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rdf:type
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Description
| - The stabilization of DNA can be affected by all the types of chemical modifications of DNA (interstrand cross-links, intrastrand cross-links or monofunctional adducts) which give rise to a strong enough local stabilization of the double helix. Our calculation demonstrates that an increase in stability by 25 to 30 kcal in the free energy of a single base pair of the double helix is sufficient for conserving the helicity of this base pair and preventing strand separation after melting of ordinary base pairs. For the situation where there is more then one stabilized site in a DNA duplex, a lower stabilization per site is sufficient (18 - 20 kcal). A substantial increase in DNA stability was found in various experimental studies for some metal-based antitumor compounds. Stretches of GC pairs more than 25 bp in length inserted into poly(AT) DNA also exhibit properties of stabilizing interstrand cross-links.
- The stabilization of DNA can be affected by all the types of chemical modifications of DNA (interstrand cross-links, intrastrand cross-links or monofunctional adducts) which give rise to a strong enough local stabilization of the double helix. Our calculation demonstrates that an increase in stability by 25 to 30 kcal in the free energy of a single base pair of the double helix is sufficient for conserving the helicity of this base pair and preventing strand separation after melting of ordinary base pairs. For the situation where there is more then one stabilized site in a DNA duplex, a lower stabilization per site is sufficient (18 - 20 kcal). A substantial increase in DNA stability was found in various experimental studies for some metal-based antitumor compounds. Stretches of GC pairs more than 25 bp in length inserted into poly(AT) DNA also exhibit properties of stabilizing interstrand cross-links. (en)
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Title
| - Melting of cross-linked DNA V. Cross-linking effect caused by local stabilization of the double helix.
- Melting of cross-linked DNA V. Cross-linking effect caused by local stabilization of the double helix. (en)
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skos:prefLabel
| - Melting of cross-linked DNA V. Cross-linking effect caused by local stabilization of the double helix.
- Melting of cross-linked DNA V. Cross-linking effect caused by local stabilization of the double helix. (en)
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skos:notation
| - RIV/68081707:_____/03:17033293!RIV/2004/AV0/A17004/N
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(GA305/02/1552), P(IAA5004101), Z(AV0Z5004920)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/68081707:_____/03:17033293
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - cross-links; double helix; DNA (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Journal of Biomolecular Structure and Dynamics
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...ocetUcastnikuAkce
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http://linked.open...nichUcastnikuAkce
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Brabec, Viktor
- Fridman, A. S.
- Haroutiunian, S. G.
- Lando, D. Y.
- Wartell, R. M.
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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