cell differentiation, oncogenic transformation and development effects of endo- and exogenous mediators modifying proliferation, differentiation and apoptosis in cell populations computer simulations of dynamic structures and interactions of DNA/RNA with proteins and biologically active compounds. Applications will be directed to medicine, agrobiology, ecotoxicology and biotechno (en) Výzkum bude zaměřen na vztahy mezi primární strukturu DNA a jejími konformačními vlastnostmi, s ohledem na evoluci genomů, interakce DNA s proteiny (histony, HMG proteiny, onkoproteiny) a s protinádorově účinnými látkami obsahujícími kovy, interakce DNA a proteinů v mezifázích ve vztahu k elektrochemických senzorům pro genomiku a proteomiku, architekturu buněčného jádra, uspořádání a modifikace chromatinu, strukturu a funkci nukleoproteinů a telomerických komplexů, dynamiku genomů a genomových teritorií, vztahy mezi genovou expresí, buněčnou diferenciací, onkogenní transformací a ontogenetickým vývojem, vliv endo- a exogenních mediátorů modifikujících proliferaci, diferenciaci a apoptózu v buněčných populacích, počítačové simulace dynamické struktury a interakcí DNA/RNA s proteiny a biologicky aktivními látkami. Aplikace budou směřovat do medicíny, agrobiologie, ekotoxikologie a biotechnologií.
Title	Biophysics of dynamic structures and functions of biological systems (en) Biofyzika dynamických struktur a funkcí biologických systémů
http://linked.open...kovaStatniPodpora	http://linked.opendata.cz/resource/domain/vavai/zamer/AV0Z50040507/celkovaStatniPodpora
http://linked.open...ez/celkoveNaklady	http://linked.opendata.cz/resource/domain/vavai/zamer/AV0Z50040507/celkoveNaklady
http://linked.open...datumDodatniDoRIV	2012-07-03 (xsd:date)
http://linked.open...vavai/cez/dodavka	http://linked.opendata.cz/resource/domain/vavai/dodavka/CEZ12-AV0-U%2F01%3A1
http://linked.open...ez/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...in/vavai/cez/faze	33135364
http://linked.open...ai/cez/hlavniObor	BO - Biofyzika
http://linked.open...vai/cez/hodnoceni	V - Vynikající výsledky (s mezinárodním významem apod.). Zároveň byly splněny cíle a předpokládané výsledky uvedené ve smlouvě / rozhodnutí o poskytnutí podpory.
http://linked.open.../cez/kategorieVaV	ZV - Základní výzkum
http://linked.open.../cez/klicovaSlova	molecular dynamics; DNA-protein interactions; biosensors; anticancer drugs; HMG proteins; DNA-conformations; microsatelites; epigenetics; genome structure; nuclear architecture; cytokinins; cytokinetics; antioxidative processes; haematopoiesis (en)
http://linked.open...cez/partnerHlavni	Biofyzikální ústav AV ČR, v.v.i.
http://linked.open...z/poceVysledkuRIV	896 (xsd:int)
http://linked.open...inujicichPrijemcu	0 (xsd:int)
http://linked.open...cez/pocetPrijemcu	1 (xsd:int)
http://linked.open...ocetSpoluPrijemcu	0 (xsd:int)
http://linked.open...enychVysledkuVRIV	896 (xsd:int)
http://linked.open...lneniVMinulemRoce	2011-12-06 (xsd:date)
http://linked.open.../prideleniPodpory	http://linked.opendata.cz/resource/domain/vavai/cez/prideleniPodpory/AV0Z50040507
http://linked.open.../vavai/cez/resort	Academy of Sciences of the Czech Republic
http://linked.open...iciPoslednihoRoku	2011
http://linked.open...atUdajeProjZameru	2012
http://linked.open...usZobrazovaneFaze	DUU
http://linked.open...ez/ukonceniReseni	2011-12-31 (xsd:date)
http://linked.open...ez/zahajeniReseni	2005-01-01 (xsd:date)
http://linked.open...n/vavai/cez/zamer	Z - Výzkumný záměr financovaný ze státního rozpočtu
http://linked.open...sledkuDodavatelem	Byly studovány buňky a biomolekuly metodami biofyziky. Byly získány originální poznatky o struktuře DNA a jejich interakcích s proteiny nebo farmaky, o uspořádání DNA v rámci chromosomů a genomů, o reparaci DNA, telomerách chromosomů, cytokinetice, imunitní odpovědi buněk, evoluci pohlavních chromosomů, epigenetice a další. Tyto poznatky jsou důležité pro základní výzkum i pro aplikace. (cs) Cells and biomolecules were investigated using biophysical methods. Original results on DNA structure and its interactions with proteins and pharmaceuticals, on the arrangement of the genome, DNA repair, on telomeres, cytokinetics, immune responses of cells, on evolution of sex chromosemes, epigenetics etc. were obtained. These results are important for both basic research and applications. (en)
http://linked.open...cez/zivotniCyklus	ZBBBBBKU
is http://linked.open...n/vavai/riv/zamer of	Interaction of polyunsaturated fatty acids and sodium butyrate during apoptosis in HT-29 human colon adenocarcinoma cells Spectroscopic methods Action of granulopoiesis-stimulating cytokines rhG-CSF, rhGM-CSF, and rmGM-CSF on murine hematopoietic progenitor cells for granulocytes and macrophages (GM-CFC) Rapid concerted evolution of nuclear ribosomal DNA in two tragopogon allopolyploids of recent and recurrent origin Preferential elimination of repeated DNA sequences from the paternal, Nicotiana tomentosiformis genome donor of a synthetic, allotetraploid tobacco Molecular cytogenetics and tandem repeat sequence evolution in the allopolyploid Nicotiana rustica compared with diploid progenitors N. paniculata and N. undulata Conformational properties of DNA containing (CCA)n and (TGG)n trinucleotide repeats Vznik života na Zemi. Fakta a (pseudo)interpretace Metal cation-nucleic acids interactions Principles of RNA base pairing: Structures and energies of the trans Watson-Crick/sugar edge base pairs Electrochemical sensors based on stationary electrodes and immobilized