About: Raman spectroscopy of DNA modified by intrastrand cross-links of antitumor cisplatin

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Raman spectroscopy of DNA modified by intrastrand cross-links of antitumor cisplatin Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Ramanova spektroskopie byla využita pro charakterizace narušení konformace DNA vyvolaného v DNA vnitrořetězcovými můstky cis-diammindichloroplatnatým komplexu (cisplatiny), jmenovitě vnitrořetězcovými můstky 1,2-GG nebo 1,3-GTG. Výsledky ukazují, že Ramanova spektroskopie představuje vhodný nástroj ke studiu strukturních faktorů hrajících roli v protinádorových účincích platinových cytostatik. (cs) Raman spectroscopy was employed to characterize the perturbations to DNA conformation induced in DNA by two different intrastrand adducts of antitumor cis-diamminedichloroplatinum(II) (cisplatin), namely by its 1,2-GG or 1,3-GTG intrastrand cross-links. The results demonstrate that Raman spectroscopy represents a suitable tool to provide insights into structural factors involved in the mechanisms underlying antitumor effects of platinum drugs. Raman spectroscopy was employed to characterize the perturbations to DNA conformation induced in DNA by two different intrastrand adducts of antitumor cis-diamminedichloroplatinum(II) (cisplatin), namely by its 1,2-GG or 1,3-GTG intrastrand cross-links. The results demonstrate that Raman spectroscopy represents a suitable tool to provide insights into structural factors involved in the mechanisms underlying antitumor effects of platinum drugs. (en)
Title	Raman spectroscopy of DNA modified by intrastrand cross-links of antitumor cisplatin Ramanova spektroskopie DNA modifikované vnitrořetězcovými můstky protinádorově účinné cisplatiny (cs) Raman spectroscopy of DNA modified by intrastrand cross-links of antitumor cisplatin (en)
skos:prefLabel	Raman spectroscopy of DNA modified by intrastrand cross-links of antitumor cisplatin Ramanova spektroskopie DNA modifikované vnitrořetězcovými můstky protinádorově účinné cisplatiny (cs) Raman spectroscopy of DNA modified by intrastrand cross-links of antitumor cisplatin (en)
skos:notation	RIV/68081707:_____/07:00083878!RIV08-AV0-68081707
http://linked.open.../vavai/riv/strany	1;8
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1P05OC070), P(1P05OC072), P(1QS500040581), P(GA203/05/2032), P(GA305/05/2030), P(GD204/03/H016), P(KAN200200651), P(LC06030), Z(AV0Z50040507), Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Mašek, Vlastimil Brabec, Viktor Dražan, Viktor Vrána, Oldřich
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	446372
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/07:00083878
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	DNA; platinum; cancer (en)
http://linked.open.../riv/klicoveSlovo	DNA cancer platinum
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[7BAFD29B049A]
http://linked.open...i/riv/nazevZdroje	Journal of Structural Biology
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Intracellular and extracellular targets for antitumor activity and toxicity of ruthenium complexex Non-covalent DNA recognition strategies for design and synthesis of new metallo-drugs Metallodrugs, design and mechansim of action New approaches to cancer chemotherapy by metal-based drugs Nanoparticulate and supramolecular systems for targeted drug delivery Biomolecular centre Structural biophysics of macromolecules Raman spectroscopy of DNA modified by antitumor metal-based compounds
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	159
http://linked.open...iv/tvurceVysledku	Brabec, Viktor Mašek, Vlastimil Vrána, Oldřich Dražan, Viktor
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions
issn	1047-8477
number of pages	8 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Raman spectroscopy of DNA modified by intrastrand cross-links of antitumor cisplatin Raman spectroscopy of DNA modified by intrastrand cross-links of antitumor cisplatin Raman spectroscopy of DNA modified by intrastrand cross-links of antitumor cisplatin

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 58 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software