About: Spatio-temporal changes of SDF1 and its CXCR4 receptor in the dorsal root ganglia following unilateral sciatic injury as a model of neuropathic pain

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About: Spatio-temporal changes of SDF1 and its CXCR4 receptor in the dorsal root ganglia following unilateral sciatic injury as a model of neuropathic pain Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	There is a growing evidence that chemokines and their receptors play a role in inducing and maintaining neuropathic pain. In the present study, unilateral chronic constriction injury (CCI) of rat sciatic nerve was used to investigate changes for stromal derived factor-1 (SDF1) and its CXCR4 receptor in lumbal and cervical dorsal root ganglia from both sides of naive, operated and sham-operated rats. All operated rats displayed mechanical allodynia and thermal hyperalgesia in hind paws ipsilateral to CCI, but forepaws exhibited only temporal changes of sensitivity. Immunofluorescence staining and Western blot analysis confirmed bilateral alterations of SDF1 and CXCR4 proteins in all examined DRG. No attenuation of mechanical allodynia, but reversed thermal hyperalgesia, in ipsi- and contralateral hind paws was found in CCI-operated rats after i.p. administration of CXCR4 antagonist. These results indicate that SDF1/CXCR4 changes are not limited to DRG associated with injured nerve. There is a growing evidence that chemokines and their receptors play a role in inducing and maintaining neuropathic pain. In the present study, unilateral chronic constriction injury (CCI) of rat sciatic nerve was used to investigate changes for stromal derived factor-1 (SDF1) and its CXCR4 receptor in lumbal and cervical dorsal root ganglia from both sides of naive, operated and sham-operated rats. All operated rats displayed mechanical allodynia and thermal hyperalgesia in hind paws ipsilateral to CCI, but forepaws exhibited only temporal changes of sensitivity. Immunofluorescence staining and Western blot analysis confirmed bilateral alterations of SDF1 and CXCR4 proteins in all examined DRG. No attenuation of mechanical allodynia, but reversed thermal hyperalgesia, in ipsi- and contralateral hind paws was found in CCI-operated rats after i.p. administration of CXCR4 antagonist. These results indicate that SDF1/CXCR4 changes are not limited to DRG associated with injured nerve. (en)
Title	Spatio-temporal changes of SDF1 and its CXCR4 receptor in the dorsal root ganglia following unilateral sciatic injury as a model of neuropathic pain Spatio-temporal changes of SDF1 and its CXCR4 receptor in the dorsal root ganglia following unilateral sciatic injury as a model of neuropathic pain (en)
skos:prefLabel	Spatio-temporal changes of SDF1 and its CXCR4 receptor in the dorsal root ganglia following unilateral sciatic injury as a model of neuropathic pain Spatio-temporal changes of SDF1 and its CXCR4 receptor in the dorsal root ganglia following unilateral sciatic injury as a model of neuropathic pain (en)
skos:notation	RIV/00216224:14110/10:00043475!RIV11-GA0-14110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA309/07/0121), Z(AV0Z50040507), Z(AV0Z50040702), Z(MSM0021622404)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Hradilová Svíženská, Ivana Brázda, Václav Dubový, Petr Klusáková, Ilona
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	288987
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/10:00043475
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Chemokine; Satellite glial cells; Chronic constriction injury (en)
http://linked.open.../riv/klicoveSlovo	Chemokine Chronic constriction injury Satellite glial cells
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[2A027C7ECB04]
http://linked.open...i/riv/nazevZdroje	Histochemistry and Cell Biology
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Spatio-temporal changes of cytokines in the dorsal root ganglia of experimental neuropathic pain models induced by unilateral nerve injury
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	133/2010
http://linked.open...iv/tvurceVysledku	Brázda, Václav Dubový, Petr Hradilová Svíženská, Ivana Klusáková, Ilona
http://linked.open...ain/vavai/riv/wos	000274399800006
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions The Internal Organisation and Neurobiological Mechanisms of Functional CNS Systems under Normal and Pathological Conditions
issn	0948-6143
number of pages	15 (xsd:int)
http://localhost/t...ganizacniJednotka	14110
is http://linked.open...avai/riv/vysledek of	Spatio-temporal changes of SDF1 and its CXCR4 receptor in the dorsal root ganglia following unilateral sciatic injury as a model of neuropathic pain Spatio-temporal changes of SDF1 and its CXCR4 receptor in the dorsal root ganglia following unilateral sciatic injury as a model of neuropathic pain Spatio-temporal changes of SDF1 and its CXCR4 receptor in the dorsal root ganglia following unilateral sciatic injury as a model of neuropathic pain

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