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| Description
| - The long-term objective of this proposal is to implement fundamental research leading to broadening of the theoretical backgroung needed for the design of new antitumor transition metal-based drugs. The working hypothesis will be tested experimentally that there is a correlation between inhibition of telomerase induced by DNA adducts of platinum and ruthenium complexes and antitumor activity of these compounds. Confirmation of this hypothesis will make it possible to define a new concept of antitumor effects of platinum and ruthenium compounds. This new concept will allow designing new antitumor drugs which will have better therapeutic properties than those already used in the clinic. (en)
- Obecným cílem tohoto projektu je realizovat základní výzkum vedoucí k rozšíření teoretického zázemí pro vývoj nových cytostatik odvozených od komplexů přechodných kovů. Experimentálně bude testována pracovní hypotéza, podle které existuje korelace mezi inhibicí telomerázy vyvolané poškozením DNA po její reakcí s komplexy platiny a ruthenia a jejich protinádorovou aktivitou. Potvrzení této hypotézy umožní definovat novou koncepci cytostatických účinků komplexů platiny a ruthenia, na základě které budou navržena léčiva, jejichž protinádorové účinky budou lepší ve srovnání s účinky cytostatik již využívaných v klinické praxi.
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| Title
| - Inhibition of telomerase by transition metal complexes. A new concept of antitumor drug design (en)
- Inhibice telomerázy komplexy přechodných kovů. Nová koncepce vývoje nových cytostatik
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| skos:notation
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| http://linked.open...avai/cep/aktivita
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| http://linked.open...kovaStatniPodpora
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| http://linked.open...ep/celkoveNaklady
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| http://linked.open...datumDodatniDoRIV
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| http://linked.open...i/cep/druhSouteze
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| http://linked.open...ep/duvernostUdaju
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| http://linked.open.../cep/fazeProjektu
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| http://linked.open...ai/cep/hlavniObor
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| http://linked.open...hodnoceniProjektu
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| http://linked.open...vai/cep/kategorie
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| http://linked.open.../cep/klicovaSlova
| - cancer; DNA; platinum; antitumor; telomerase; conformation; ruthenium (en)
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| http://linked.open...ep/partnetrHlavni
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| http://linked.open...inujicichPrijemcu
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| http://linked.open...cep/pocetPrijemcu
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| http://linked.open...ocetSpoluPrijemcu
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| http://linked.open.../pocetVysledkuRIV
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| http://linked.open...enychVysledkuVRIV
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| http://linked.open...lneniVMinulemRoce
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| http://linked.open.../prideleniPodpory
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| http://linked.open...iciPoslednihoRoku
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| http://linked.open...atUdajeProjZameru
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| http://linked.open.../vavai/cep/soutez
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| http://linked.open...usZobrazovaneFaze
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| http://linked.open...ai/cep/typPojektu
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| http://linked.open...ep/ukonceniReseni
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| http://linked.open.../cep/vedlejsiObor
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| http://linked.open...ep/zahajeniReseni
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| http://linked.open...jektu+dodavatelem
| - Byly zjištěny korelace mezi modifikací DNA komplexy přechodných kovů a jejich protinádorovou aktivitou. Byl navržen mechanismus kterým tyto komplexy mohou inhibovat aktivitu telomerazy. (cs)
- Correlations between modification of DNA by transition metal compounds and their antitumor activity were found. A mechanism was proposed by which these compounds may inhibit activity of telomerase. (en)
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| http://linked.open...tniCyklusProjektu
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| http://linked.open.../cep/klicoveSlovo
| - cancer
- DNA
- antitumor
- conformation
- platinum
- telomerase
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| is http://linked.open...vavai/riv/projekt
of | - Modifications of DNA by platinum complexes. Relation to resistance of tumors to platinum antitumor drugs
- Metal compounds in cancer chemotherapy
- Synthesis, biophysical studies, and antiproliferative activity of platinum(II) complexes having 1,2-bis(aminomethyl)carbobicyclic ligands
- Amide-based prodrugs of spermidine-bridged dinuclear platinum. Synthesis, DNA binding, and biological activity
- Cytotoxicity, mutagenicity, cellular uptake, DNA and glutathione interactions of lipophilic trans-platinum complexes tethered to 1-adamantylamine
- DNA binding of dinuclear iron(II) metallosupramolecular cylinders. DNA unwinding and sequence preference
- DNA interactions of monofunctional organometallic osmium(II) antitumor complexes in cell-free media
- Interaction of dinuclear ruthenium(II) supramolecular cylinders with DNA: sequence-specific binding, unwinding, and photocleavage
- Unique properties of DNA interstrand cross-links of antitumor oxaliplatin and the effect of chirality of the carrier ligand
- DNA adducts of antitumor cisplatin preclude telomeric sequences from forming G quadruplexes
- Role of DNA repair in antitumour effects of platinum drugs
- Conformation, protein recognition and repair of DNA interstrand and intrastrand cross-links of antitumor trans-[PtCl2(NH3)(thiazole)]
- Structural characterization and DNA interactions of new cytotoxic transplatin analogues containing one planar and one nonplanar heterocyclic amine ligand.
- Biophysical Studies on the Stability of DNA Intrastrand Cross-Links of Transplatin
- Deoxyribonuclease I footprinting reveals different DNA binding modes of bifunctional platinum complexes
- Lymphoid differentiation pathways can be traced by TCRdelta rearrangements
- Cytotoxicity, cellular uptake, and DNA interactions of new monodentate ruthenium(II) complexes containing terphenyl arenes
- The contrasting chemistry and cancer cell cytotoxicity of bipyridine and bipyridinediol ruthenium(II) arene complexes
- DNA and glutathione interactions in cell-free media of asymmetric platinum(II) complexes cis- and trans-[PtCl2(isopropylamine)(1-methylimidazole)]: relations to their different antitumor effects
- Cationic nonsymmetric transplatinum complexes with piperidinopiperidine ligands. Preparation, characterization, in vitro cytotoxicity, in vivo toxicity, and anticancer efficacy studies
- Thermodynamic properties of damaged DNA and its recognition by xeroderma pigmentosum group A protein and replication protein A
- Molecular aspects of antitumor effects of a new platinum(IV) drug
- Recogntiton of DNA modified by trans-[PtCl2NHš(4-hydroxymethylpyridine)] by tumor suppressor protein p53 and character of DNA adducts of this cytotoxic complex
- Transplatin is cytotoxic when photoactivated: Enhanced formation of DNA cross-links
- High-throughput screening identifies novel agents eliciting hypersensitivity in Fanconi pathway-deficient cancer cells
- 1,2-GG intrastrand cross-link of antitumor dinuclear bifunctional platinum compound with spermidine linker inhibits DNA polymerization more effectively than the cross-link of conventional cisplatin
- Mechanism of the formation of DNA-protein cross-links by antitumor cisplatin
- DNA interactions of new cytotoxic tetrafunctional dinuclear platinum complex trans,trans-[{PtCl2(NH3)}2(piperazine)]
- Biochemical studies of the thermal effects on DNA modifications by the antitumor cisplatin and their repair
- A potent cytotoxic photoactivated platinum complex
- Interactions of platinum complexes containing cationic, bicyclic, nonplanar piperidinopiperidine ligands with biological nucleophiles
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| is http://linked.open...vavai/cep/projekt
of | |
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