About: Biophysical Studies on the Stability of DNA Intrastrand Cross-Links of Transplatin

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Clinically ineffective transplatin [trans-diamminedichloridoplatinum(II)] is used in the studies of the structure-pharmacological activity relationship of platinum compounds. In addition, a number of transplatin analogs exhibit promising toxic effects in several tumor cell lines including those resistant to conventional antitumor cisplatin. Moreover, transplatin-modified oligonucleotides have been shown to be effective modulators of gene expression. Owing to these facts and because DNA is also considered the major pharmacological target of platinum complexes, interactions between transplatin and DNA are of great interest. We examined, using biophysical and biochemical methods, the stability of 1,3-GNG intrastrand cross-links (CLs) formed by transplatin in short synthetic oligodeoxyribonucleotide duplexes and natural double-helical DNA. We have found that transplatin forms in double-helical DNA 1,3-GNG intrastrand CLs, but their stability depends on the sequence context. Clinically ineffective transplatin [trans-diamminedichloridoplatinum(II)] is used in the studies of the structure-pharmacological activity relationship of platinum compounds. In addition, a number of transplatin analogs exhibit promising toxic effects in several tumor cell lines including those resistant to conventional antitumor cisplatin. Moreover, transplatin-modified oligonucleotides have been shown to be effective modulators of gene expression. Owing to these facts and because DNA is also considered the major pharmacological target of platinum complexes, interactions between transplatin and DNA are of great interest. We examined, using biophysical and biochemical methods, the stability of 1,3-GNG intrastrand cross-links (CLs) formed by transplatin in short synthetic oligodeoxyribonucleotide duplexes and natural double-helical DNA. We have found that transplatin forms in double-helical DNA 1,3-GNG intrastrand CLs, but their stability depends on the sequence context. (en)
Title	Biophysical Studies on the Stability of DNA Intrastrand Cross-Links of Transplatin Biophysical Studies on the Stability of DNA Intrastrand Cross-Links of Transplatin (en)
skos:prefLabel	Biophysical Studies on the Stability of DNA Intrastrand Cross-Links of Transplatin Biophysical Studies on the Stability of DNA Intrastrand Cross-Links of Transplatin (en)
skos:notation	RIV/00216224:14310/08:00035832!RIV11-MSM-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1QS500040581), P(IAA400040803), P(KAN200200651), P(LC06030), P(ME08017), P(NR8562), P(OC08003), Z(AV0Z50040507), Z(AV0Z50040702), Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika	9
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Brabec, Viktor Kašpárková, Jana Marini Palomeque, María Victoria Bursová, Vendula
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	358168
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/08:00035832
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	transplatin; DNA; antitumor (en)
http://linked.open.../riv/klicoveSlovo	DNA antitumor transplatin
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[10C686FD3C9F]
http://linked.open...i/riv/nazevZdroje	Biophysical Journal
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Metallodrugs, design and mechansim of action Platinum Metal Complexes as DNA-Protein Cross-Linking Agents Structure, recognition, and processing of DNA damage by metal-based compounds of biological significance Nanoparticulate and supramolecular systems for targeted drug delivery Biomolecular centre Inhibition of telomerase by transition metal complexes. A new concept of antitumor drug design Mechanistic studies related to targeted cancer chemotherapy with light-activated platinum and ruthenium antitumor agents
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	95
http://linked.open...iv/tvurceVysledku	Brabec, Viktor Kašpárková, Jana Marini Palomeque, María Victoria Bursová, Vendula
http://linked.open...ain/vavai/riv/wos	000260072600028
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions Modulation of signalling and regulatory pathways in normal and cancer cells
issn	0006-3495
number of pages	11 (xsd:int)
http://localhost/t...ganizacniJednotka	14310
is http://linked.open...avai/riv/vysledek of	Biophysical Studies on the Stability of DNA Intrastrand Cross-Links of Transplatin Biophysical Studies on the Stability of DNA Intrastrand Cross-Links of Transplatin Biophysical Studies on the Stability of DNA Intrastrand Cross-Links of Transplatin

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