About: Cationic nonsymmetric transplatinum complexes with piperidinopiperidine ligands. Preparation, characterization, in vitro cytotoxicity, in vivo toxicity, and anticancer efficacy studies

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About: Cationic nonsymmetric transplatinum complexes with piperidinopiperidine ligands. Preparation, characterization, in vitro cytotoxicity, in vivo toxicity, and anticancer efficacy studies Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Byla připravena a charakterizována série komplexů obecného vzorce trans-[PtCl2(Am)(pip-pip)].HCl, kde pip-pip je 4-piperidinopiperidin a Am is NH3, methylamin, dimethylamin, n-propylamin, isopropylamin, n-butylamin nebo cyclohexylamin a byly vyhodnoceny jejich cytotoxické vlastnosti v ovariálních a střevních nádorových buňkách. (cs) A series of complexes of the general formula trans-[PtCl2(Am)(pip-pip)].HCl where pip-pip is 4-piperidinopiperidine and Am is NH3, methylamine, dimethylamine, n-propylamine, isopropylamine, n-butylamine, or cyclohexylamine were prepared and characterized, and their cytotoxic properties against ovarian and colon cancer cells were evaluated. A series of complexes of the general formula trans-[PtCl2(Am)(pip-pip)].HCl where pip-pip is 4-piperidinopiperidine and Am is NH3, methylamine, dimethylamine, n-propylamine, isopropylamine, n-butylamine, or cyclohexylamine were prepared and characterized, and their cytotoxic properties against ovarian and colon cancer cells were evaluated. (en)
Title	Cationic nonsymmetric transplatinum complexes with piperidinopiperidine ligands. Preparation, characterization, in vitro cytotoxicity, in vivo toxicity, and anticancer efficacy studies Kationtové nesymetrické komplexy transplatiny s piperidinopiperidinovými ligandy. Příprava, charakterizace, cytotoxicita in vitro, toxicita in vivo a protinádorová účinnost (cs) Cationic nonsymmetric transplatinum complexes with piperidinopiperidine ligands. Preparation, characterization, in vitro cytotoxicity, in vivo toxicity, and anticancer efficacy studies (en)
skos:prefLabel	Cationic nonsymmetric transplatinum complexes with piperidinopiperidine ligands. Preparation, characterization, in vitro cytotoxicity, in vivo toxicity, and anticancer efficacy studies Kationtové nesymetrické komplexy transplatiny s piperidinopiperidinovými ligandy. Příprava, charakterizace, cytotoxicita in vitro, toxicita in vivo a protinádorová účinnost (cs) Cationic nonsymmetric transplatinum complexes with piperidinopiperidine ligands. Preparation, characterization, in vitro cytotoxicity, in vivo toxicity, and anticancer efficacy studies (en)
skos:notation	RIV/68081707:_____/06:00040265!RIV07-AV0-68081707
http://linked.open.../vavai/riv/strany	4665;4673
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1QS500040581), P(GA305/05/2030), P(NR8562), Z(AV0Z50040507)
http://linked.open...iv/cisloPeriodika	15
http://linked.open...vai/riv/dodaniDat	2007
http://linked.open...aciTvurceVysledku	Brabec, Viktor Kašpárková, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	467882
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/06:00040265
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	transplatinum complexes; piperidinopiperidine ligands; ligands (en)
http://linked.open.../riv/klicoveSlovo	ligands piperidinopiperidine ligands transplatinum complexes
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[3973AF2EE88E]
http://linked.open...i/riv/nazevZdroje	Journal of Medicinal Chemistry
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Metallodrugs, design and mechansim of action New approaches to cancer chemotherapy by metal-based drugs Inhibition of telomerase by transition metal complexes. A new concept of antitumor drug design
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	49
http://linked.open...iv/tvurceVysledku	Brabec, Viktor Kašpárková, Jana Perez, J. M. Gibson, D. Najajreh, Y. Ardeli-Tzaraf, Y. Barenholz, Y. Jawbry, S. Khazanov, E.
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems
issn	0022-2623
number of pages	9 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Cationic nonsymmetric transplatinum complexes with piperidinopiperidine ligands. Preparation, characterization, in vitro cytotoxicity, in vivo toxicity, and anticancer efficacy studies Cationic nonsymmetric transplatinum complexes with piperidinopiperidine ligands. Preparation, characterization, in vitro cytotoxicity, in vivo toxicity, and anticancer efficacy studies

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