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Description
| - The limitations associated with the clinical use of transition-metal compounds in cancer chemotherapy prompted a search for more effective and less toxic alternativi metal-based antitumor agents. This effort led to the synthesis of thousands of metal-based complexes which were evaluated as antitumor agents and tested in cancer cells, but only several reached clinical trials and most of them have already been rejected. Therefore, the search for new metal-based antitumor drugs and their clinical testing continues to yield more significant improvements in cancer treatment than during last three decades. Broadening the chemotherapeutic arsenal depends on understanding existing agents with a view toward developing new modes of attack. In addition, it is generally accepted that the anticancer activity of several transition metal-based coordination complexes arises from their ability to damage DNA. Hence, the overall significance of this proposal is to ask the fundamental question - can modifícation (en)
- Omezení související s klinickým využitím sloučenin přechodových kovů v chemoterapii rakoviny byla podnětem pro vyhledávání efektivnějších a méně toxických alternativních cytostatik odvozených od komplexů kovů. Toto úsilí již vedlo k syntéze několika tisíců sloučenin této třídy, které sice vykazovaly protinádorovou účinnost a byly testovány v nádorových buňkách, avšak pouze několik z nich bylo posléze klinicky testováno a většina z nich již byla odmítnuta. Proto vyhledávání a výzkum nových cytostatikodvozených od komplexů kovů a jejich klinické testování pokračuje s cílem dosáhnout výraznějšího pokroku v léčení rakoviny. Rozšíření možností pro chemoterapii závisí na porozumění biologickým účinkům léčiv již využívaných v klinické praxi s výhledem nalézt nové rysy jejich biologického působení. Kromě toho je všeobecně uznávanou skutečností, že protinádorová účinnost řady koordinačních komplexů přechodových kovů je podmíněna jejich schopností poškodit DNA. Obecným cílem tohoto navrhuje tedy
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Title
| - New approaches to cancer chemotherapy by metal-based drugs (en)
- Nové přístupy k chemoterapii rakoviny látkami odvozenými od sloučenin kovů
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skos:notation
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http://linked.open...avai/cep/aktivita
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http://linked.open...kovaStatniPodpora
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http://linked.open...ep/celkoveNaklady
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http://linked.open...datumDodatniDoRIV
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http://linked.open...i/cep/druhSouteze
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http://linked.open...ep/duvernostUdaju
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http://linked.open.../cep/fazeProjektu
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http://linked.open...ai/cep/hlavniObor
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http://linked.open...hodnoceniProjektu
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http://linked.open...vai/cep/kategorie
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http://linked.open.../cep/klicovaSlova
| - antitumor drugs; transition metals; ultrasound; repair (en)
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http://linked.open...ep/partnetrHlavni
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http://linked.open...inujicichPrijemcu
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http://linked.open...cep/pocetPrijemcu
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http://linked.open...ocetSpoluPrijemcu
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http://linked.open.../pocetVysledkuRIV
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http://linked.open...enychVysledkuVRIV
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http://linked.open...lneniVMinulemRoce
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http://linked.open.../prideleniPodpory
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http://linked.open...iciPoslednihoRoku
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http://linked.open...atUdajeProjZameru
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http://linked.open.../vavai/cep/soutez
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http://linked.open...usZobrazovaneFaze
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http://linked.open...ai/cep/typPojektu
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http://linked.open...ep/ukonceniReseni
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http://linked.open.../cep/vedlejsiObor
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http://linked.open...ep/zahajeniReseni
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http://linked.open...jektu+dodavatelem
| - Protinádorová účinnost řady koordinačních komplexů přechodových kovů je podmíněna jejich schopností poškodit DNA. Výsledky získané při řešení tohoto projektu přesvědčivě ukazují, že modifikace vazby sloučenin odvozených od komplexů kovů, zejména platiny (cs)
