About: Induced-fit recognition of DNA by organometallic complexes with dynamic stereogenic centers.

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About: Induced-fit recognition of DNA by organometallic complexes with dynamic stereogenic centers. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The stereochemistry of the dinuclear complex [((eta(6)-biphenyl)RuCl(en))(2)-(CH2)(6)](2+) (3, en = ethylenediamine) was elucidated by studies of the half unit [(eta(6)-biphenyl)RuCl(Et-en)](+) (2, where Et-en is Et(H)NCH2CH2NH2). The structures of the separated RR-Ru(N) and SR-Ru(N) diastereomers of 2 were determined by x-ray crystallography. X-ray and NMR studies showed that dynamic chiral recognition of quanine can lead to high diastereoselectivity of DNA binding. The dinuclear complex induced a large unwinding of plasmid DNA and effectively inhibited DNA-directed RNA synthesis in vitro. It gave rise to interstrand cross-links on plasmid DNA, and to 1,3-GG interstrand and 1,2-GG and 1,3-GTG intrastrand cross-links on site specifically ruthenated 20-mers. The concept of induced-fit recognition of DNA by organometallic complexes containing dynamic stereogenic centers via epimerization, intercalation, and cross-linking may be useful in the design of anticancer drugs. The stereochemistry of the dinuclear complex [((eta(6)-biphenyl)RuCl(en))(2)-(CH2)(6)](2+) (3, en = ethylenediamine) was elucidated by studies of the half unit [(eta(6)-biphenyl)RuCl(Et-en)](+) (2, where Et-en is Et(H)NCH2CH2NH2). The structures of the separated RR-Ru(N) and SR-Ru(N) diastereomers of 2 were determined by x-ray crystallography. X-ray and NMR studies showed that dynamic chiral recognition of quanine can lead to high diastereoselectivity of DNA binding. The dinuclear complex induced a large unwinding of plasmid DNA and effectively inhibited DNA-directed RNA synthesis in vitro. It gave rise to interstrand cross-links on plasmid DNA, and to 1,3-GG interstrand and 1,2-GG and 1,3-GTG intrastrand cross-links on site specifically ruthenated 20-mers. The concept of induced-fit recognition of DNA by organometallic complexes containing dynamic stereogenic centers via epimerization, intercalation, and cross-linking may be useful in the design of anticancer drugs. (en)
Title	Induced-fit recognition of DNA by organometallic complexes with dynamic stereogenic centers. Induced-fit recognition of DNA by organometallic complexes with dynamic stereogenic centers. (en)
skos:prefLabel	Induced-fit recognition of DNA by organometallic complexes with dynamic stereogenic centers. Induced-fit recognition of DNA by organometallic complexes with dynamic stereogenic centers. (en)
skos:notation	RIV/68081707:_____/03:17033132!RIV/2004/AV0/A17004/N
http://linked.open.../vavai/riv/strany	14623;14628
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA305/01/0418), P(GA305/02/1552), P(IAA5004101), Z(AV0Z5004920)
http://linked.open...iv/cisloPeriodika	25
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Brabec, Viktor Nováková, Olga
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	610152
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/03:17033132
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	organometallic complexes; platinum; DNA (en)
http://linked.open.../riv/klicoveSlovo	DNA platinum organometallic complexes
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[8A7F9C0E4844]
http://linked.open...i/riv/nazevZdroje	Proceedings of the National Academy of Sciences of the United States of America
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Cellular and molecular pharmakology of platinum and ruthenium anticancer drugs Platinated oligonucleotides for selective modulation of gene expression; relations to antisense strategy and development of new drugs. Structure, recognition and biochemistry of DNA modified by antitumor platinum drugs
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	100
http://linked.open...iv/tvurceVysledku	Brabec, Viktor Chen, H. Sadler, P. J. Nováková, Olga Wang, F. Dawson, A. Parsons, S. Bella, J. Gould, R. Parkinson, J. A.
http://linked.open...n/vavai/riv/zamer	Biophysical properties of living systems and their changes under the influence of environmental factors
issn	0027-8424
number of pages	6 (xsd:int)

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