About: Structure, recognition and biochemistry of DNA modified by antitumor platinum drugs

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/domain/vavai/Projekt
rdfs:seeAlso	http://www.isvav.cz/projectDetail.do?rowId=IAA5004101
Description	This project is aimed at complex studies of the mechanism of anticancer activity of platinum-based compounds. The goal of these studies is to develop a systematic and complex theoretical background to the synthesis of novel platinum complexes with unique DNA binding activities capable of overcoming the problem of cellular resistance to platinum drugs already used in the clinic and of their limited activity against the most common tumors. An important aspect is to examine and compare the mechanism of action of platinum complexes structurally distinct from those used in the clinic. The anticancer activity of platinum complexes arises from their ability do damage DNA. Therefore, the systematic studies will be performed aimed at analysis of DNA binding modes of a series of novel platinum complexes by biophysical and biochemical methods. A particular attention will be paid to local conformational alterations, their recognition by specific proteins and repair. (en) Projekt je zaměřen na komplexní studii mechanismu protinádorové účinnosti sloučenin odvozených od koordinačních komplexů platiny. Cílem je vyvinout komplexní teor. základnu pro syntézu nových komplexů platiny vyznačujících se jednak schopností unikátná vazby k DNA, jednak schopností překonat problémy i) buněčné rezistence vůči platinovým cytostatikům již využívaným v klinické praxi, ii) jejich omezené aktivity v nejběžnějších nádorech. Důležitým aspektem projektu je zkoumání a srovnání mechanismů biologického působení platinových komplexů strukturně odlišných zkoumání a srovnání mechanismů biol. působení platinových komplexů strukturně odlišných od komplexů již využívaných v klin. praxi. Protinádorová účinnost sloučenin platiny souvisí s jejich schopností poškodit DNA. Bude proto provedena systematická studie zaměřená na analýzu modifikace DNA serií nových komplexů platiny, které se liší biologickou účinností, biofyzikálními a biochem. metodami.
Title	Structure, recognition and biochemistry of DNA modified by antitumor platinum drugs (en) Struktura, rozlišení a biochemie DNA modifikované platinovými cytostatiky
skos:notation	IAA5004101
http://linked.open...avai/cep/aktivita	Grants of distinctly investigative character focused on the sphere of research pursued at present particularly in the Academy of Sciences of the Czech Republic
http://linked.open...kovaStatniPodpora	http://linked.opendata.cz/resource/domain/vavai/projekt/IAA5004101/celkovaStatniPodpora
http://linked.open...ep/celkoveNaklady	http://linked.opendata.cz/resource/domain/vavai/projekt/IAA5004101/celkoveNaklady
http://linked.open...datumDodatniDoRIV	2007-09-26 (xsd:date)
http://linked.open...i/cep/druhSouteze	VS - Veřejná soutěž ve výzkumu a vývoji
http://linked.open...ep/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open.../cep/fazeProjektu	33613950
http://linked.open...ai/cep/hlavniObor	EB - Genetika a molekulární biologie
http://linked.open...hodnoceniProjektu	V - Vynikající výsledky (s mezinárodním významem apod.). Zároveň byly splněny cíle a předpokládané výsledky uvedené ve smlouvě / rozhodnutí o poskytnutí podpory.
http://linked.open...vai/cep/kategorie	ZV - Základní výzkum
http://linked.open.../cep/klicovaSlova	anticancer drugs; DNA; cross-links; conformation; DNA-binding proteins; DNA repair (en)
http://linked.open...ep/partnetrHlavni	Biofyzikální ústav AV ČR, v.v.i.