DNA or its fragments and the assessment of their analytical potentials Rostlinné DNA-(cytosin-5)-methyltransferasy Electrochemical responses of thiolated oligodeoxynucleotides in cobalt-containing solutions Sequestering of p53 into DNA-protein filaments revealed by electron microscopy Electrochemical methods Polyploidie dokáže s rostlinnými genomy pořádně zatřást Electrochemical DNA sensors DNA adducts of the enantiomers of the Pt(II) complexes of the ahaz ligand (ahaz=3-aminohexahydroazepine) and recognition of these adducts by HMG domain proteins Thermal stability and energetics of 15-mer DNA duplex interstrand crosslinked by trans-diamminedichloroplatinum(II) Chiral differentiation of DNA adducts formed by enantiomeric analogues of antitumor cisplatin is sequence-dependent Effects of monofunctional adducts of Platinum(II) complexes on thermodynamic stability and energetics of DNA duplexes Platinum-based drugs The effects of parenteral lipid emulsions on cancer and normal human colon epithelial cells in vitro A gradual process of recombination restriction in the evolutionary history of the sex chromosomes in dioecious plants An analysis of avidin, biotin and their interaction at attomole levels by voltammetric and chromatographic techniques Účinky mateřské lásky na molekulární úrovni Are the hydrogen bonds of RNA (.U) stronger than those of DNA (A.T)? A quantum mechanics study Dedifferentiation of tobacco cells is associated with ribosomal RNA gene hypomethylation, increased transcription, and chromatin alterations Telomerase-independent cell survival in Arabidopsis thaliana Hinge-like motions in RNA Kink-turns: The role of the second A-minor motif and nominally unpaired bases Analysis of plant telomere-binding protein Sugar edge/sugar edge base pairs in RNA: Stabilities and structures from quantum chemical calculations Modifications of DNA by platinum complexes. Relation to resistance of tumors to platinum antitumor drugs Guanine tetraplex topology of human telomere DNA is governed by the number of (TTAGGG) repeats Mechanism of the anti-tumor activity of platinum complexes MET signalling in primary colon epithelial cells leads to increased transformation irrespective of aberrant Wnt signalling Binding of mutant and wild type p53 proteins to supercoiled DNA Metal compounds in cancer chemotherapy The inter-specific hybrid Silene latifolia x S. viscosa reveals early events of sex chromosome evolution TRAIL and docosahexaenoic acid cooperate to induce HT-29 colon cancer cell death High effectiveness of platinum(IV) complex with adamantylamine in overcoming resistance to cisplatin and suppressing proliferation of ovarian cancer cells in vitro Electrochemistry of nucleic acids and proteins - towards electrochemical sensors for genomics and proteomics Interferon-gamma, but not interferon-alpha, induces SOCS 3 expression in human melanoma cell lines The influence of carvedilol on the production of reactive oxygen and nitrogen species by phagocytes Ultrafiltered pig leukocyte extract (UPLE, IMUNOR) potentiates hematopoiesis-stimulating effects of G-CSF in vitro and improves the outcome of treatment of hematopoietic radiation damage in mice with G-CSF DNA hybridization on membrane-modified carbon electrodes Use of DNA repair enzymes in electrochemical detection of damage to DNA bases in vitro and in cells Telomere repeat binding protein variants show distinct kinetics and energetic nature of DNA-protein interaction Fate of telomere binding proteins after the loss of telomeres HMGB1 associates with TERT and stimulates telomerase activity In vivo localisation of Arabidopsis thaliana Myb-like proteins Mapping of interaction domains of putative plant telomere preteins Electrochemical Renewal of Stationary Mercury Drop or Meniscus Electrodes 8-Oxoguanine in a quadruplex of the human telomere DNA sequence Geometrical and electronic structure variability of the sugar-phosphate backbone in nucleic acids General Base Catalysis for Cleavage by the Active-Site Cytosine of the Hepatitis Delta Virus Ribozyme: QM/MM Calculations Establish Chemical Feasibility Balance of Attraction and Repulsion in Nucleic-Acid Base Stacking: CCSD(T)/Complete-Basis-Set-Limit Calculations on Uracil Dimer and a Comparison with the Force-Field Description Health Status of the Nase (Chondrostoma nasus) in Breeding Farms from the Jihlava River Basin Aminophenyl- and nitrophenyl-labeled nucleoside triphosphates. Synthesis, enzymatic incorporation and electrochemical detection Nature and magnitude of aromatic stacking of nucleic acid bases Spatio-temporal changes of SDF1 and its CXCR4 receptor in the dorsal root ganglia following unilateral sciatic injury as a model of neuropathic pain Satellite glial cells express IL-6 and corresponding signal-transducing receptors in the dorsal root ganglia of rat neuropathic pain model Expression of RAN, ZHX-2, and CHC1L genes in multiple myeloma patients and in myeloma cell lines treated with HDAC and Dnmts inhibitors. Comparative analysis of proteomic changes in contrasting flax cultivars upon cadmium exposure Histone H2AX-dependent GABA(A) receptor regulation of stem cell proliferation Differentiation of human embryonic stem cells induces condensation of chromosome territories and formation of heterochromatin protein 1 foci Synthesis, biophysical studies, and antiproliferative activity of platinum(II) complexes having 1,2-bis(aminomethyl)carbobicyclic ligands

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