| Attributes | Values |
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| rdf:type
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| Description
| - Ohnutí, rozvinutí a další strukturní změny v DNA vyvolané vazbou enantiomerů platnatých komplexů obsahujících ligand ahaz (ahaz=3-aminohexahydroazepin) byly studovány s využitím krátkých duplexů DNA 20-23 párů bází dlouhých obsahujících vazebná místa TGGT a CGGA pro rozlišení aduktů proteiny obsahujícími doménu HMG. Strukturní studie spolu s počítačovým modelováním odhalily výrazné odlišnosti v lokálních distorsích ve vazebných místech obsahujících GG sekvence a ukazují, že interakce mezi methylovými skupinami a ligandem ahaz pravděpodobně inhibují ohnutí DNA v TGGT sekvenci. (cs)
- The bending, unwinding, and structural changes in DNA caused by the binding of each of the enantiomers of the platinum(II) complexes of the ahaz ligand (R- and S-[PtCl2(ahaz)], ahaz 3-aminohexahydroazepine) have been studied using 20-23 bp oligonucleotides containing TGGT and CGGA-binding sites as has the recognition of the adducts by HMG domain proteins. The domain A of HMGB1 (HMGB1a protein) binds to the adduct formed by the R enantiomer at the CGGA sequence with a similar high affinity as it does to the adduct of antitumor cisplatin, and to the adduct formed by the S enantiomer with a slightly lower affinity. In contrast, HMGB1a binds much more weakly to the ahaz adducts than to the cisplatin adducts formed at the TGGT sequence, with the binding to the adduct formed by the R enantiomer being weakest. Each enantiomer and cisplatin cause unwinding of both sequences that is in the narrow range, 19-22 degrees.
- The bending, unwinding, and structural changes in DNA caused by the binding of each of the enantiomers of the platinum(II) complexes of the ahaz ligand (R- and S-[PtCl2(ahaz)], ahaz 3-aminohexahydroazepine) have been studied using 20-23 bp oligonucleotides containing TGGT and CGGA-binding sites as has the recognition of the adducts by HMG domain proteins. The domain A of HMGB1 (HMGB1a protein) binds to the adduct formed by the R enantiomer at the CGGA sequence with a similar high affinity as it does to the adduct of antitumor cisplatin, and to the adduct formed by the S enantiomer with a slightly lower affinity. In contrast, HMGB1a binds much more weakly to the ahaz adducts than to the cisplatin adducts formed at the TGGT sequence, with the binding to the adduct formed by the R enantiomer being weakest. Each enantiomer and cisplatin cause unwinding of both sequences that is in the narrow range, 19-22 degrees. (en)
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| Title
| - DNA adducts of the enantiomers of the Pt(II) complexes of the ahaz ligand (ahaz=3-aminohexahydroazepine) and recognition of these adducts by HMG domain proteins
- Adukty vytvořené v DNA enantiomerními platnatými komplexy obsahujícími ligand ahaz (ahaz=3-aminohexahydroazepin) a rozlišení těchto aduktů proteiny obsahujícími doménu HMG (cs)
- DNA adducts of the enantiomers of the Pt(II) complexes of the ahaz ligand (ahaz=3-aminohexahydroazepine) and recognition of these adducts by HMG domain proteins (en)
|
| skos:prefLabel
| - DNA adducts of the enantiomers of the Pt(II) complexes of the ahaz ligand (ahaz=3-aminohexahydroazepine) and recognition of these adducts by HMG domain proteins
- Adukty vytvořené v DNA enantiomerními platnatými komplexy obsahujícími ligand ahaz (ahaz=3-aminohexahydroazepin) a rozlišení těchto aduktů proteiny obsahujícími doménu HMG (cs)
- DNA adducts of the enantiomers of the Pt(II) complexes of the ahaz ligand (ahaz=3-aminohexahydroazepine) and recognition of these adducts by HMG domain proteins (en)
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| skos:notation
| - RIV/68081707:_____/05:00001321!RIV06-AV0-68081707
|
| http://linked.open.../vavai/riv/strany
| |
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - P(GA305/05/2030), P(IAA5004101), P(IBS5004107), Z(AV0Z50040507)
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| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
| |
| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/68081707:_____/05:00001321
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - cisplatin; anticancer; enantiomers (en)
|
| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
|
| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| - Biochemical and Biophysical Research Communications
|
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Brabec, Viktor
- Malina, Jaroslav
- Vojtíšková, Marie
- Diakos, Connie I.
- Hambley, Trevor W.
|
| http://linked.open...n/vavai/riv/zamer
| |
| issn
| |
| number of pages
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| is http://linked.open...avai/riv/vysledek
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