http://linked.open...inujicichPrijemcu	0 (xsd:int)
http://linked.open...cep/pocetPrijemcu	1 (xsd:int)
http://linked.open...ocetSpoluPrijemcu	0 (xsd:int)
http://linked.open.../pocetVysledkuRIV	26 (xsd:int)
http://linked.open...enychVysledkuVRIV	26 (xsd:int)
http://linked.open...okUkonceniPodpory	2005
http://linked.open...okZahajeniPodpory	2001
http://linked.open...iciPoslednihoRoku	2006
http://linked.open...atUdajeProjZameru	2006
http://linked.open.../vavai/cep/soutez	SAV0-AB2001
http://linked.open...usZobrazovaneFaze	DUU
http://linked.open...ai/cep/typPojektu	P - Projekt výzkumu a vývoje financovaný ze státního rozpočtu
http://linked.open.../cep/vedlejsiObor	FR - Farmakologie a lékárnická chemie FD - Onkologie a hematologie
http://linked.open...jektu+dodavatelem	Details of DNA binding mode of novel antitumor platinum compounds were determined. These data make it possible to reevaluate the structure-pharmacological relationships of platinum complexes required when new anticancer drugs are designed.????? (en) Byly zjištěny podrobnosti vazby nových protinádorově účinných komplexů platiny k DNA. Tyto údaje umožňují přehodnotit vztahy mezi strukturou a farmakologickou aktivitou komplexů platiny využívané při návrzích nových léčiv proti rakovině. (cs)
http://linked.open...tniCyklusProjektu	ZBBBKU
http://linked.open.../cep/klicoveSlovo	anticancer drugs DNA conformation DNA-binding proteins cross-links
is http://linked.open...vavai/riv/projekt of	DNA adducts of the enantiomers of the Pt(II) complexes of the ahaz ligand (ahaz=3-aminohexahydroazepine) and recognition of these adducts by HMG domain proteins Chiral differentiation of DNA adducts formed by enantiomeric analogues of antitumor cisplatin is sequence-dependent Effects of monofunctional adducts of Platinum(II) complexes on thermodynamic stability and energetics of DNA duplexes Platinum-based drugs Differential recognition by the tumor suppressor protein p53 of DNA modified by the novel antitumor trinuclear platinum drug BBR3464 and cisplatin Conformation, protein recognition and repair of DNA interstrand and intrastrand cross-links of antitumor trans-[PtCl2(NH3)(thiazole)] Formation of platinated GG cross-links on DNA by photoactivation of a Pt(IV) azide complex. Thermodynamic properties of duplex DNA containing a site-specific d(GpG) intrastrand crosslink formed by an antitumor dinuclear platinum complex. A comparison of DNA binding profiles of dinuclear platinum compounds with polyamine linkers and the trinuclear platinum phase II clinical agent BBR3464 DNA modifications by antitumor platinum and ruthenium compounds: Their recognition and repair. Differential genotoxic effects of antitumor trans-[PtCl2(E-iminoether)2] and cisplatin in Escherichia coli. DNA modifications by novel antitumor platinum drugs. DNA bending and unwinding due to the major 1,2-GG intrastrand cross-link formed by antitumor cis-diamminedichloroplatinum(II) are flanking-base independent. DNA interstrand cross-links of the novel antitumor trinuclear platinum complex BBR3464: Conformation, recognition by high mobility group domain proteins, and nucleotide excision repair. L-Methionine inhibits reaction of DNA with anticancer cis-diamminedichloroplatinum(II). Recognition of major DNA adducts of enantiomeric cisplatin analogs by HMG box proteins and nucleotide excision repair of these adducts. DNA Binding Mode of the Cis and Trans Geometries of New Antitumor Nonclassical Platinum Complexes Containing Piperidine, Piperazine, or 4-Picoline Ligand in Cell-Free Media. Relations to Their Activity in Cancer Cell Lines DNA interactions of monofuntional organometallic ruthenium(II) antitumor complexes in cell-free media. DNA binding by antitumor trans-[PtCl2(NH3)(thiazole)]. Protein recognition and nucleotide excision repair of monofunctional adducts. Biophysical analysis of natural, double-helical DNA modified by a dinuclear platinum(II) organometallic compound in a cell-free medium Molecular aspects of resistance to antitumor platinum drugs. Conformation, Recognition by High Mobility Group Domain Proteins, and Nucleotide Excision Repair of DNA Intrastrand Cross-links of Novel Antitumor Trinuclear Platinum Complex BBR3464. Melting of cross-linked DNA V. Cross-linking effect caused by local stabilization of the double helix. Different Recognition of DNA Modified by Antitumor Cisplatin and Its Clinically Ineffective trans Isomer by Tumor Suppressor Protein p53. Induced-fit recognition of DNA by organometallic complexes with dynamic stereogenic centers. Trifunctional dinuclear platinum complexes as DNA-protein cross-linking agents
is http://linked.open...vavai/cep/projekt of	http://linked.opendata.cz/resource/domain/vavai/cep/ucast/IAA5004101/2001/ico%3A68081707 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/IAA5004101/2002/ico%3A68081707 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/IAA5004101/2003/ico%3A68081707 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/IAA5004101/2004/ico%3A68081707 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/IAA5004101/2005/ico%3A68081707 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/IAA5004101/2006/ico%3A68081707

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