About: Formation of platinated GG cross-links on DNA by photoactivation of a Pt(IV) azide complex.

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About: Formation of platinated GG cross-links on DNA by photoactivation of a Pt(IV) azide complex. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We are exploring the design of platinum complexes with low toxicity that could be photoactivated selectively at the target site. We show here that the Pt(IV) azide complex cis,trans-[Pt(en)(N3)2(OH)2] is unreactive towards DNA until irradiated with visible light. Transcription mapping studies of DNA treated with cis,trans-[Pt(en)(N3)2(OH)2] and irradiated with visible light showed that the platination sites were similar to those observed for cisplatin, and were mainly in GG sequences. HPLC analysis of enzymatic digests of an irradiated sample of DNA duplex treated with the same complex also revealed preferential formation of GG cross-links. Since such DNA lesions are thought to be responsible for the induction of apoptosis in cancer cells by platinum drugs, the use of unreactive photoactivatable platinum pro-drugs may become an effective strategy for the design of a new generation of platinum anticancer complexes. We are exploring the design of platinum complexes with low toxicity that could be photoactivated selectively at the target site. We show here that the Pt(IV) azide complex cis,trans-[Pt(en)(N3)2(OH)2] is unreactive towards DNA until irradiated with visible light. Transcription mapping studies of DNA treated with cis,trans-[Pt(en)(N3)2(OH)2] and irradiated with visible light showed that the platination sites were similar to those observed for cisplatin, and were mainly in GG sequences. HPLC analysis of enzymatic digests of an irradiated sample of DNA duplex treated with the same complex also revealed preferential formation of GG cross-links. Since such DNA lesions are thought to be responsible for the induction of apoptosis in cancer cells by platinum drugs, the use of unreactive photoactivatable platinum pro-drugs may become an effective strategy for the design of a new generation of platinum anticancer complexes. (en)
Title	Formation of platinated GG cross-links on DNA by photoactivation of a Pt(IV) azide complex. Formation of platinated GG cross-links on DNA by photoactivation of a Pt(IV) azide complex. (en)
skos:prefLabel	Formation of platinated GG cross-links on DNA by photoactivation of a Pt(IV) azide complex. Formation of platinated GG cross-links on DNA by photoactivation of a Pt(IV) azide complex. (en)
skos:notation	RIV/68081707:_____/03:17033047!RIV/2004/AV0/A17004/N
http://linked.open.../vavai/riv/strany	741;745
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(IAA5004101), P(KJB5004301), Z(AV0Z5004920)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Brabec, Viktor Kašpárková, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	607587
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/03:17033047
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cross-links; DNA; guanine (en)
http://linked.open.../riv/klicoveSlovo	guanine DNA cross-links
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[2974D4B73AC7]
http://linked.open...i/riv/nazevZdroje	Journal of Biological Inorganic Chemistry
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Structure, recognition and biochemistry of DNA modified by antitumor platinum drugs Molecular mechanisms underlying anticancer effects of a new drug BBR3464
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	8
http://linked.open...iv/tvurceVysledku	Brabec, Viktor Kašpárková, Jana Sadler, P. J. Mackay, F. S.
http://linked.open...n/vavai/riv/zamer	Biophysical properties of living systems and their changes under the influence of environmental factors
issn	0949-8257
number of pages	5 (xsd:int)

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