About: DNA and glutathione interactions in cell-free media of asymmetric platinum(II) complexes cis- and trans-[PtCl2(isopropylamine)(1-methylimidazole)]: relations to their different antitumor effects

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About: DNA and glutathione interactions in cell-free media of asymmetric platinum(II) complexes cis- and trans-[PtCl2(isopropylamine)(1-methylimidazole)]: relations to their different antitumor effects Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The global modification of mammalian and plasmid DNAs by the novel platinum compounds cis-[PtCl2(isopropylamine)(1-methylimidazole)] and trans-[PtCl2(isopropylamine)(1-methylimidazole)] and the reactivity of these compounds with reduced glutathione (GSH) were investigated. The results of this work support the hypothesis that platinum drugs that bind to DNA in a fundamentally different manner from that of conventional cisplatin may have altered pharmacological properties. The global modification of mammalian and plasmid DNAs by the novel platinum compounds cis-[PtCl2(isopropylamine)(1-methylimidazole)] and trans-[PtCl2(isopropylamine)(1-methylimidazole)] and the reactivity of these compounds with reduced glutathione (GSH) were investigated. The results of this work support the hypothesis that platinum drugs that bind to DNA in a fundamentally different manner from that of conventional cisplatin may have altered pharmacological properties. (en)
Title	DNA and glutathione interactions in cell-free media of asymmetric platinum(II) complexes cis- and trans-[PtCl2(isopropylamine)(1-methylimidazole)]: relations to their different antitumor effects DNA and glutathione interactions in cell-free media of asymmetric platinum(II) complexes cis- and trans-[PtCl2(isopropylamine)(1-methylimidazole)]: relations to their different antitumor effects (en)
skos:prefLabel	DNA and glutathione interactions in cell-free media of asymmetric platinum(II) complexes cis- and trans-[PtCl2(isopropylamine)(1-methylimidazole)]: relations to their different antitumor effects DNA and glutathione interactions in cell-free media of asymmetric platinum(II) complexes cis- and trans-[PtCl2(isopropylamine)(1-methylimidazole)]: relations to their different antitumor effects (en)
skos:notation	RIV/61989592:15310/09:10218828!RIV11-MSM-15310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1QS500040581), P(IAA400040803), P(KAN200200651), P(LC06030), P(ME08017), P(NR8562), P(OC08003), Z(AV0Z50040507), Z(AV0Z50040702), Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Brabec, Viktor
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	310996
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/09:10218828
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	effects; antitumor; different; relations; trans-[PtCl2(isopropylamine)(1-methylimidazole)]:; cis-; complexes; platinum(II); asymmetric; media; cell-free; interactions; glutathione; DNA (en)
http://linked.open.../riv/klicoveSlovo	DNA complexes different effects interactions media antitumor relations asymmetric glutathione cell-free cis- platinum(II) trans-[PtCl2(isopropylamine)(1-methylimidazole)]:
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[19C240DECEDE]
http://linked.open...i/riv/nazevZdroje	Journal of Biological Inorganic Chemistry
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Metallodrugs, design and mechansim of action Platinum Metal Complexes as DNA-Protein Cross-Linking Agents Structure, recognition, and processing of DNA damage by metal-based compounds of biological significance Nanoparticulate and supramolecular systems for targeted drug delivery Biomolecular centre Inhibition of telomerase by transition metal complexes. A new concept of antitumor drug design Mechanistic studies related to targeted cancer chemotherapy with light-activated platinum and ruthenium antitumor agents
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	14
http://linked.open...iv/tvurceVysledku	Brabec, Viktor Kašpárková, Jana Suchánková, Tereza Vojtíšková, Marie Reedijk, Jan
http://linked.open...ain/vavai/riv/wos	000261342300007
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions Modulation of signalling and regulatory pathways in normal and cancer cells
issn	0949-8257
number of pages	13 (xsd:int)
http://localhost/t...ganizacniJednotka	15310
is http://linked.open...avai/riv/vysledek of	DNA and glutathione interactions in cell-free media of asymmetric platinum(II) complexes cis- and trans-[PtCl2(isopropylamine)(1-methylimidazole)]: relations to their different antitumor effects DNA and glutathione interactions in cell-free media of asymmetric platinum(II) complexes cis- and trans-[PtCl2(isopropylamine)(1-methylimidazole)]: relations to their different antitumor effects DNA and glutathione interactions in cell-free media of asymmetric platinum(II) complexes cis- and trans-[PtCl2(isopropylamine)(1-methylimidazole)]: relations to their different antitumor effects

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