About: Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions

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About: Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions Goto Sponge NotDistinct Permalink

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rdf:type	http://linked.opendata.cz/ontology/domain/vavai/Zamer
Description	The research will be focused on study of molecular and spatial structure of genome, effects of epigenetic variations on arrangement of the genome in cell nucleus, dynamics of genome, epigenome and proteome during cell cycle, differentiation and malignant transformation of the cell. We will investigate mechanisms of epigenetic control of gene expression and role of the epigenome in heredity of transcriptional profile and its changes in differentiation, ontogenesis and phylogeny. Attention will be paid to detailed study of the impacts of living systems exposure to external factors (physical and/or chemical) on genome, epigenome, transcriptome, proteome and metabolome levels. Efforts aimed to expansion of methodological background of the science disciplines involved, including development of novel experimental approaches, represent important strand of the proposed research. Results of the research plan will find applications especially in biomedicine, biotechnologies and ekotoxicology. (en) Výzkum bude zaměřen na studium molekulární a prostorové struktury genomu, vlivu epigenetických variací na uspořádání genomu v jádře buňky, dynamiky genomu, epigenomu a proteomu v průběhu buněčného cyklu, diferenciace a zhoubné transformace buňky. Budou zkoumány mechanismy epigenetické regulace genové exprese a úloha epigenomu v dědičnosti transkripčního profilu a jeho změnách při diferenciaci, v ontogenezi a vnějším faktorům (fyzikálním a chemickým) na úrovni genomu, epigenomu, transkriptomu, proteomu a metabolomu. Důležitou součástí navrhovaného výzkumu bude rozšiřování metodologické výbavy zahrnutých vědních oborů, včetně vývoje a zavádění nových experimentálních přístupů a analytických nástrojů. Výsledky řešení výzkumného záměru naleznou uplatnění zejména v biomedicíně, zemědělských biotechnologiích a ekotoxikologii.
Title	Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions (en) Genom a epigenom: 1D a 3D struktura, dynamika, interakce s proteiny a funkce
http://linked.open...kovaStatniPodpora	http://linked.opendata.cz/resource/domain/vavai/zamer/AV0Z50040702/celkovaStatniPodpora
http://linked.open...ez/celkoveNaklady	http://linked.opendata.cz/resource/domain/vavai/zamer/AV0Z50040702/celkoveNaklady
http://linked.open...datumDodatniDoRIV	2014-06-17 (xsd:date)
http://linked.open...vavai/cez/dodavka	http://linked.opendata.cz/resource/domain/vavai/dodavka/CEZ14-AV0-U%2F01%3A1
http://linked.open...ez/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...in/vavai/cez/faze	33175443
http://linked.open...ai/cez/hlavniObor	BO - Biofyzika
http://linked.open...vai/cez/hodnoceni	V - Vynikající výsledky (s mezinárodním významem apod.). Zároveň byly splněny cíle a předpokládané výsledky uvedené ve smlouvě / rozhodnutí o poskytnutí podpory.
http://linked.open.../cez/kategorieVaV	ZV - Základní výzkum
http://linked.open.../cez/klicovaSlova	genome; epigenome; proteome; dynamics of biomolecules; DNA-protein interactions; posttranslational modifications; gene expression; DNA damage and repair; cellular signaling; redox equilibrium; carcinogenesis; phylogeny; biosensors; imaging techniques (en)
http://linked.open...cez/partnerHlavni	Biofyzikální ústav AV ČR, v.v.i.
