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| rdf:type
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| rdfs:seeAlso
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| Description
| - This project is aimed to find out data on covalent interactions of DNA modified by platinum complexes with proteins. (en)
- Cílem tohoto výzkumu je zjistit údaje o kovalentních interakcích DNA modifikované komplexy platiny s proteiny.
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| Title
| - Platinum Metal Complexes as DNA-Protein Cross-Linking Agents (en)
- Komplexy platiny jako agens vhodná pro vytváření můstků mezi DNA a bílkovinami
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| skos:notation
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| http://linked.open...avai/cep/aktivita
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| http://linked.open...kovaStatniPodpora
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| http://linked.open...ep/celkoveNaklady
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| http://linked.open...datumDodatniDoRIV
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| http://linked.open...i/cep/druhSouteze
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| http://linked.open...ep/duvernostUdaju
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| http://linked.open.../cep/fazeProjektu
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| http://linked.open...ai/cep/hlavniObor
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| http://linked.open...hodnoceniProjektu
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| http://linked.open...vai/cep/kategorie
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| http://linked.open.../cep/klicovaSlova
| - DNA; protein; cross-links; platinum; antitumor activity (en)
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| http://linked.open...ep/partnetrHlavni
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| http://linked.open...inujicichPrijemcu
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| http://linked.open...cep/pocetPrijemcu
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| http://linked.open...ocetSpoluPrijemcu
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| http://linked.open.../pocetVysledkuRIV
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| http://linked.open...enychVysledkuVRIV
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| http://linked.open...lneniVMinulemRoce
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| http://linked.open.../prideleniPodpory
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| http://linked.open...iciPoslednihoRoku
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| http://linked.open...atUdajeProjZameru
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| http://linked.open.../vavai/cep/soutez
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| http://linked.open...usZobrazovaneFaze
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| http://linked.open...ai/cep/typPojektu
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| http://linked.open...ep/ukonceniReseni
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| http://linked.open.../cep/vedlejsiObor
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| http://linked.open...ep/zahajeniReseni
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| http://linked.open...jektu+dodavatelem
| - Společné a komplementární studie s partnerským pracovištěm v USA poskytly výsledky, které ukazují na možnosti využití komplexů přechodných kovů jako agens vhodných pro vytváření můstků mezi DNA a proteiny. Řešení projektu umožnilo podílet se na aktivitách mezinárodní spolupráce ve výzkumu a vývoji, založených na mezinárodní smlouvě o vědeckotechnické spolupráci s National Science Foundation v USA. (cs)
- Joint and complementary studies with a US laboratory provided results demonstrating that transition-metal based complexes can be used as agents capable of forming cross-links between DNA and proteins. The implementation of this project made it posible to participate in the international cooperation in R&D based on the agreement on the scientific and technical cooperation with the NSF (USA). (en)
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| http://linked.open...tniCyklusProjektu
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| http://linked.open.../cep/klicoveSlovo
| - DNA
- platinum
- protein
- cross-links
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| is http://linked.open...vavai/riv/projekt
of | - Interaction of dinuclear ruthenium(II) supramolecular cylinders with DNA: sequence-specific binding, unwinding, and photocleavage
- DNA interactions of dinuclear RuII arene antitumor complexes in cell-free media
- Energetics, conformation, and recognition of DNA duplexes modified by methylated analogues of [PtCl(dien)]+
- DNA adducts of antitumor cisplatin preclude telomeric sequences from forming G quadruplexes
- Studies of the mechanism of action of platinum(II) complexes with potent cytotoxicity in human cancer cells
- Factors affecting DNA-DNA interstrand cross-links in the antiparallel 3'-3' sense: A comparison with the 5'-5' directional isomer
- Mechanistic studies of the modulation of cleavage activity of topoisomerase I by DNA adducts of mono- and bi-functional Pt-II complexes
- Role of DNA repair in antitumour effects of platinum drugs
- Studies on cellular accumulation of satraplatin and its major metabolite JM118 and their interactions with glutathione
- Mechanistic insights into antitumor effects of new dinuclear cis PtII complexes containing aromatic linkers
- Walking of antitumor bifunctional trinuclear Pt II complex on double-helical DNA
- Biophysical Studies on the Stability of DNA Intrastrand Cross-Links of Transplatin
- Different features of the DNA binding mode of antitumor cis-amminedichlorido(cyclohexylamine)platinum(II) (JM118) and cisplatin in vitro
- Conformation and recognition of DNA modified by a new antitumor dinuclear PtII complex resistant to decomposition by sulfur nucleophiles
- Energetics, conformation, and recognition of DNA duplexes modified by monodentate Ru(II) complexes containing terphenyl arenes
- Cytotoxicity, cellular uptake, glutathione and DNA interactions of an antitumor large-ring PtII chelate complex incorporating the cis-1,4-diaminocyclohexane carrier ligand
- A metal-free DNA nuclease based on a cyclic peptide scaffold
- Cytotoxicity, cellular uptake, and DNA interactions of new monodentate ruthenium(II) complexes containing terphenyl arenes
- The contrasting chemistry and cancer cell cytotoxicity of bipyridine and bipyridinediol ruthenium(II) arene complexes
- DNA and glutathione interactions in cell-free media of asymmetric platinum(II) complexes cis- and trans-[PtCl2(isopropylamine)(1-methylimidazole)]: relations to their different antitumor effects
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| is http://linked.open...vavai/cep/projekt
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