About: Thermodynamic properties of duplex DNA containing a site-specific d(GpG) intrastrand crosslink formed by an antitumor dinuclear platinum complex.

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About: Thermodynamic properties of duplex DNA containing a site-specific d(GpG) intrastrand crosslink formed by an antitumor dinuclear platinum complex. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Differential scannning calorimetry and spectroscopic techniques were employed to characterize the influence of this cross-link on the thermal stability and energetics of 20 base pairs DNA duplexes site-specifically modified by [{trans/PtCl(NH3)2}2H2N(CH2)4NH2]CL2. The results are consistent with different DNA binding modes of cisplatin and polynuclear bifunctional DNA/binding drugs, which might be relevant to their distinct biological effectiveness. Differential scannning calorimetry and spectroscopic techniques were employed to characterize the influence of this cross-link on the thermal stability and energetics of 20 base pairs DNA duplexes site-specifically modified by [{trans/PtCl(NH3)2}2H2N(CH2)4NH2]CL2. The results are consistent with different DNA binding modes of cisplatin and polynuclear bifunctional DNA/binding drugs, which might be relevant to their distinct biological effectiveness. (en)
Title	Thermodynamic properties of duplex DNA containing a site-specific d(GpG) intrastrand crosslink formed by an antitumor dinuclear platinum complex. Thermodynamic properties of duplex DNA containing a site-specific d(GpG) intrastrand crosslink formed by an antitumor dinuclear platinum complex. (en)
skos:prefLabel	Thermodynamic properties of duplex DNA containing a site-specific d(GpG) intrastrand crosslink formed by an antitumor dinuclear platinum complex. Thermodynamic properties of duplex DNA containing a site-specific d(GpG) intrastrand crosslink formed by an antitumor dinuclear platinum complex. (en)
skos:notation	RIV/68081707:_____/01:17013005!RIV/2003/AV0/A17003/N
http://linked.open.../vavai/riv/strany	2034;2040
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA305/99/0695), P(IAA5004101), P(IBS5004009), Z(AV0Z5004920)
http://linked.open...iv/cisloPeriodika	10
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Brabec, Viktor Hofr, Ctirad
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	698752
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/01:17013005
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	N/A (en)
http://linked.open.../riv/klicoveSlovo	N/A
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[CF04AFA2D9C8]
http://linked.open...i/riv/nazevZdroje	Nucleic Acids Research
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Affection of DNA conformation by metal-based anticancer drugs. Relations to the development of new cytostatics Structure, recognition and biochemistry of DNA modified by antitumor platinum drugs Untraditional therapeutic approaches in oncology
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	29
http://linked.open...iv/tvurceVysledku	Brabec, Viktor Hofr, Ctirad Farrell, N.
http://linked.open...n/vavai/riv/zamer	Biophysical properties of living systems and their changes under the influence of environmental factors
issn	0305-1048
number of pages	7 (xsd:int)

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