http://linked.open...z/poceVysledkuRIV	722 (xsd:int)
http://linked.open...inujicichPrijemcu	0 (xsd:int)
http://linked.open...cez/pocetPrijemcu	1 (xsd:int)
http://linked.open...ocetSpoluPrijemcu	0 (xsd:int)
http://linked.open...enychVysledkuVRIV	722 (xsd:int)
http://linked.open...lneniVMinulemRoce	2013-11-29 (xsd:date)
http://linked.open.../prideleniPodpory	http://linked.opendata.cz/resource/domain/vavai/cez/prideleniPodpory/AV0Z50040702
http://linked.open.../vavai/cez/resort	Academy of Sciences of the Czech Republic
http://linked.open...iciPoslednihoRoku	2013
http://linked.open...atUdajeProjZameru	2014
http://linked.open...usZobrazovaneFaze	DUU
http://linked.open...ez/ukonceniReseni	2013-12-31 (xsd:date)
http://linked.open.../cez/vedlejsiObor	EB - Genetika a molekulární biologie
http://linked.open...ez/zahajeniReseni	2007-01-01 (xsd:date)
http://linked.open...n/vavai/cez/zamer	Z - Výzkumný záměr financovaný ze státního rozpočtu
http://linked.open...sledkuDodavatelem	Výzkumný záměr byl orientován na genom, jeho strukturu, dynamiku a funkci a epigenom. V rámci jeho řešení byla nalezena a publikována řada nových, originálních výsledků s velkým mezinárodním ohlasem (publikace dedikované VZ byl doposud citovány 3350x). VZ přispěl k posílení excelence ve výzkumu genomu a epigenomu v ČR, spolupráce v dané oblasti a výchově nových vědeckých pracovníků. (cs) The project has been oriented to the research of genome, its structure, dynamics and function and epigenome. It has been found a number of new and original results with marked international impact . The project contributed to the excellence of research of genome and epigenome in the Czech Republic, collaboration in this field of science and education of new scientists. (en)
http://linked.open...cez/zivotniCyklus	ZBBBBBKU
is http://linked.open...n/vavai/riv/zamer of	Electrochemical behaviour of 2,4-dinitrophenylhydrazi(o)ne asmulti-redox centre DNA label at mercury meniscus modified silversolid amalgam electrode Fate of telomere binding proteins after the loss of telomeres Electrochemical Renewal of Stationary Mercury Drop or Meniscus Electrodes Thermodynamics of translesion synthesis across a major DNA adduct of antitumor oxaliplatin: Differential scanning calorimetric study The thermodynamics of translesion DNA synthesis past major adducts of enantiomeric analogues of antitumor cisplatin TGF-beta1 signaling plays a dominant role in the crosstalk between TGF-beta1 and the aryl hydrocarbon receptor ligand in prostate epithelial cells Trajectories and nuclear arrangement of PML bodies are influenced by A-type lamin deficiency Tumor-specific histone signature and DNA methylation in multiple myeloma and leukemia cells Three TERT genes in Nicotiana tabacum Thermodynamic and mechanistic insights into translesion DNA synthesis catalyzed by Y-family DNA polymerase across a bulky double-base lesion of an antitumor platinum drug Voltammetric determination of Os(VI)-modified oligo-saccharides at nanomolar level A polymerase chain reaction-based approach for evaluation of telomere-associated sequences and interstitial telomeric sequences 8-Oxoguanine in a quadruplex of the human telomere DNA sequence 3,6-Bis(3-alkylguanidino)acridines as DNA-intercalating antitumor agents Activation of trans geometry in bifunctional mononuclear platinum complexes by a non-bulky methylamine ligand A Broad Phylogenetic Survey Unveils the Diversity and Evolution of Telomeres in Eukaryotes Aryl Hydrocarbon Receptor Negatively Regulates Expression of the Plakoglobin Gene (Jup) Benchmark quantum-chemical calculations on a complete set of rotameric families of the DNA sugar-phosphate backbone and their comparison with modern density functional theory Aryl hydrocarbon receptor-mediated disruption of contact inhibition is associated with connexin43 downregulation and inhibition of gap junctional intercellular communication Asymmetric dimethylarginine regulates the lipopolysaccharide-induced nitric oxide production in macrophages by suppressing the activation of NF-kappaB and iNOS expression Crystal structures of B-DNA dodecamer containing the epigenetic modifications 5-hydroxymethylcytosine or 5-methylcytosine Contrasting Patterns of Transposable Element and Satellite Distribution on Sex Chromosomes (XY1Y2) in the Dioecious Plant Rumex acetosa Enzymatic activity and catalytic hydrogen evolution in reduced and oxidized urease at mercury surfaces Epigenetic aspects of HP1 exchange kinetics in apoptotic chromatin Electrochemistry of closo-dodecaborate dianion and its simple exo-skeletal derivatives at carbon electrodes in aqueous