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| rdf:type
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| Description
| - Differences in lipid metabolism of tumor and normal tissues suggest a distinct response to available lipid compounds. In this study, the in vitro effects of five types of commercial parenteral lipid emulsions were investigated on human cell lines derived from normal fetal colon (FHC) or colon adenocarcinoma (HT-29). Changes of the cellular lipid fatty acid content, cell oxidative response, and the cell growth and death rates were evaluated after 48 h. No effects of any type of emulsions were detected on cell proliferation and viability. Compared to the controls, supplementation with lipid emulsions resulted in a multiple increase of linoleic and linolenic acids in total cell lipids, but the content of arachidonic, eicosapentaenoic, and docosahexaenoic acids decreased particularly in HT-29 cells.
- Differences in lipid metabolism of tumor and normal tissues suggest a distinct response to available lipid compounds. In this study, the in vitro effects of five types of commercial parenteral lipid emulsions were investigated on human cell lines derived from normal fetal colon (FHC) or colon adenocarcinoma (HT-29). Changes of the cellular lipid fatty acid content, cell oxidative response, and the cell growth and death rates were evaluated after 48 h. No effects of any type of emulsions were detected on cell proliferation and viability. Compared to the controls, supplementation with lipid emulsions resulted in a multiple increase of linoleic and linolenic acids in total cell lipids, but the content of arachidonic, eicosapentaenoic, and docosahexaenoic acids decreased particularly in HT-29 cells. (en)
- Byly zkoumány in vitro účinky pěti typů komerčních parenterálních lipidových emulzí na lidské buněčné linie odvozené z normálního fetálního kolonu (FHC) nebo adenokarcinomu kolonu (HT-29). Po 48 h byly hodnoceny změny obsahu mastných kyselin v buněčných lipidech, oxidativní metabolismus a buněčný růst a smrt. Ve srovnání s kontrolou způsobilo přidání emulzí vzrůst obsahu zejména linoleové kyseliny. Buněčná proliferace a viabilita nebyly ovlivněny. Koncentrace emulzí, která neovlivnila buňky HT-29, zvýšila množství apoptických buněk u linie FHC pravděpodobně díky oxidativnímu stresu, který byl redukován působením troloxu. Výsledky ukazují, že odpověď střevních buněk různého původu na působení lipidových emulzí může být odlišná. (cs)
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| Title
| - The effects of parenteral lipid emulsions on cancer and normal human colon epithelial cells in vitro
- The effects of parenteral lipid emulsions on cancer and normal human colon epithelial cells in vitro (en)
- Účinky parenterálních lipidových emulzí na nádorové a normální lidské epiteliální buňky kolonu in vitro (cs)
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| skos:prefLabel
| - The effects of parenteral lipid emulsions on cancer and normal human colon epithelial cells in vitro
- The effects of parenteral lipid emulsions on cancer and normal human colon epithelial cells in vitro (en)
- Účinky parenterálních lipidových emulzí na nádorové a normální lidské epiteliální buňky kolonu in vitro (cs)
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| skos:notation
| - RIV/68081707:_____/05:00020904!RIV06-AV0-68081707
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| http://linked.open.../vavai/riv/strany
| |
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - P(FD-K/033), P(GA524/03/0766), P(GA524/04/0895), P(GA525/01/0419), P(IBS5004009), Z(AV0Z50040507)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/68081707:_____/05:00020904
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| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - fat emulsion; reactive oxygen; lipid peroxidation (en)
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| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| |
| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| |
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Hofmanová, Jiřina
- Hyšpler, R.
- Kozubík, Alois
- Vaculová, Alena
- Zadák, Z.
- Netíková, Jaromíra
- Žďánský, P.
- Mikeska, J.
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| http://linked.open...n/vavai/riv/zamer
| |
| issn
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| number of pages
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| is http://linked.open...avai/riv/vysledek
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