About: L-Methionine inhibits reaction of DNA with anticancer cis-diamminedichloroplatinum(II).

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About: L-Methionine inhibits reaction of DNA with anticancer cis-diamminedichloroplatinum(II). Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We studied in the present work the reactions of the 1:1 complex formed between cisplatin and L-methionine or N-acetyl-L-methionine with synthetic, single- and double-stranded oligodeoxyribonucleotides and natural, high molecular mass DNA by using high-pressure liquid chromatography and flameless atomic absorption spectrophotometry. The results demonstrate that both L-methionine and N-acetyl-L-methionine decrease the rate of reaction of cisplatin with base residues in natural, high molecular mass DNA. Thus, the possibility that cisplatin bound to methionine residues serves as a drug reservoir available for platination of DNA in the nucleus of tumor cells appears unlikely. We studied in the present work the reactions of the 1:1 complex formed between cisplatin and L-methionine or N-acetyl-L-methionine with synthetic, single- and double-stranded oligodeoxyribonucleotides and natural, high molecular mass DNA by using high-pressure liquid chromatography and flameless atomic absorption spectrophotometry. The results demonstrate that both L-methionine and N-acetyl-L-methionine decrease the rate of reaction of cisplatin with base residues in natural, high molecular mass DNA. Thus, the possibility that cisplatin bound to methionine residues serves as a drug reservoir available for platination of DNA in the nucleus of tumor cells appears unlikely. (en)
Title	L-Methionine inhibits reaction of DNA with anticancer cis-diamminedichloroplatinum(II). L-Methionine inhibits reaction of DNA with anticancer cis-diamminedichloroplatinum(II). (en)
skos:prefLabel	L-Methionine inhibits reaction of DNA with anticancer cis-diamminedichloroplatinum(II). L-Methionine inhibits reaction of DNA with anticancer cis-diamminedichloroplatinum(II). (en)
skos:notation	RIV/68081707:_____/02:17023023!RIV/2003/AV0/A17003/N
http://linked.open.../vavai/riv/strany	10994;10999
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(IAA5004101), P(NL6069), Z(AV0Z5004920)
http://linked.open...iv/cisloPeriodika	36
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Brabec, Viktor Vrána, Oldřich
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	651962
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/02:17023023
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	drug cisplatin; adducts; binding (en)
http://linked.open.../riv/klicoveSlovo	adducts binding drug cisplatin
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[3AD945186B4F]
http://linked.open...i/riv/nazevZdroje	Biochemistry
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Mutegenic effects of platinum compounds.Relations to the development of new anticancer drugs Structure, recognition and biochemistry of DNA modified by antitumor platinum drugs
http://linked.open...UplatneniVysledku	2002
http://linked.open...v/svazekPeriodika	41
http://linked.open...iv/tvurceVysledku	Brabec, Viktor Vrána, Oldřich
http://linked.open...n/vavai/riv/zamer	Biophysical properties of living systems and their changes under the influence of environmental factors
issn	0006-2960
number of pages	6 (xsd:int)

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