phosphate buffers. Effect of Guanine to Inosine Substitution on Stability of Canonical DNA and RNA Duplexes: Molecular Dynamics Thermodynamics Integration Study Effects of Pectic Polysaccharides Isolated from Leek on the Production of Reactive Oxygen and Nitrogen Species by Phagocytes Insight into the toxic effects of cis-dichloridoplatinum(II) complexes containing 7-azaindole halogeno derivatives in tumor cells Os(VI)bipy-based electrochemical assay for detection of specific microRNAs as potential cancer biomarkers Proteome and metabolome profiling of cytokinin action in Arabidopsis identifies distinct but also similar responses to cytokinin down- and up-regulation Geometrical and electronic structure variability of the sugar-phosphate backbone in nucleic acids General Base Catalysis for Cleavage by the Active-Site Cytosine of the Hepatitis Delta Virus Ribozyme: QM/MM Calculations Establish Chemical Feasibility Balance of Attraction and Repulsion in Nucleic-Acid Base Stacking: CCSD(T)/Complete-Basis-Set-Limit Calculations on Uracil Dimer and a Comparison with the Force-Field Description Health Status of the Nase (Chondrostoma nasus) in Breeding Farms from the Jihlava River Basin Nature and magnitude of aromatic stacking of nucleic acid bases Spatio-temporal changes of SDF1 and its CXCR4 receptor in the dorsal root ganglia following unilateral sciatic injury as a model of neuropathic pain Satellite glial cells express IL-6 and corresponding signal-transducing receptors in the dorsal root ganglia of rat neuropathic pain model Expression of RAN, ZHX-2, and CHC1L genes in multiple myeloma patients and in myeloma cell lines treated with HDAC and Dnmts inhibitors. Comparative analysis of proteomic changes in contrasting flax cultivars upon cadmium exposure Histone H2AX-dependent GABA(A) receptor regulation of stem cell proliferation Differentiation of human embryonic stem cells induces condensation of chromosome territories and formation of heterochromatin protein 1 foci Synthesis, biophysical studies, and antiproliferative activity of platinum(II) complexes having 1,2-bis(aminomethyl)carbobicyclic ligands Response of normal and colon cancer epithelial cells to TNF-family apoptotic inducers Amide-based prodrugs of spermidine-bridged dinuclear platinum. Synthesis, DNA binding, and biological activity Enzyme-linked electrochemical detection of PCR-amplified nucleotide sequences using disposable screen-printed sensors. Applications in gene expression monitoring Comparative investigations of the influence of H1-antihistamines on the generation of reactive oxygen species by phagocytes Estrogenic, antiestrogenic, and dioxin-like activities in human male serum samples from Eastern Slovakia Acquired genomic aberrations associated with methotrexate resistance vary with background genomic instability Cytotoxicity, mutagenicity, cellular uptake, DNA and glutathione interactions of lipophilic trans-platinum complexes tethered to 1-adamantylamine Rottlerin inhibits the nuclear factor kappaB/cyclin-D1 cascade in MCF-7 breast cancer cells TCDD deregulates contact inhibition in rat liver oval cells via Ah receptor, JunD and cyclin A Multiple defects in negative regulation of PKB/Akt pathway sensitize cancer cells to anti proliferative effect of non steroidal anti inflammatory drugs Origin and Evolution of Telomeres Chromosome landmarks as tools to study the genome of Arabidopsis thaliana Arabidopsis SMG7 protein is required for exit from meiosis The ups and downs of genome size evolution in polyploid species of Nicotiana (Solanaceae) Evolution of rDNA in Nicotiana allopolyploids: A potential link between rDNa homogenization and epigenetics Platinum(IV) complex LA-12 perturbes cell cycle and causes apoptosis in human colorectal carcinoma cell lines DNA binding of dinuclear iron(II) metallosupramolecular cylinders. DNA unwinding and sequence preference Využití konfokální mikroskopie v buněčné biologii Photoprotective effects of glucomannan isolated from candida utilis DNA interactions of monofunctional organometallic osmium(II) antitumor complexes in cell-free media Meloxicam, an inhibitor of cyclooxygenase-2, increases the level of serum G-CSF and might be usable as an auxiliary means in G-CSF therapy Plasma levels of myeloperoxidase are not elevated in patients with stable coronary artery disease Trans-generation inheritance of methylation patterns in a tobacco transgene following a post-transcriptional silencing event Genus Silene (Caryophyllaceae) - Evolutionary Diversification and Sex Chromosome Formation

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