- The anticancer activity of several transition metal-based coordination complexes arises from their ability to damage DNA. The results of this project demonstrate convincingly that modification of DNA binding of metal-based compounds, namely platinum and (en)
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http://linked.open...tniCyklusProjektu
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http://linked.open.../cep/klicoveSlovo
| - transition metals
- ultrasound
- antitumor drugs
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is http://linked.open...vavai/riv/projekt
of | - DNA adducts of the enantiomers of the Pt(II) complexes of the ahaz ligand (ahaz=3-aminohexahydroazepine) and recognition of these adducts by HMG domain proteins
- Chiral differentiation of DNA adducts formed by enantiomeric analogues of antitumor cisplatin is sequence-dependent
- Modifications of DNA by platinum complexes. Relation to resistance of tumors to platinum antitumor drugs
- Metal compounds in cancer chemotherapy
- Changes in the diameters of nuclear pore complexes after application the therapeutic ultrasound
- Effects of therapeutic ultrasound on the nuclear envelope and nuclear pore complexes
- Biological effects of combined ultrasound and cisplatin treatment on ovarian carcinoma cells
- Synthesis, biophysical studies, and antiproliferative activity of platinum(II) complexes having 1,2-bis(aminomethyl)carbobicyclic ligands
- Amide-based prodrugs of spermidine-bridged dinuclear platinum. Synthesis, DNA binding, and biological activity
- Cytotoxicity, mutagenicity, cellular uptake, DNA and glutathione interactions of lipophilic trans-platinum complexes tethered to 1-adamantylamine
- Unique properties of DNA interstrand cross-links of antitumor oxaliplatin and the effect of chirality of the carrier ligand
- Tröger's base scaffold in racemic and chiral fashion as a spacer for bisdistamycin formation. Synthesis and DNA binding study
- Conformation, protein recognition and repair of DNA interstrand and intrastrand cross-links of antitumor trans-[PtCl2(NH3)(thiazole)]
- Structural characterization and DNA interactions of new cytotoxic transplatin analogues containing one planar and one nonplanar heterocyclic amine ligand.
- Deoxyribonuclease I footprinting reveals different DNA binding modes of bifunctional platinum complexes
- Cationic nonsymmetric transplatinum complexes with piperidinopiperidine ligands. Preparation, characterization, in vitro cytotoxicity, in vivo toxicity, and anticancer efficacy studies
- Structural characterization, DNA interactions, and cytotoxicity of new transplatin analogues containing one aliphatic and one planar heterocyclic amine ligand
- Thermodynamic properties of damaged DNA and its recognition by xeroderma pigmentosum group A protein and replication protein A
- Molecular aspects of antitumor effects of a new platinum(IV) drug
- DNA binding mode of ruthenium complexes and relationship to tumor cell toxicity
- Recogntiton of DNA modified by trans-[PtCl2NHš(4-hydroxymethylpyridine)] by tumor suppressor protein p53 and character of DNA adducts of this cytotoxic complex
- Transplatin is cytotoxic when photoactivated: Enhanced formation of DNA cross-links
- High-throughput screening identifies novel agents eliciting hypersensitivity in Fanconi pathway-deficient cancer cells
- 1,2-GG intrastrand cross-link of antitumor dinuclear bifunctional platinum compound with spermidine linker inhibits DNA polymerization more effectively than the cross-link of conventional cisplatin
- NMR analysis of duplex d(CGCGATCGCG)2 modified by lambda- and delta-[Ru(bpy)2(m-GHK)]Cl2 and DNA photocleavage study
- Mechanism of the formation of DNA-protein cross-links by antitumor cisplatin
- DNA interactions of new cytotoxic tetrafunctional dinuclear platinum complex trans,trans-[{PtCl2(NH3)}2(piperazine)]
- Dual triggering of DNA binding and fluorescence via photoactivation of a dinuclear ruthenium(II) arene complex
- Raman spectroscopy of DNA modified by intrastrand cross-links of antitumor cisplatin
- Reaction of Zn7metallothionein with cis- and trans-[Pt(N-donor)2Cl2] anticancer complexes: trans-PtII complexes retain their N-donor ligands
- Bifunctional amine-tethered ruthenium(II) arene complexes form monofunctional adducts on DNA
- Conformation of DNA GG intrastrand cross-link of antitumor oxaliplatin and its enantiomeric analog
- Biochemical studies of the thermal effects on DNA modifications by the antitumor cisplatin and their repair
- A potent cytotoxic photoactivated platinum complex
- The combined effect of ultrasound exposure and cisplatin on human ovarian carcinoma cells A2780
- Recognition of DNA three-way junctions by metallosupramolecular cylinders: Gel electrophoresis studies
- Interactions of platinum complexes containing cationic, bicyclic, nonplanar piperidinopiperidine ligands with biological nucleophiles
- Changes in nuclear envelope structure after exposure to ultrasound
- Changes in the distribution of intra-membrane proteins after insonation of the plasma membrane
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is http://linked.open...vavai/cep/projekt
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