About: Conformation of DNA GG intrastrand cross-link of antitumor oxaliplatin and its enantiomeric analog

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About: Conformation of DNA GG intrastrand cross-link of antitumor oxaliplatin and its enantiomeric analog Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Differences in conformation, recognition by HMG domain protein and DNA polymerization across the major 1,2-GG intrastrand cross-link formed by cisplatin and oxaliplatin in three sequence contexts were described with the aid of biophysical and biochemical methods. It has been also demonstrated that the chirality at the carrier ligand of oxaliplatin can affect its biological effects. Differences in conformation, recognition by HMG domain protein and DNA polymerization across the major 1,2-GG intrastrand cross-link formed by cisplatin and oxaliplatin in three sequence contexts were described with the aid of biophysical and biochemical methods. It has been also demonstrated that the chirality at the carrier ligand of oxaliplatin can affect its biological effects. (en) Byly popsány rozdíly v konformaci, rozlišení proteiny HMG a DNA syntéze přes hlavní vnitrořetězcový můstek vytvořený v sekvenci GG cisplatinou a oxaliplatinou pomocí biofyzikálních a biochemických metod. Bylo také ukázáno, že chiralita v neodstupujícím ligandu oxaliplatiny může ovlivnit její biologické efekty. (cs)
Title	Conformation of DNA GG intrastrand cross-link of antitumor oxaliplatin and its enantiomeric analog Konformace vnitrořetězcového můstku GG v DNA protinádorově účinné oxaliplatiny a jejího enanciomerního analogu (cs) Conformation of DNA GG intrastrand cross-link of antitumor oxaliplatin and its enantiomeric analog (en)
skos:prefLabel	Conformation of DNA GG intrastrand cross-link of antitumor oxaliplatin and its enantiomeric analog Konformace vnitrořetězcového můstku GG v DNA protinádorově účinné oxaliplatiny a jejího enanciomerního analogu (cs) Conformation of DNA GG intrastrand cross-link of antitumor oxaliplatin and its enantiomeric analog (en)
skos:notation	RIV/68081707:_____/07:00092222!RIV08-AV0-68081707
http://linked.open.../vavai/riv/strany	3950;3962
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1QS500040581), P(GA203/06/1239), P(GA305/05/2030), P(KAN200200651), P(KJB400040601), P(LC06030), Z(AV0Z50040507), Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika	11
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Brabec, Viktor Nováková, Olga Malina, Jaroslav Vojtíšková, Marie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	414789
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/07:00092222
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	DNA; oxaliplatina; cancer (en)
http://linked.open.../riv/klicoveSlovo	oxaliplatina DNA cancer
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[09F3B88C9B3B]
http://linked.open...i/riv/nazevZdroje	Biophysical Journal
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Metallodrugs, design and mechansim of action Recognition of DNA modified by antitumor platinum and ruthenium complexes by zinc-finger proteins and topoisomerases New approaches to cancer chemotherapy by metal-based drugs Nanoparticulate and supramolecular systems for targeted drug delivery Biomolecular centre Tolerance and bypass of DNA damage by metal-based anticancer drugs
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	93
http://linked.open...iv/tvurceVysledku	Brabec, Viktor Malina, Jaroslav Nováková, Olga Vojtíšková, Marie Natile, G.
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions
issn	0006-3495
number of pages	13 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Conformation of DNA GG intrastrand cross-link of antitumor oxaliplatin and its enantiomeric analog Conformation of DNA GG intrastrand cross-link of antitumor oxaliplatin and its enantiomeric analog Conformation of DNA GG intrastrand cross-link of antitumor oxaliplatin and its enantiomeric analog

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